The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thal...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/183906 |
| Acceso en línea: | https://hdl.handle.net/2445/183906 |
| Access Level: | acceso abierto |
| Palabra clave: | Tàlem (Anatomia) Conducta compulsiva Thalamus Compulsive behavior |
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| dc.title.none.fl_str_mv |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder |
| title |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder |
| spellingShingle |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder Weeland, Cees J. Tàlem (Anatomia) Conducta compulsiva Thalamus Compulsive behavior |
| title_short |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder |
| title_full |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder |
| title_fullStr |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder |
| title_full_unstemmed |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder |
| title_sort |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder |
| dc.creator.none.fl_str_mv |
Weeland, Cees J. Kasprzak, Selina Joode, Niels T. de Abe, Yoshinari Alonso, Pino Ameis, Stephanie H. Anticevic, Alan Arnold, Paul D. Balachander, Srinivas Banaj, Nerisa Bargalló Alabart, Núria Venkatasubramanian, G. Walitza, Susanne Wang, Jicai Wang, Zhen Watanabe, Anri Wolters, Lidewij H. Xu, Xiufeng Yun, Je-Yeon Zhao, Qing White, Tonya Thompson, Paul M. Stein, Dan J. Heuvel, Odile A. van den Vriend, Chris ENIGMA-OCD working group Batistuzzo, Marcelo C. Benedetti, Francesco Beucke, Jan C. Bollettini, Irene Brecke, Vilde Brem, Silvia Cappi, Carolina Cheng, Yuqi Cho, Kang Ik K. Costa, Daniel L. C. Dallaspezia, Sara Denys, Damiaan Eng, Goi Khia Ferreira, Sónia Feusner, Jamie D. Fontaine, Martine Fouche, Jean Paul Grazioplene, Rachael G. Gruner, Patricia He, Mengxin Hirano, Yoshiyuki Hoexter, Marcelo Q. Huyser, Chaim Hu, Hao Jaspers-Fayer, Fern Kathmann, Norbert Kaufmann, Christian Kim, Minah Koch, Kathrin Bin Kwak, Yoo Kwon, Jun Soo Lázaro García, Luisa Li, Chiang-Shan R. Lochner, Christine Marsh, Rachel Martínez Zalacaín, Ignacio Mataix-Cols, David Menchón, Jose M. Minnuzi, Luciano Moreira, Pedro Silva Morgado, Pedro Nakagawa, Akiko Nakamae, Takashi Narayanaswamy, Janardhanan C. Nurmi, Erika L. Ortiz, Ana Encarnación Pariente, Jose Carlos Piacentini, John Picó Pérez, Maria Piras, Fabrizio Piras, Federica Pittenger, Christopher Reddy, Y. C. Janardhan Rodriguez Manrique, Daniela Sakai, Yuki Shimizu, Eiji Shivakumar, Venkataram Simpson, Helen Blair Soreni, Noam Soriano Mas, Carles Sousa, Nuno Spalletta, Gianfranco Stern, Emily R. Stevens, Michael C. Stewart, S. Evelyn Szeszko, Philip R. Takahashi, Jumpei Tanamatis, Tais Tang, Jinsong Thorsen, Anders Lillevik Tolin, David Werf, Ysbrand D. van der Van Marle, Hein Wingen, Guido A. van Vecchio, Daniela |
| author |
Weeland, Cees J. |
| author_facet |
Weeland, Cees J. Kasprzak, Selina Joode, Niels T. de Abe, Yoshinari Alonso, Pino Ameis, Stephanie H. Anticevic, Alan Arnold, Paul D. Balachander, Srinivas Banaj, Nerisa Bargalló Alabart, Núria Venkatasubramanian, G. Walitza, Susanne Wang, Jicai Wang, Zhen Watanabe, Anri Wolters, Lidewij H. Xu, Xiufeng Yun, Je-Yeon Zhao, Qing White, Tonya Thompson, Paul M. Stein, Dan J. Heuvel, Odile A. van den Vriend, Chris ENIGMA-OCD working group Batistuzzo, Marcelo C. Benedetti, Francesco Beucke, Jan C. Bollettini, Irene Brecke, Vilde