Ambient temperature drying of therapeutic protein solution with use of microwave
[EN] High quality drying of therapeutic protein-solution is important in medical and pharmaceutical processing. Freeze-drying is mostly used, but it takes a long drying-time and causes damages of protein structures. In order to improve the drying quality, we propose a microwave vacuum drying perform...
| Autores: | , , , |
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| Tipo de recurso: | capítulo de libro |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/117936 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/117936 |
| Access Level: | acceso abierto |
| Palabra clave: | Drying Dehydration Dewatering Emerging technologies Products quality Process control Environmental Evaporation Sublimation Diffusion Energy Intensification Microwave vacuum drying Freeze-drying Therapeutic protein Egg white Lysozyme |
| Sumario: | [EN] High quality drying of therapeutic protein-solution is important in medical and pharmaceutical processing. Freeze-drying is mostly used, but it takes a long drying-time and causes damages of protein structures. In order to improve the drying quality, we propose a microwave vacuum drying performed at ambient temperatures under low-pressure conditions. We are focusing on the Parma-Zyme method for the evaporative drying of protein solutions such as egg white or lysozyme with vitrification. Circular dichroism (CD) spectroscopy is used to detect protein conformation changes due to the drying, and it is found that the ambient temperature drying can preserve the protein conformation. |
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