Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease
The amyloid-β protein precursor/presenilin 1 (AβPP/PS1) mouse model of Alzheimer's disease (AD) has provided robust neuropathological hallmarks of familial AD-like pattern. AD is a neurodegenerative process that causes severe cognitive impairment; it is characterized by the accumulation of amyl...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/67989 |
| Acesso em linha: | https://hdl.handle.net/2445/67989 |
| Access Level: | acceso abierto |
| Palavra-chave: | Malaltia d'Alzheimer Mitocondris Malalties neurodegeneratives Polifenols Alzheimer's disease Mitochondria Neurodegenerative Diseases Polyphenols |
| id |
ES_bdb02da2f2b7423fd190aace362347ec |
|---|---|
| oai_identifier_str |
oai:recercat.cat:2445/67989 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease Porquet Costa, DavidGriñán Ferré, ChristianFerrer, Isidro (Ferrer Abizanda)Camins Espuny, AntoniSanfeliu i Pujol, CoralValle i Macià, Jaume delPallàs i Llibería, Mercè, 1964-Malaltia d'AlzheimerMitocondrisMalalties neurodegenerativesPolifenolsAlzheimer's diseaseMitochondriaNeurodegenerative DiseasesPolyphenolsThe amyloid-β protein precursor/presenilin 1 (AβPP/PS1) mouse model of Alzheimer's disease (AD) has provided robust neuropathological hallmarks of familial AD-like pattern. AD is a neurodegenerative process that causes severe cognitive impairment; it is characterized by the accumulation of amyloid-β (Aβ) and hyperphosphorylated tau forms and by oxidative and inflammatory processes in brain. Currently, efforts are made to understand biochemical pathways because there is no effective therapy for AD. Resveratrol is a polyphenol that induces expression and activation of several neuroprotective pathways involving Sirtuin1 and AMPK. The objective of this work was to assess the effect of oral resveratrol administration on AβPP/PS1 mice. Long-term resveratrol treatment significantly prevented memory loss as measured by the object recognition test. Moreover, resveratrol reduced the amyloid burden and increased mitochondrial complex IV protein levels in mouse brain. These protective effects of resveratrol were mainly mediated by increased activation of Sirtuin 1 and AMPK pathways in mice. However, an increase has been observed in IL1β and TNF gene expression, indicating that resveratrol promoted changes in inflammatory processes, although no changes were detected in other key actors of the oxidative stress pathway. Taken together, our findings suggest that resveratrol is able to reduce the harmful process that occurs in AβPP/PS1 mouse hippocampus, preventing memory loss.IOS Press2015201520142015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/67989Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.3233/JAD-140444Journal of Alzheimer's Disease, 2014, vol. 42, num. 4, p. 1209-1220http://dx.doi.org/10.3233/JAD-140444(c) Porquet Costa et al., 2014info:eu-repo/semantics/openAccessoai:recercat.cat:2445/679892026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease |
| title |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease |
| spellingShingle |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease Porquet Costa, David Malaltia d'Alzheimer Mitocondris Malalties neurodegeneratives Polifenols Alzheimer's disease Mitochondria Neurodegenerative Diseases Polyphenols |
| title_short |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease |
| title_full |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease |
| title_fullStr |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease |
| title_full_unstemmed |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease |
| title_sort |
Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease |
| dc.creator.none.fl_str_mv |
Porquet Costa, David Griñán Ferré, Christian Ferrer, Isidro (Ferrer Abizanda) Camins Espuny, Antoni Sanfeliu i Pujol, Coral Valle i Macià, Jaume del Pallàs i Llibería, Mercè, 1964- |
| author |
Porquet Costa, David |
| author_facet |
Porquet Costa, David Griñán Ferré, Christian Ferrer, Isidro (Ferrer Abizanda) Camins Espuny, Antoni Sanfeliu i Pujol, Coral Valle i Macià, Jaume del Pallàs i Llibería, Mercè, 1964- |
| author_role |
author |
| author2 |
Griñán Ferré, Christian Ferrer, Isidro (Ferrer Abizanda) Camins Espuny, Antoni Sanfeliu i Pujol, Coral Valle i Macià, Jaume del Pallàs i Llibería, Mercè, 1964- |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Malaltia d'Alzheimer Mitocondris Malalties neurodegeneratives Polifenols Alzheimer's disease Mitochondria Neurodegenerative Diseases Polyphenols |
| topic |
Malaltia d'Alzheimer Mitocondris Malalties neurodegeneratives Polifenols Alzheimer's disease Mitochondria Neurodegenerative Diseases Polyphenols |
| description |
The amyloid-β protein precursor/presenilin 1 (AβPP/PS1) mouse model of Alzheimer's disease (AD) has provided robust neuropathological hallmarks of familial AD-like pattern. AD is a neurodegenerative process that causes severe cognitive impairment; it is characterized by the accumulation of amyloid-β (Aβ) and hyperphosphorylated tau forms and by oxidative and inflammatory processes in brain. Currently, efforts are made to understand biochemical pathways because there is no effective therapy for AD. Resveratrol is a polyphenol that induces expression and activation of several neuroprotective pathways involving Sirtuin1 and AMPK. The objective of this work was to assess the effect of oral resveratrol administration on AβPP/PS1 mice. Long-term resveratrol treatment significantly prevented memory loss as measured by the object recognition test. Moreover, resveratrol reduced the amyloid burden and increased mitochondrial complex IV protein levels in mouse brain. These protective effects of resveratrol were mainly mediated by increased activation of Sirtuin 1 and AMPK pathways in mice. However, an increase has been observed in IL1β and TNF gene expression, indicating that resveratrol promoted changes in inflammatory processes, although no changes were detected in other key actors of the oxidative stress pathway. Taken together, our findings suggest that resveratrol is able to reduce the harmful process that occurs in AβPP/PS1 mouse hippocampus, preventing memory loss. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 2015 2015 2015 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/67989 |
| url |
https://hdl.handle.net/2445/67989 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/10.3233/JAD-140444 Journal of Alzheimer's Disease, 2014, vol. 42, num. 4, p. 1209-1220 http://dx.doi.org/10.3233/JAD-140444 |
| dc.rights.none.fl_str_mv |
(c) Porquet Costa et al., 2014 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Porquet Costa et al., 2014 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
12 p. application/pdf |
| dc.publisher.none.fl_str_mv |
IOS Press |
| publisher.none.fl_str_mv |
IOS Press |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Patologia i Terapèutica Experimental) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869418221482803200 |
| score |
15,811543 |