Brem, Silvia Cappi, Carolina Cheng, Yuqi Cho, Kang Ik K. Costa, Daniel L. C. Dallaspezia, Sara Denys, Damiaan Eng, Goi Khia Ferreira, Sónia Feusner, Jamie D. Fontaine, Martine Fouche, Jean Paul Grazioplene, Rachael G. Gruner, Patricia He, Mengxin Hirano, Yoshiyuki Hoexter, Marcelo Q. Huyser, Chaim Hu, Hao Jaspers-Fayer, Fern Kathmann, Norbert Kaufmann, Christian Kim, Minah Koch, Kathrin Bin Kwak, Yoo Kwon, Jun Soo Lázaro García, Luisa Li, Chiang-Shan R. Lochner, Christine Marsh, Rachel Martínez Zalacaín, Ignacio Mataix-Cols, David Menchón, Jose M. Minnuzi, Luciano Moreira, Pedro Silva Morgado, Pedro Nakagawa, Akiko Nakamae, Takashi Narayanaswamy, Janardhanan C. Nurmi, Erika L. Ortiz, Ana Encarnación Pariente, Jose Carlos Piacentini, John Picó Pérez, Maria Piras, Fabrizio Piras, Federica Pittenger, Christopher Reddy, Y. C. Janardhan Rodriguez Manrique, Daniela Sakai, Yuki Shimizu, Eiji Shivakumar, Venkataram Simpson, Helen Blair Soreni, Noam Soriano Mas, Carles Sousa, Nuno Spalletta, Gianfranco Stern, Emily R. Stevens, Michael C. Stewart, S. Evelyn Szeszko, Philip R. Takahashi, Jumpei Tanamatis, Tais Tang, Jinsong Thorsen, Anders Lillevik Tolin, David Werf, Ysbrand D. van der Van Marle, Hein Wingen, Guido A. van Vecchio, Daniela |
| author_role |
author |
| author2 |
Kasprzak, Selina Joode, Niels T. de Abe, Yoshinari Alonso, Pino Ameis, Stephanie H. Anticevic, Alan Arnold, Paul D. Balachander, Srinivas Banaj, Nerisa Bargalló Alabart, Núria Venkatasubramanian, G. Walitza, Susanne Wang, Jicai Wang, Zhen Watanabe, Anri Wolters, Lidewij H. Xu, Xiufeng Yun, Je-Yeon Zhao, Qing White, Tonya Thompson, Paul M. Stein, Dan J. Heuvel, Odile A. van den Vriend, Chris ENIGMA-OCD working group Batistuzzo, Marcelo C. Benedetti, Francesco Beucke, Jan C. Bollettini, Irene Brecke, Vilde Brem, Silvia Cappi, Carolina Cheng, Yuqi Cho, Kang Ik K. Costa, Daniel L. C. Dallaspezia, Sara Denys, Damiaan Eng, Goi Khia Ferreira, Sónia Feusner, Jamie D. Fontaine, Martine Fouche, Jean Paul Grazioplene, Rachael G. Gruner, Patricia He, Mengxin Hirano, Yoshiyuki Hoexter, Marcelo Q. Huyser, Chaim Hu, Hao Jaspers-Fayer, Fern Kathmann, Norbert Kaufmann, Christian Kim, Minah Koch, Kathrin Bin Kwak, Yoo Kwon, Jun Soo Lázaro García, Luisa Li, Chiang-Shan R. Lochner, Christine Marsh, Rachel Martínez Zalacaín, Ignacio Mataix-Cols, David Menchón, Jose M. Minnuzi, Luciano Moreira, Pedro Silva Morgado, Pedro Nakagawa, Akiko Nakamae, Takashi Narayanaswamy, Janardhanan C. Nurmi, Erika L. Ortiz, Ana Encarnación Pariente, Jose Carlos Piacentini, John Picó Pérez, Maria Piras, Fabrizio Piras, Federica Pittenger, Christopher Reddy, Y. C. Janardhan Rodriguez Manrique, Daniela Sakai, Yuki Shimizu, Eiji Shivakumar, Venkataram Simpson, Helen Blair Soreni, Noam Soriano Mas, Carles Sousa, Nuno Spalletta, Gianfranco Stern, Emily R. Stevens, Michael C. Stewart, S. Evelyn Szeszko, Philip R. Takahashi, Jumpei Tanamatis, Tais Tang, Jinsong Thorsen, Anders Lillevik Tolin, David Werf, Ysbrand D. van der Van Marle, Hein Wingen, Guido A. van Vecchio, Daniela |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Tàlem (Anatomia) Conducta compulsiva Thalamus Compulsive behavior |
| topic |
Tàlem (Anatomia) Conducta compulsiva Thalamus Compulsive behavior |
| description |
Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T-1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered (https://osf.io/73dvy) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = -0.15 to -0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/183906 |
