Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study

The amount of information that can be retained in working memory (WM) is limited. Limitations of WM capacity have been the subject of intense research, especially in trying to specify algorithmic models for WM. Comparatively, neural circuit perspectives have barely been used to test WM limitations i...

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Detalles Bibliográficos
Autores: Almeida, Rita, Barbosa, João Moura, Compte Braquets, Albert
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/208048
Acceso en línea:https://hdl.handle.net/2445/208048
Access Level:acceso abierto
Palabra clave:Neurones
Percepció de l'espai
Neurons
Space Perception
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spelling Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral studyAlmeida, RitaBarbosa, João MouraCompte Braquets, AlbertNeuronesPercepció de l'espaiNeuronsSpace PerceptionThe amount of information that can be retained in working memory (WM) is limited. Limitations of WM capacity have been the subject of intense research, especially in trying to specify algorithmic models for WM. Comparatively, neural circuit perspectives have barely been used to test WM limitations in behavioral experiments. Here we used a neuronal microcircuit model for visuo-spatial WM (vsWM) to investigate memory of several items. The model assumes that there is a topographic organization of the circuit responsible for spatial memory retention. This assumption leads to specific predictions, which we tested in behavioral experiments. According to the model, nearby locations should be recalled with a bias, as if the two memory traces showed attraction or repulsion during the delay period depending on distance. Another prediction is that the previously reported loss of memory precision for an increasing number of memory items (memory load) should vanish when the distances between items are controlled for. Both predictions were confirmed experimentally. Taken together, our findings provide support for a topographic neural circuit organization of vsWM, they suggest that interference between similar memories underlies some WM limitations, and they put forward a circuit-based explanation that reconciles previous conflicting results on the dependence of WM precision with load. Copyright © 2015 the American Physiological Society.American Physiological Society2024202420152024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion45 p.application/pdfhttps://hdl.handle.net/2445/208048Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1152/jn.00362.2015Journal Of Neurophysiology, 2015, vol. 114, num. 3, p. 1806-1818https://doi.org/10.1152/jn.00362.2015(c) American Physiological Society, 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2080482026-05-29T05:05:01Z
dc.title.none.fl_str_mv Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
title Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
spellingShingle Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
Almeida, Rita
Neurones
Percepció de l'espai
Neurons
Space Perception
title_short Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
title_full Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
title_fullStr Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
title_full_unstemmed Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
title_sort Neural circuit basis of visuo-spatial working memory precision: A computational and behavioral study
dc.creator.none.fl_str_mv Almeida, Rita
Barbosa, João Moura
Compte Braquets, Albert
author Almeida, Rita
author_facet Almeida, Rita
Barbosa, João Moura
Compte Braquets, Albert
author_role author
author2 Barbosa, João Moura
Compte Braquets, Albert
author2_role author
author
dc.subject.none.fl_str_mv Neurones
Percepció de l'espai
Neurons
Space Perception
topic Neurones
Percepció de l'espai
Neurons
Space Perception
description The amount of information that can be retained in working memory (WM) is limited. Limitations of WM capacity have been the subject of intense research, especially in trying to specify algorithmic models for WM. Comparatively, neural circuit perspectives have barely been used to test WM limitations in behavioral experiments. Here we used a neuronal microcircuit model for visuo-spatial WM (vsWM) to investigate memory of several items. The model assumes that there is a topographic organization of the circuit responsible for spatial memory retention. This assumption leads to specific predictions, which we tested in behavioral experiments. According to the model, nearby locations should be recalled with a bias, as if the two memory traces showed attraction or repulsion during the delay period depending on distance. Another prediction is that the previously reported loss of memory precision for an increasing number of memory items (memory load) should vanish when the distances between items are controlled for. Both predictions were confirmed experimentally. Taken together, our findings provide support for a topographic neural circuit organization of vsWM, they suggest that interference between similar memories underlies some WM limitations, and they put forward a circuit-based explanation that reconciles previous conflicting results on the dependence of WM precision with load. Copyright © 2015 the American Physiological Society.
publishDate 2015
dc.date.none.fl_str_mv 2015
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208048
url https://hdl.handle.net/2445/208048
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1152/jn.00362.2015
Journal Of Neurophysiology, 2015, vol. 114, num. 3, p. 1806-1818
https://doi.org/10.1152/jn.00362.2015
dc.rights.none.fl_str_mv (c) American Physiological Society, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Physiological Society, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 45 p.
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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