Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study

BackgroundPrevious studies investigating the relationship of influenza with acute myocardial infarction (AMI) have not distinguished between AMI types 1 and 2. Influenza and cold temperature can explain the increased incidence of AMI during winter but, because they are closely related in temperate r...

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Autores: García‐Lledó, Alberto, Rodríguez-Martín, Sara, Tobías, Aurelio, García‐de‐Santiago, Elvira, Ordobás‐Gavín, María, Ansede-Cascudo, Juan Carlos, Alonso‐Martín, Joaquin, de Abajo, Francisco J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/242723
Acceso en línea:http://hdl.handle.net/10261/242723
Access Level:acceso abierto
Palabra clave:Cold
Temperatures
Vaccine
Myocardial infarction
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spelling Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series StudyGarcía‐Lledó, AlbertoRodríguez-Martín, SaraTobías, AurelioGarcía‐de‐Santiago, ElviraOrdobás‐Gavín, MaríaAnsede-Cascudo, Juan CarlosAlonso‐Martín, Joaquinde Abajo, Francisco J.ColdTemperaturesVaccineMyocardial infarctionBackgroundPrevious studies investigating the relationship of influenza with acute myocardial infarction (AMI) have not distinguished between AMI types 1 and 2. Influenza and cold temperature can explain the increased incidence of AMI during winter but, because they are closely related in temperate regions, their relative contribution is unknown. Methods and ResultsThe temporal relationship between incidence rates of AMI with demonstrated culprit plaque (type 1 AMI) from the regional primary angioplasty network and influenza, adjusted for ambient temperature, was studied in Madrid region (Spain) during 5 influenza seasons (from June 2013 to June 2018). A time‐series analysis with quasi‐Poisson regression models and distributed lag‐nonlinear models was used. The incidence rate of type 1 AMI according to influenza vaccination status was also explored. A total of 8240 cases of confirmed type 1 AMI were recorded. The overall risk ratio (RR) of type 1 AMI during epidemic periods, adjusted for year, month, and temperature, was 1.23 (95% CI, 1.03–1.47). An increase of weekly influenza rate of 50 cases per 100 000 inhabitants resulted in an RR for type 1 AMI of 1.16 (95% CI, 1.09–1.23) during the same week, disappearing 1 week after. When adjusted for influenza, a decrease of 1ºC in the minimum temperature resulted in an increase of 2.5% type 1 AMI. Influenza vaccination was associated with a decreased risk of type 1 AMI in subjects aged 60 to 64 years (RR, 0.58; 95% CI, 0.47–0.71) and ≥65 years (RR, 0.53; 95% CI, 0.49–0.57). ConclusionsInfluenza and cold temperature were both independently associated with an increased risk of type 1 AMI, whereas vaccination was associated with a reduced risk among older patients.This work has been partially funded by unrestricted research grants from the Fundación para la Investigación Biomédica, University Hospital “Príncipe de Asturias” (Servicio Madrileño de Salud, Madrid, Spain) (to Drs García‐Lledó and de Abajo) and funding from Sanofi‐Pasteur S.A., a manufacturer of influenza vaccines (to Dr de Abajo). The funders had no role in the study design, data collection, data analysis, data interpretation, or writing the report. Dr Tobías received support from the Japanese Society for the Promotion of Science in its invitation‐to‐research fellowship program in Japan (S18149).Peer reviewedAmerican Heart AssociationTobías, Aurelio [0000-0001-6428-6755]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/242723reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1161/JAHA.120.019608Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2427232026-05-22T06:33:51Z
dc.title.none.fl_str_mv Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
title Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
spellingShingle Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
García‐Lledó, Alberto
Cold
Temperatures
Vaccine
Myocardial infarction
title_short Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
title_full Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
title_fullStr Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
title_full_unstemmed Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
title_sort Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time‐Series Study
dc.creator.none.fl_str_mv García‐Lledó, Alberto
Rodríguez-Martín, Sara
Tobías, Aurelio
García‐de‐Santiago, Elvira
Ordobás‐Gavín, María
Ansede-Cascudo, Juan Carlos
Alonso‐Martín, Joaquin
de Abajo, Francisco J.
author García‐Lledó, Alberto
author_facet García‐Lledó, Alberto
Rodríguez-Martín, Sara
Tobías, Aurelio
García‐de‐Santiago, Elvira
Ordobás‐Gavín, María
Ansede-Cascudo, Juan Carlos
Alonso‐Martín, Joaquin
de Abajo, Francisco J.
author_role author
author2 Rodríguez-Martín, Sara
Tobías, Aurelio
García‐de‐Santiago, Elvira
Ordobás‐Gavín, María
Ansede-Cascudo, Juan Carlos
Alonso‐Martín, Joaquin
de Abajo, Francisco J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Tobías, Aurelio [0000-0001-6428-6755]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cold
Temperatures
Vaccine
Myocardial infarction
topic Cold
Temperatures
Vaccine
Myocardial infarction
description BackgroundPrevious studies investigating the relationship of influenza with acute myocardial infarction (AMI) have not distinguished between AMI types 1 and 2. Influenza and cold temperature can explain the increased incidence of AMI during winter but, because they are closely related in temperate regions, their relative contribution is unknown. Methods and ResultsThe temporal relationship between incidence rates of AMI with demonstrated culprit plaque (type 1 AMI) from the regional primary angioplasty network and influenza, adjusted for ambient temperature, was studied in Madrid region (Spain) during 5 influenza seasons (from June 2013 to June 2018). A time‐series analysis with quasi‐Poisson regression models and distributed lag‐nonlinear models was used. The incidence rate of type 1 AMI according to influenza vaccination status was also explored. A total of 8240 cases of confirmed type 1 AMI were recorded. The overall risk ratio (RR) of type 1 AMI during epidemic periods, adjusted for year, month, and temperature, was 1.23 (95% CI, 1.03–1.47). An increase of weekly influenza rate of 50 cases per 100 000 inhabitants resulted in an RR for type 1 AMI of 1.16 (95% CI, 1.09–1.23) during the same week, disappearing 1 week after. When adjusted for influenza, a decrease of 1ºC in the minimum temperature resulted in an increase of 2.5% type 1 AMI. Influenza vaccination was associated with a decreased risk of type 1 AMI in subjects aged 60 to 64 years (RR, 0.58; 95% CI, 0.47–0.71) and ≥65 years (RR, 0.53; 95% CI, 0.49–0.57). ConclusionsInfluenza and cold temperature were both independently associated with an increased risk of type 1 AMI, whereas vaccination was associated with a reduced risk among older patients.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/242723
url http://hdl.handle.net/10261/242723
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1161/JAHA.120.019608
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Heart Association
publisher.none.fl_str_mv American Heart Association
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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