| url |
https://hdl.handle.net/2445/183906 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1038/s41398-022-01823-2 Translational Psychiatry, 2022, vol 12, num 1 https://doi.org/10.1038/s41398-022-01823-2 |
| dc.rights.none.fl_str_mv |
cc by (c) Weeland, Cees J. et al, 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by (c) Weeland, Cees J. et al, 2022 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer Science and Business Media LLC |
| publisher.none.fl_str_mv |
Springer Science and Business Media LLC |
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Articles publicats en revistes (Ciències Clíniques) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
| reponame_str |
Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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1869418193342169088 |
| spelling |
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorderWeeland, Cees J.Kasprzak, SelinaJoode, Niels T. deAbe, YoshinariAlonso, PinoAmeis, Stephanie H.Anticevic, AlanArnold, Paul D.Balachander, SrinivasBanaj, NerisaBargalló Alabart, NúriaVenkatasubramanian, G.Walitza, SusanneWang, JicaiWang, ZhenWatanabe, AnriWolters, Lidewij H.Xu, XiufengYun, Je-YeonZhao, QingWhite, TonyaThompson, Paul M.Stein, Dan J.Heuvel, Odile A. van denVriend, ChrisENIGMA-OCD working groupBatistuzzo, Marcelo C.Benedetti, FrancescoBeucke, Jan C.Bollettini, IreneBrecke, VildeBrem, SilviaCappi, CarolinaCheng, YuqiCho, Kang Ik K.Costa, Daniel L. C.Dallaspezia, SaraDenys, DamiaanEng, Goi KhiaFerreira, SóniaFeusner, Jamie D.Fontaine, MartineFouche, Jean PaulGrazioplene, Rachael G.Gruner, PatriciaHe, MengxinHirano, YoshiyukiHoexter, Marcelo Q.Huyser, ChaimHu, HaoJaspers-Fayer, FernKathmann, NorbertKaufmann, ChristianKim, MinahKoch, KathrinBin Kwak, YooKwon, Jun SooLázaro García, LuisaLi, Chiang-Shan R.Lochner, ChristineMarsh, RachelMartínez Zalacaín, IgnacioMataix-Cols, DavidMenchón, Jose M.Minnuzi, LucianoMoreira, Pedro SilvaMorgado, PedroNakagawa, AkikoNakamae, TakashiNarayanaswamy, Janardhanan C.Nurmi, Erika L.Ortiz, Ana EncarnaciónPariente, Jose CarlosPiacentini, JohnPicó Pérez, MariaPiras, FabrizioPiras, FedericaPittenger, ChristopherReddy, Y. C. JanardhanRodriguez Manrique, DanielaSakai, YukiShimizu, EijiShivakumar, VenkataramSimpson, Helen BlairSoreni, NoamSoriano Mas, CarlesSousa, NunoSpalletta, GianfrancoStern, Emily R.Stevens, Michael C.Stewart, S. EvelynSzeszko, Philip R.Takahashi, JumpeiTanamatis, TaisTang, JinsongThorsen, Anders LillevikTolin, DavidWerf, Ysbrand D. van derVan Marle, HeinWingen, Guido A. vanVecchio, DanielaTàlem (Anatomia)Conducta compulsivaThalamusCompulsive behaviorLarger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T-1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered (https://osf.io/73dvy) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = -0.15 to -0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.Springer Science and Business Media LLC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183906Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41398-022-01823-2Translational Psychiatry, 2022, vol 12, num 1https://doi.org/10.1038/s41398-022-01823-2cc by (c) Weeland, Cees J. et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1839062026-05-27T06:46:51Z |
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15,300724 |