Modulation of calcium entry by mitochondria

The role of mitochondria in intracellular Ca(2+) signaling relies mainly in its capacity to take up Ca(2+) from the cytosol and thus modulate the cytosolic [Ca(2+)]. Because of the low Ca(2+)-affinity of the mitochondrial Ca(2+)-uptake system, this organelle appears specially adapted to take up Ca(2...

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Detalles Bibliográficos
Autores: Fonteriz, Rosalba I., Matesanz-Isabel, Jessica, Arias-del-Val, Jessica, Alvarez-Illera, Pilar, Montero, Mayte, Álvarez, Javier
Tipo de recurso: otro
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/158077
Acceso en línea:http://hdl.handle.net/10261/158077
Access Level:acceso abierto
Palabra clave:Mitochondria
Store-operated Ca2+ entry
SOCE
Endoplasmic reticulum
STIM
MCU
Ca2+ uniporter Ca2+ microdomain
CRAC channels
Orai
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oai_identifier_str oai:digital.csic.es:10261/158077
network_acronym_str ES
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repository_id_str
spelling Modulation of calcium entry by mitochondriaFonteriz, Rosalba I.Matesanz-Isabel, JessicaArias-del-Val, JessicaAlvarez-Illera, PilarMontero, MayteÁlvarez, JavierMitochondriaStore-operated Ca2+ entrySOCEEndoplasmic reticulumSTIMMCUCa2+ uniporter Ca2+ microdomainCRAC channelsOraiThe role of mitochondria in intracellular Ca(2+) signaling relies mainly in its capacity to take up Ca(2+) from the cytosol and thus modulate the cytosolic [Ca(2+)]. Because of the low Ca(2+)-affinity of the mitochondrial Ca(2+)-uptake system, this organelle appears specially adapted to take up Ca(2+) from local high-Ca(2+) microdomains and not from the bulk cytosol. Mitochondria would then act as local Ca(2+) buffers in cellular regions where high-Ca(2+) microdomains form, that is, mainly close to the cytosolic mouth of Ca(2+) channels, both in the plasma membrane and in the endoplasmic reticulum (ER). One of the first targets proposed already in the 1990s to be regulated in this way by mitochondria were the store-operated Ca(2+) channels (SOCE). Mitochondria, by taking up Ca(2+) from the region around the cytosolic mouth of the SOCE channels, would prevent its slow Ca(2+)-dependent inactivation, thus keeping them active for longer. Since then, evidence for this mechanism has accumulated mainly in immunitary cells, where mitochondria actually move towards the immune synapse during T cell activation. However, in many other cell types the available data indicate that the close apposition between plasma and ER membranes occurring during SOCE activation precludes mitochondria from getting close to the Ca(2+)-entry sites. Alternative pathways for mitochondrial modulation of SOCE, both Ca(2+)-dependent and Ca(2+)-independent, have also been proposed, but further work will be required to elucidate the actual mechanisms at work. Hopefully, the recent knowledge of the molecular nature of the mitochondrial Ca(2+) uniporter will allow soon more precise studies on this matter.This work was supported by a grant from the Spanish Ministerio de Ciencia e Innovación (BFU2011-25763). Jessica Matesanz-Isabel holds a FPI (Formación de Personal Investigador) fellowship from the Spanish Government. Jessica Arias-del-Val holds a fellowship from Junta de Castilla y León.Peer ReviewedSpringer NatureMinisterio de Ciencia e Innovación (España)Junta de Castilla y LeónConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720162017info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Preprintinfo:eu-repo/semantics/submittedVersioninfo:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/158077reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésAdvances in Experimental Medicine and Biology 898https://doi.org/10.1007/978-3-319-26974-0_17Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1580772026-05-22T06:33:51Z
dc.title.none.fl_str_mv Modulation of calcium entry by mitochondria
title Modulation of calcium entry by mitochondria
spellingShingle Modulation of calcium entry by mitochondria
Fonteriz, Rosalba I.
Mitochondria
Store-operated Ca2+ entry
SOCE
Endoplasmic reticulum
STIM
MCU
Ca2+ uniporter Ca2+ microdomain
CRAC channels
Orai
title_short Modulation of calcium entry by mitochondria
title_full Modulation of calcium entry by mitochondria
title_fullStr Modulation of calcium entry by mitochondria
title_full_unstemmed Modulation of calcium entry by mitochondria
title_sort Modulation of calcium entry by mitochondria
dc.creator.none.fl_str_mv Fonteriz, Rosalba I.
Matesanz-Isabel, Jessica
Arias-del-Val, Jessica
Alvarez-Illera, Pilar
Montero, Mayte
Álvarez, Javier
author Fonteriz, Rosalba I.
author_facet Fonteriz, Rosalba I.
Matesanz-Isabel, Jessica
Arias-del-Val, Jessica
Alvarez-Illera, Pilar
Montero, Mayte
Álvarez, Javier
author_role author
author2 Matesanz-Isabel, Jessica
Arias-del-Val, Jessica
Alvarez-Illera, Pilar
Montero, Mayte
Álvarez, Javier
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Junta de Castilla y León
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Mitochondria
Store-operated Ca2+ entry
SOCE
Endoplasmic reticulum
STIM
MCU
Ca2+ uniporter Ca2+ microdomain
CRAC channels
Orai
topic Mitochondria
Store-operated Ca2+ entry
SOCE
Endoplasmic reticulum
STIM
MCU
Ca2+ uniporter Ca2+ microdomain
CRAC channels
Orai
description The role of mitochondria in intracellular Ca(2+) signaling relies mainly in its capacity to take up Ca(2+) from the cytosol and thus modulate the cytosolic [Ca(2+)]. Because of the low Ca(2+)-affinity of the mitochondrial Ca(2+)-uptake system, this organelle appears specially adapted to take up Ca(2+) from local high-Ca(2+) microdomains and not from the bulk cytosol. Mitochondria would then act as local Ca(2+) buffers in cellular regions where high-Ca(2+) microdomains form, that is, mainly close to the cytosolic mouth of Ca(2+) channels, both in the plasma membrane and in the endoplasmic reticulum (ER). One of the first targets proposed already in the 1990s to be regulated in this way by mitochondria were the store-operated Ca(2+) channels (SOCE). Mitochondria, by taking up Ca(2+) from the region around the cytosolic mouth of the SOCE channels, would prevent its slow Ca(2+)-dependent inactivation, thus keeping them active for longer. Since then, evidence for this mechanism has accumulated mainly in immunitary cells, where mitochondria actually move towards the immune synapse during T cell activation. However, in many other cell types the available data indicate that the close apposition between plasma and ER membranes occurring during SOCE activation precludes mitochondria from getting close to the Ca(2+)-entry sites. Alternative pathways for mitochondrial modulation of SOCE, both Ca(2+)-dependent and Ca(2+)-independent, have also been proposed, but further work will be required to elucidate the actual mechanisms at work. Hopefully, the recent knowledge of the molecular nature of the mitochondrial Ca(2+) uniporter will allow soon more precise studies on this matter.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Preprint
info:eu-repo/semantics/submittedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/158077
url http://hdl.handle.net/10261/158077
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Advances in Experimental Medicine and Biology 898
https://doi.org/10.1007/978-3-319-26974-0_17
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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