Promoter hypermethylation of the AE2/SLC4A2 gene in PBC

Primary biliary cholangitis (PBC) is a chronic immuneassociated cholestatic liver disease with unclear complex/multifactorial etiopathogenesis affecting mostly middle-aged women. Patients with PBC exhibit reduced expression of the AE2/SLC4A2 gene. Herein, we found that AE2 promoter regions are hyper...

Descripción completa

Detalles Bibliográficos
Autores: Arenas, F. (Fabián)|||/items/6c147b5a-6bfd-4816-b678-37c5219363aa, Hervias, I. (Isabel)|||/items/a2bc8f76-2803-4476-bcbc-cb40fc347ac4, Saez, E. (Elena)|||/items/ee4404ad-c8a8-4a6f-9b3b-3c9cb3a26e41, Melero, S. (Saida)|||/items/188fdaef-be27-4057-ae8e-8b5610a16d8c, Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71, Parés, A. (Albert)|||/items/11388103-c4e4-468f-b2fe-96ed7f0e150c, Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/62283
Acceso en línea:https://hdl.handle.net/10171/62283
Access Level:acceso abierto
Palabra clave:AE2 chloride
Bicarbonate exchanger
Cholestasis
DNA methylation
Epigenetic repression
Primary biliary cholangitis
Cirrhosis
id ES_bde28aa2a7554f1b102d308c8a4cfcfc
oai_identifier_str oai:dadun.unav.edu:10171/62283
network_acronym_str ES
network_name_str España
repository_id_str
spelling Promoter hypermethylation of the AE2/SLC4A2 gene in PBCArenas, F. (Fabián)|||/items/6c147b5a-6bfd-4816-b678-37c5219363aaHervias, I. (Isabel)|||/items/a2bc8f76-2803-4476-bcbc-cb40fc347ac4Saez, E. (Elena)|||/items/ee4404ad-c8a8-4a6f-9b3b-3c9cb3a26e41Melero, S. (Saida)|||/items/188fdaef-be27-4057-ae8e-8b5610a16d8cPrieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71Parés, A. (Albert)|||/items/11388103-c4e4-468f-b2fe-96ed7f0e150cMedina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cfAE2 chlorideBicarbonate exchangerCholestasisDNA methylationEpigenetic repressionPrimary biliary cholangitisCirrhosisPrimary biliary cholangitis (PBC) is a chronic immuneassociated cholestatic liver disease with unclear complex/multifactorial etiopathogenesis affecting mostly middle-aged women. Patients with PBC exhibit reduced expression of the AE2/SLC4A2 gene. Herein, we found that AE2 promoter regions are hypermethylated in the liver and peripheral blood mononuclear cells of patients with PBC. This increased methylation is associated with downregulated AE2-gene expression, which might contribute to the pathogenesis of PBC. Therefore, novel epigenetic targets may improve treatment in patients with PBC who respond poorly to current pharmacological therapies.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20212021-10-2720192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/62283reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/622832026-06-21T12:47:57Z
dc.title.none.fl_str_mv Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
title Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
spellingShingle Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
Arenas, F. (Fabián)|||/items/6c147b5a-6bfd-4816-b678-37c5219363aa
AE2 chloride
Bicarbonate exchanger
Cholestasis
DNA methylation
Epigenetic repression
Primary biliary cholangitis
Cirrhosis
title_short Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
title_full Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
title_fullStr Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
title_full_unstemmed Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
title_sort Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
dc.creator.none.fl_str_mv Arenas, F. (Fabián)|||/items/6c147b5a-6bfd-4816-b678-37c5219363aa
Hervias, I. (Isabel)|||/items/a2bc8f76-2803-4476-bcbc-cb40fc347ac4
Saez, E. (Elena)|||/items/ee4404ad-c8a8-4a6f-9b3b-3c9cb3a26e41
Melero, S. (Saida)|||/items/188fdaef-be27-4057-ae8e-8b5610a16d8c
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Parés, A. (Albert)|||/items/11388103-c4e4-468f-b2fe-96ed7f0e150c
Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
author Arenas, F. (Fabián)|||/items/6c147b5a-6bfd-4816-b678-37c5219363aa
author_facet Arenas, F. (Fabián)|||/items/6c147b5a-6bfd-4816-b678-37c5219363aa
Hervias, I. (Isabel)|||/items/a2bc8f76-2803-4476-bcbc-cb40fc347ac4
Saez, E. (Elena)|||/items/ee4404ad-c8a8-4a6f-9b3b-3c9cb3a26e41
Melero, S. (Saida)|||/items/188fdaef-be27-4057-ae8e-8b5610a16d8c
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Parés, A. (Albert)|||/items/11388103-c4e4-468f-b2fe-96ed7f0e150c
Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
author_role author
author2 Hervias, I. (Isabel)|||/items/a2bc8f76-2803-4476-bcbc-cb40fc347ac4
Saez, E. (Elena)|||/items/ee4404ad-c8a8-4a6f-9b3b-3c9cb3a26e41
Melero, S. (Saida)|||/items/188fdaef-be27-4057-ae8e-8b5610a16d8c
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Parés, A. (Albert)|||/items/11388103-c4e4-468f-b2fe-96ed7f0e150c
Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv AE2 chloride
Bicarbonate exchanger
Cholestasis
DNA methylation
Epigenetic repression
Primary biliary cholangitis
Cirrhosis
topic AE2 chloride
Bicarbonate exchanger
Cholestasis
DNA methylation
Epigenetic repression
Primary biliary cholangitis
Cirrhosis
description Primary biliary cholangitis (PBC) is a chronic immuneassociated cholestatic liver disease with unclear complex/multifactorial etiopathogenesis affecting mostly middle-aged women. Patients with PBC exhibit reduced expression of the AE2/SLC4A2 gene. Herein, we found that AE2 promoter regions are hypermethylated in the liver and peripheral blood mononuclear cells of patients with PBC. This increased methylation is associated with downregulated AE2-gene expression, which might contribute to the pathogenesis of PBC. Therefore, novel epigenetic targets may improve treatment in patients with PBC who respond poorly to current pharmacological therapies.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
2021
2021-10-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/62283
url https://hdl.handle.net/10171/62283
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418239206883328
score 15,300719

Similares en LA Referencia