Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications
Oxidative stress is present in pregnancy complications. However, it is unknown if early maternal antioxidant status could influence later development of complications. The use of assisted reproduction techniques (ART) is rising due to the delay of first pregnancy and there is scarce information on i...
| Autores: | , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/690823 |
| Acceso en línea: | http://hdl.handle.net/10486/690823 https://dx.doi.org/10.1016/j.placenta.2016.08.090 |
| Access Level: | acceso abierto |
| Palabra clave: | Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
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Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complicationsRamiro Cortijo, DavidHerrera, TeresaRodríguez Rodríguez, PilarLópez de Pablo León, Ángel LuisCalle Fernández-Miranda, María de laLópez Giménez, RosarioMora Urda, Ana IsabelGutiérrez-Arzapalo, Perla Y.Gómez-Rioja, RubénAguilera Gutiérrez, YolandaMartín Cabrejas, M. ÁngelesCondezo-Hoyos, LuisGonzález Enguita, María del CarmenMontero López, María del PilarMoreno Jiménez, BernardoArribas Rodríguez, Silvia MagdalenaAntioxidantsObstetric complicationsPlasmaPregnancyBiomarkerMedicinaOxidative stress is present in pregnancy complications. However, it is unknown if early maternal antioxidant status could influence later development of complications. The use of assisted reproduction techniques (ART) is rising due to the delay of first pregnancy and there is scarce information on its influence on oxidative balance. Objective To assess the possible relationship between maternal plasma antioxidant status in first trimester of gestation with later development of pregnancy complications, evaluating the influence of ART and nutrition. Methods Plasma from 98 healthy pregnant women was obtained at week 10, nutrition questionnaires filled and women were followed until delivery. We evaluated biomarkers of oxidative damage (carbonyls, malondialdehyde-MDA), antioxidants (thiols, reduced glutathione, phenolic compounds, catalase and superoxide dismutase activities) by spectrophotometry/fluorimetry and melatonin (ELISA). Antioxidant status score (Antiox-S) was calculated as the computation of antioxidants. Diet-antioxidants relationship was evaluated through multiple correspondence analysis. Results Melatonin and carbonyls exhibited a negative correlation. No difference in oxidative damage was found between groups, but Antiox-S was significantly lower in women who developed complications. No differences in oxidative damage or Antiox-S were found between ART and no-ART pregnancies. High consumption of foods of vegetable origin cluster with high plasma levels of phenolic compounds and with high Antiox-S. Conclusions In early normal gestation, low plasma antioxidant status, assessed through a global score, associates with later development of pregnancy complications. Larger population studies could help to determine the value of Antiox-S as predictive tool and the relevance of nutrition on maternal antioxidant statusElsevierDepartamento de Obstetricia y GinecologíaDepartamento de BiologíaDepartamento de FisiologíaDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaDepartamento de Psicología Biológica y de la SaludDepartamento de Química OrgánicaFacultad de PsicologíaUAM. Departamento de Química Agrícola20162016-08-30research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/690823https://dx.doi.org/10.1016/j.placenta.2016.08.090reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6908232026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| spellingShingle |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications Ramiro Cortijo, David Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
| title_short |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_full |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_fullStr |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_full_unstemmed |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_sort |
Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| dc.creator.none.fl_str_mv |
Ramiro Cortijo, David Herrera, Teresa Rodríguez Rodríguez, Pilar López de Pablo León, Ángel Luis Calle Fernández-Miranda, María de la López Giménez, Rosario Mora Urda, Ana Isabel Gutiérrez-Arzapalo, Perla Y. Gómez-Rioja, Rubén Aguilera Gutiérrez, Yolanda Martín Cabrejas, M. Ángeles Condezo-Hoyos, Luis González Enguita, María del Carmen Montero López, María del Pilar Moreno Jiménez, Bernardo Arribas Rodríguez, Silvia Magdalena |
| author |
Ramiro Cortijo, David |
| author_facet |
Ramiro Cortijo, David Herrera, Teresa Rodríguez Rodríguez, Pilar López de Pablo León, Ángel Luis Calle Fernández-Miranda, María de la López Giménez, Rosario Mora Urda, Ana Isabel Gutiérrez-Arzapalo, Perla Y. Gómez-Rioja, Rubén Aguilera Gutiérrez, Yolanda Martín Cabrejas, M. Ángeles Condezo-Hoyos, Luis González Enguita, María del Carmen Montero López, María del Pilar Moreno Jiménez, Bernardo Arribas Rodríguez, Silvia Magdalena |
| author_role |
author |
| author2 |
Herrera, Teresa Rodríguez Rodríguez, Pilar López de Pablo León, Ángel Luis Calle Fernández-Miranda, María de la López Giménez, Rosario Mora Urda, Ana Isabel Gutiérrez-Arzapalo, Perla Y. Gómez-Rioja, Rubén Aguilera Gutiérrez, Yolanda Martín Cabrejas, M. Ángeles Condezo-Hoyos, Luis González Enguita, María del Carmen Montero López, María del Pilar Moreno Jiménez, Bernardo Arribas Rodríguez, Silvia Magdalena |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Obstetricia y Ginecología Departamento de Biología Departamento de Fisiología Departamento de Medicina Preventiva y Salud Pública y Microbiología Departamento de Psicología Biológica y de la Salud Departamento de Química Orgánica Facultad de Psicología UAM. Departamento de Química Agrícola |
| dc.subject.none.fl_str_mv |
Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
| topic |
Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
| description |
Oxidative stress is present in pregnancy complications. However, it is unknown if early maternal antioxidant status could influence later development of complications. The use of assisted reproduction techniques (ART) is rising due to the delay of first pregnancy and there is scarce information on its influence on oxidative balance. Objective To assess the possible relationship between maternal plasma antioxidant status in first trimester of gestation with later development of pregnancy complications, evaluating the influence of ART and nutrition. Methods Plasma from 98 healthy pregnant women was obtained at week 10, nutrition questionnaires filled and women were followed until delivery. We evaluated biomarkers of oxidative damage (carbonyls, malondialdehyde-MDA), antioxidants (thiols, reduced glutathione, phenolic compounds, catalase and superoxide dismutase activities) by spectrophotometry/fluorimetry and melatonin (ELISA). Antioxidant status score (Antiox-S) was calculated as the computation of antioxidants. Diet-antioxidants relationship was evaluated through multiple correspondence analysis. Results Melatonin and carbonyls exhibited a negative correlation. No difference in oxidative damage was found between groups, but Antiox-S was significantly lower in women who developed complications. No differences in oxidative damage or Antiox-S were found between ART and no-ART pregnancies. High consumption of foods of vegetable origin cluster with high plasma levels of phenolic compounds and with high Antiox-S. Conclusions In early normal gestation, low plasma antioxidant status, assessed through a global score, associates with later development of pregnancy complications. Larger population studies could help to determine the value of Antiox-S as predictive tool and the relevance of nutrition on maternal antioxidant status |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2016-08-30 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/690823 https://dx.doi.org/10.1016/j.placenta.2016.08.090 |
| url |
http://hdl.handle.net/10486/690823 https://dx.doi.org/10.1016/j.placenta.2016.08.090 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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