Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan

26 páginas, 10 figuras, 1 tabla.-- El documento en word es la versión post-print del artículo.

Detalles Bibliográficos
Autores: Álvarez, Yolanda, Municio, Cristina, Hugo, Etzel, Zhu, Jimmy, Alonso, Sara, Hu, Xiaoyu, Fernández, Nieves, Sánchez Crespo, Mariano
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/49362
Acceso en línea:http://hdl.handle.net/10261/49362
Access Level:acceso abierto
Palabra clave:Dendritic cells
Histone deacetylases
Lipopolysaccharide (LPS)
NF-kappa B
Notch pathway
Innate immunity
Beta-glucans
Fungal infection
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spelling Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosanÁlvarez, YolandaMunicio, CristinaHugo, EtzelZhu, JimmyAlonso, SaraHu, XiaoyuFernández, NievesSánchez Crespo, MarianoDendritic cellsHistone deacetylasesLipopolysaccharide (LPS)NF-kappa BNotch pathwayInnate immunityBeta-glucansFungal infection26 páginas, 10 figuras, 1 tabla.-- El documento en word es la versión post-print del artículo.The fungal analog zymosan induces IL-23 and low amounts of IL-12 p70. This study addresses the molecular mechanisms underlying this cytokine pattern in human monocyte-derived dendritic cells. The transcriptional regulation of il23a, one of the chains of IL-23, depended on the activation of c-Rel and histone H3 phosphorylation, as judged from the association of c-Rel with the il23a promoter and the correlation between IL-23 production and S10-histone H3 phosphorylation. Consistent with its reduced ability to produce IL-12 p70, zymosan induced a transient occupancy of the il12a promoter by c-Rel, blocked the production of IL-12 p70 and the transcription of il12a induced by other stimuli, and triggered the expression and nuclear translocation of the transcriptional repressors of the Notch family hairy and enhancer of split (Hes)-1, Hes5, hairy/enhancer-of-split related with YRPW motif protein (Hey)-1, and TLE (transducin-like enhancer of split). Zymosan also induced the interaction of Hes1 and TLE with histone H3 phosphorylated on S10 and deacetylated on K14. Inhibition of class III histone deacetylases increased the production of IL-12 p70 and partially blunted the inhibitory effect of zymosan on the production of IL-12 p70 elicited by LPS and IFN-γ. These results indicate that the selective induction of IL-23 byβ-glucans is explained by the activation of c-Rel associated with S10-histone H3 phosphorylation in the il23a promoter mediated by mitogen- and stress-activated kinase (MSK) and/or protein kinase A, and inhibition of il12a transcription by a mechanism involving activation of several corepressors with ability to bind TLE and to promote histone deacetylation.Peer reviewedAmerican Society for Biochemistry and Molecular Biology201220122011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/49362reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1074/jbc.M111.222158info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/493622026-05-22T06:33:51Z
dc.title.none.fl_str_mv Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
title Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
spellingShingle Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
Álvarez, Yolanda
Dendritic cells
Histone deacetylases
Lipopolysaccharide (LPS)
NF-kappa B
Notch pathway
Innate immunity
Beta-glucans
Fungal infection
title_short Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
title_full Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
title_fullStr Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
title_full_unstemmed Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
title_sort Notch and transducin-like enhancer of split(TLE)-dependent histone deacetylation explain IL-12 p70 inhibition by zymosan
dc.creator.none.fl_str_mv Álvarez, Yolanda
Municio, Cristina
Hugo, Etzel
Zhu, Jimmy
Alonso, Sara
Hu, Xiaoyu
Fernández, Nieves
Sánchez Crespo, Mariano
author Álvarez, Yolanda
author_facet Álvarez, Yolanda
Municio, Cristina
Hugo, Etzel
Zhu, Jimmy
Alonso, Sara
Hu, Xiaoyu
Fernández, Nieves
Sánchez Crespo, Mariano
author_role author
author2 Municio, Cristina
Hugo, Etzel
Zhu, Jimmy
Alonso, Sara
Hu, Xiaoyu
Fernández, Nieves
Sánchez Crespo, Mariano
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dendritic cells
Histone deacetylases
Lipopolysaccharide (LPS)
NF-kappa B
Notch pathway
Innate immunity
Beta-glucans
Fungal infection
topic Dendritic cells
Histone deacetylases
Lipopolysaccharide (LPS)
NF-kappa B
Notch pathway
Innate immunity
Beta-glucans
Fungal infection
description 26 páginas, 10 figuras, 1 tabla.-- El documento en word es la versión post-print del artículo.
publishDate 2011
dc.date.none.fl_str_mv 2011
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/49362
url http://hdl.handle.net/10261/49362
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1074/jbc.M111.222158
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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