Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense cytokine storm leading finally to a multi-organ failure and death. Comorbidities such as metabolic syndrome, obesity, type 2 diabetes...

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Detalles Bibliográficos
Autores: Fernández-Ayala, Daniel J. M., Navas, Plácido, López-Lluch, Guillermo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/224591
Acceso en línea:http://hdl.handle.net/10261/224591
Access Level:acceso abierto
Palabra clave:COVID-19
SARS-CoV-2
Mitochondria
Inflammaging
Inflammation
Cytokine storm
Mitochondrial health
Mitochondrial nutrients
Mitochondrial turnover
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spelling Age-related mitochondrial dysfunction as a key factor in COVID-19 diseaseFernández-Ayala, Daniel J. M.Navas, PlácidoLópez-Lluch, GuillermoCOVID-19SARS-CoV-2MitochondriaInflammagingInflammationCytokine stormMitochondrial healthMitochondrial nutrientsMitochondrial turnoverInflammationCytokine stormMitochondrial healthMitochondrial nutrientsMitochondrial turnoverSARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense cytokine storm leading finally to a multi-organ failure and death. Comorbidities such as metabolic syndrome, obesity, type 2 diabetes, lung and cardiovascular diseases, all of them age-associated diseases, increase the severity and lethality of COVID-19. Mitochondrial dysfunction is one of the hallmarks of aging and COVID-19 risk factors. Dysfunctional mitochondria is associated with defective immunological response to viral infections and chronic inflammation. This review discuss how mitochondrial dysfunction is associated with defective immune response in aging and different age-related diseases, and with many of the comorbidities associated with poor prognosis in the progression of COVID-19. We suggest here that chronic inflammation caused by mitochondrial dysfunction is responsible of the explosive release of inflammatory cytokines causing severe pneumonia, multi-organ failure and finally death in COVID-19 patients. Preventive treatments based on therapies improving mitochondrial turnover, dynamics and activity would be essential to protect against COVID-19 severity.Peer reviewedElsevier BVConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/224591reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.exger.2020.111147Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2245912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
title Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
spellingShingle Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
Fernández-Ayala, Daniel J. M.
COVID-19
SARS-CoV-2
Mitochondria
Inflammaging
Inflammation
Cytokine storm
Mitochondrial health
Mitochondrial nutrients
Mitochondrial turnover
Inflammation
Cytokine storm
Mitochondrial health
Mitochondrial nutrients
Mitochondrial turnover
title_short Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
title_full Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
title_fullStr Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
title_full_unstemmed Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
title_sort Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
dc.creator.none.fl_str_mv Fernández-Ayala, Daniel J. M.
Navas, Plácido
López-Lluch, Guillermo
author Fernández-Ayala, Daniel J. M.
author_facet Fernández-Ayala, Daniel J. M.
Navas, Plácido
López-Lluch, Guillermo
author_role author
author2 Navas, Plácido
López-Lluch, Guillermo
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv COVID-19
SARS-CoV-2
Mitochondria
Inflammaging
Inflammation
Cytokine storm
Mitochondrial health
Mitochondrial nutrients
Mitochondrial turnover
Inflammation
Cytokine storm
Mitochondrial health
Mitochondrial nutrients
Mitochondrial turnover
topic COVID-19
SARS-CoV-2
Mitochondria
Inflammaging
Inflammation
Cytokine storm
Mitochondrial health
Mitochondrial nutrients
Mitochondrial turnover
Inflammation
Cytokine storm
Mitochondrial health
Mitochondrial nutrients
Mitochondrial turnover
description SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense cytokine storm leading finally to a multi-organ failure and death. Comorbidities such as metabolic syndrome, obesity, type 2 diabetes, lung and cardiovascular diseases, all of them age-associated diseases, increase the severity and lethality of COVID-19. Mitochondrial dysfunction is one of the hallmarks of aging and COVID-19 risk factors. Dysfunctional mitochondria is associated with defective immunological response to viral infections and chronic inflammation. This review discuss how mitochondrial dysfunction is associated with defective immune response in aging and different age-related diseases, and with many of the comorbidities associated with poor prognosis in the progression of COVID-19. We suggest here that chronic inflammation caused by mitochondrial dysfunction is responsible of the explosive release of inflammatory cytokines causing severe pneumonia, multi-organ failure and finally death in COVID-19 patients. Preventive treatments based on therapies improving mitochondrial turnover, dynamics and activity would be essential to protect against COVID-19 severity.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/224591
url http://hdl.handle.net/10261/224591
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.exger.2020.111147
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418215325564928
score 15,811543

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