Cranial and extracranial giant cell arteritis do not exhibit differences in the IL6 -174 G/C gene polymorphism

Since interleukin-6 (IL-6) is a pivotal proinflammatory cytokine implicated in the pathogenesis of giant cell arteritis (GCA), we aimed to determine the potential association of the functional IL6 -174 G/C polymorphism with GCA as well as if the single base change variation at the promoter region in...

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Detalles Bibliográficos
Autores: Genre, Fernanda, Prieto-Peña, Diana, Pulito-Cueto, Verónica, Gonzalo Ocejo-Vinyals, Javier, Atienza-Mateo, Belén, Ortiz-Sanjuán, Francisco, Romero-Yuste, Susana, Galíndez-Agirregoikoa, Eva, Calvo, Itziar, Ortego-Centeno, Norberto, Álvarez-Rivas, Noelia, Miranda-Filloy, J. A., Llorente, Irene, Blanco, Ricardo, Gualillo, Oreste, Martin, Javier, Castañeda, Santos, López-Mejías, Raquel, Remuzgo-Martínez, Sara, González-Gay, Miguel A., Muñoz Jiménez, Alejandro, Moriano, Clara
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/350278
Acceso en línea:http://hdl.handle.net/10261/350278
Access Level:acceso abierto
Descripción
Sumario:Since interleukin-6 (IL-6) is a pivotal proinflammatory cytokine implicated in the pathogenesis of giant cell arteritis (GCA), we aimed to determine the potential association of the functional IL6 -174 G/C polymorphism with GCA as well as if the single base change variation at the promoter region in the human IL-6 gene may account for differences in the clinical spectrum of GCA between cranial and extracranial large vessel vasculitis (LVV)-GCA.