The role of alternative splicing in cancer

The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types. Some of these alterations have bee...

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Detalles Bibliográficos
Autores: Singh, Babita, 1986-, Eyras Jiménez, Eduardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/32514
Acceso en línea:http://hdl.handle.net/10230/32514
http://dx.doi.org/10.1080/21541264.2016.1268245
Access Level:acceso abierto
Palabra clave:Alternative splicing
Cancer
Biomarkers
RNA processing
Splicing regulation
Therapy
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spelling The role of alternative splicing in cancerSingh, Babita, 1986-Eyras Jiménez, EduardoAlternative splicingCancerBiomarkersRNA processingSplicing regulationTherapyThe functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types. Some of these alterations have been linked to tumor progression, metastasis, therapy resistance, and other oncogenic processes. Here, we describe the different mechanisms that drive splicing changes in tumors and their impact in cancer. Motivated by the current evidence, we propose a model whereby a subset of the splicing patterns contributes to the definition of specific tumor phenotypes, and may hold potential for the development of novel clinical biomarkers and therapeutic approaches.This work was supported by the MINECO and FEDER (BIO2014–52566-R) and AGAUR (SGR2014–1121).Taylor & Francis (Routledge)201720172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/32514http://dx.doi.org/10.1080/21541264.2016.1268245reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésTranscription. 2017;8(2):91-8info:eu-repo/grantAgreement/ES/1PE/BIO2014-52566-R© 2017 The Author(s). Published with license by Taylor & Francis© Babita Singh and Eduardo Eyras. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/325142026-05-29T05:05:01Z
dc.title.none.fl_str_mv The role of alternative splicing in cancer
title The role of alternative splicing in cancer
spellingShingle The role of alternative splicing in cancer
Singh, Babita, 1986-
Alternative splicing
Cancer
Biomarkers
RNA processing
Splicing regulation
Therapy
title_short The role of alternative splicing in cancer
title_full The role of alternative splicing in cancer
title_fullStr The role of alternative splicing in cancer
title_full_unstemmed The role of alternative splicing in cancer
title_sort The role of alternative splicing in cancer
dc.creator.none.fl_str_mv Singh, Babita, 1986-
Eyras Jiménez, Eduardo
author Singh, Babita, 1986-
author_facet Singh, Babita, 1986-
Eyras Jiménez, Eduardo
author_role author
author2 Eyras Jiménez, Eduardo
author2_role author
dc.subject.none.fl_str_mv Alternative splicing
Cancer
Biomarkers
RNA processing
Splicing regulation
Therapy
topic Alternative splicing
Cancer
Biomarkers
RNA processing
Splicing regulation
Therapy
description The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types. Some of these alterations have been linked to tumor progression, metastasis, therapy resistance, and other oncogenic processes. Here, we describe the different mechanisms that drive splicing changes in tumors and their impact in cancer. Motivated by the current evidence, we propose a model whereby a subset of the splicing patterns contributes to the definition of specific tumor phenotypes, and may hold potential for the development of novel clinical biomarkers and therapeutic approaches.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/32514
http://dx.doi.org/10.1080/21541264.2016.1268245
url http://hdl.handle.net/10230/32514
http://dx.doi.org/10.1080/21541264.2016.1268245
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Transcription. 2017;8(2):91-8
info:eu-repo/grantAgreement/ES/1PE/BIO2014-52566-R
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis (Routledge)
publisher.none.fl_str_mv Taylor & Francis (Routledge)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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