Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation

Liver transplantation (LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma (HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to 85%of 3- to 4-year actuarial survival rates are achieved, but up to...

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Autores: Citores, María J., Lucena De la Poza, José Luis, Fuente, Sara de la, Cuervas-Mons Martínez, Valentín
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/691181
Acceso en línea:http://hdl.handle.net/10486/691181
https://dx.doi.org/10.4254/wjh.v11.i1.50
Access Level:acceso abierto
Palabra clave:Hepatocellular carcinoma
Liver transplantation
Recurrence
Selection criteria
Prognostic score
Biomarker
Alpha-fetoprotein
Systemic inflammatory marker
Medicina
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spelling Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantationCitores, María J.Lucena De la Poza, José LuisFuente, Sara de laCuervas-Mons Martínez, ValentínHepatocellular carcinomaLiver transplantationRecurrenceSelection criteriaPrognostic scoreBiomarkerAlpha-fetoproteinSystemic inflammatory markerMedicinaLiver transplantation (LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma (HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to 85%of 3- to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma- carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation. These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoralBaishideng Publishing Group Inc.Departamento de MedicinaFacultad de Medicina20192019-01-27research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/691181https://dx.doi.org/10.4254/wjh.v11.i1.50reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6911812026-06-23T12:46:27Z
dc.title.none.fl_str_mv Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
title Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
spellingShingle Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
Citores, María J.
Hepatocellular carcinoma
Liver transplantation
Recurrence
Selection criteria
Prognostic score
Biomarker
Alpha-fetoprotein
Systemic inflammatory marker
Medicina
title_short Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
title_full Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
title_fullStr Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
title_full_unstemmed Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
title_sort Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
dc.creator.none.fl_str_mv Citores, María J.
Lucena De la Poza, José Luis
Fuente, Sara de la
Cuervas-Mons Martínez, Valentín
author Citores, María J.
author_facet Citores, María J.
Lucena De la Poza, José Luis
Fuente, Sara de la
Cuervas-Mons Martínez, Valentín
author_role author
author2 Lucena De la Poza, José Luis
Fuente, Sara de la
Cuervas-Mons Martínez, Valentín
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv Hepatocellular carcinoma
Liver transplantation
Recurrence
Selection criteria
Prognostic score
Biomarker
Alpha-fetoprotein
Systemic inflammatory marker
Medicina
topic Hepatocellular carcinoma
Liver transplantation
Recurrence
Selection criteria
Prognostic score
Biomarker
Alpha-fetoprotein
Systemic inflammatory marker
Medicina
description Liver transplantation (LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma (HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to 85%of 3- to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma- carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation. These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-27
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/691181
https://dx.doi.org/10.4254/wjh.v11.i1.50
url http://hdl.handle.net/10486/691181
https://dx.doi.org/10.4254/wjh.v11.i1.50
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group Inc.
publisher.none.fl_str_mv Baishideng Publishing Group Inc.
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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