eggNOG 6.0: enabling comparative genomics across 12 535 organisms

The eggNOG (evolutionary gene genealogy Nonsupervised Orthologous Groups) database is a bioinformatics resource providing orthology data and comprehensive functional information for organisms from all domains of life. Here, we present a major update of the database and website (version 6.0), which i...

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Autores: Hernandez-Plaza, A., Szklarczyk, D., Botas, J., Cantalapiedra, C. P., Giner Lamia, Joaquín
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/178257
Acesso em linha:https://hdl.handle.net/11441/178257
https://doi.org/10.1093/nar/gkac1022
Access Level:acceso abierto
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spelling eggNOG 6.0: enabling comparative genomics across 12 535 organismsHernandez-Plaza, A.Szklarczyk, D.Botas, J.Cantalapiedra, C. P.Giner Lamia, JoaquínThe eggNOG (evolutionary gene genealogy Nonsupervised Orthologous Groups) database is a bioinformatics resource providing orthology data and comprehensive functional information for organisms from all domains of life. Here, we present a major update of the database and website (version 6.0), which increases the number of covered organisms to 12 535 reference species, expands functional annotations, and implements new functionality. In total, eggNOG 6.0 provides a hierarchy of over 17M orthologous groups (OGs) computed at 1601 taxonomic levels, spanning 10 756 bacterial, 457 archaeal and 1322 eukaryotic organisms. OGs have been thoroughly annotated using recent knowledge from functional databases, including KEGG, Gene Ontology, UniProtKB, BiGG, CAZy, CARD, PFAM and SMART. eggNOG also offers phylogenetic trees for all OGs, maximising utility and versatility for end users while allowing researchers to investigate the evolutionary history of speciation and duplication events as well as the phylogenetic distribution of functional terms within each OG. Furthermore, the eggNOG 6.0 website contains new functionality to mine orthology and functional data with ease, including the possibility of generating phylogenetic profiles for multiple OGs across species or identifying single-copy OGs at custom taxonomic levels. eggNOG 6.0 is available at http://eggnog6.embl.de.Oxford University PressBioquímica Vegetal y Biología MolecularAgencia Estatal de Investigación. EspañaMinisterio de Ciencia, Innovación y Universidades (MICIU). España2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/178257https://doi.org/10.1093/nar/gkac1022reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésNucleic Acids Research, 51 (D1), D389-D394.SEV-2016–0672PTA2019- 017593-IPGC2018-098073-A-I00https://doi.org/10.1093/nar/gkac1022info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1782572026-06-17T12:51:07Z
dc.title.none.fl_str_mv eggNOG 6.0: enabling comparative genomics across 12 535 organisms
title eggNOG 6.0: enabling comparative genomics across 12 535 organisms
spellingShingle eggNOG 6.0: enabling comparative genomics across 12 535 organisms
Hernandez-Plaza, A.
title_short eggNOG 6.0: enabling comparative genomics across 12 535 organisms
title_full eggNOG 6.0: enabling comparative genomics across 12 535 organisms
title_fullStr eggNOG 6.0: enabling comparative genomics across 12 535 organisms
title_full_unstemmed eggNOG 6.0: enabling comparative genomics across 12 535 organisms
title_sort eggNOG 6.0: enabling comparative genomics across 12 535 organisms
dc.creator.none.fl_str_mv Hernandez-Plaza, A.
Szklarczyk, D.
Botas, J.
Cantalapiedra, C. P.
Giner Lamia, Joaquín
author Hernandez-Plaza, A.
author_facet Hernandez-Plaza, A.
Szklarczyk, D.
Botas, J.
Cantalapiedra, C. P.
Giner Lamia, Joaquín
author_role author
author2 Szklarczyk, D.
Botas, J.
Cantalapiedra, C. P.
Giner Lamia, Joaquín
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Bioquímica Vegetal y Biología Molecular
Agencia Estatal de Investigación. España
Ministerio de Ciencia, Innovación y Universidades (MICIU). España
description The eggNOG (evolutionary gene genealogy Nonsupervised Orthologous Groups) database is a bioinformatics resource providing orthology data and comprehensive functional information for organisms from all domains of life. Here, we present a major update of the database and website (version 6.0), which increases the number of covered organisms to 12 535 reference species, expands functional annotations, and implements new functionality. In total, eggNOG 6.0 provides a hierarchy of over 17M orthologous groups (OGs) computed at 1601 taxonomic levels, spanning 10 756 bacterial, 457 archaeal and 1322 eukaryotic organisms. OGs have been thoroughly annotated using recent knowledge from functional databases, including KEGG, Gene Ontology, UniProtKB, BiGG, CAZy, CARD, PFAM and SMART. eggNOG also offers phylogenetic trees for all OGs, maximising utility and versatility for end users while allowing researchers to investigate the evolutionary history of speciation and duplication events as well as the phylogenetic distribution of functional terms within each OG. Furthermore, the eggNOG 6.0 website contains new functionality to mine orthology and functional data with ease, including the possibility of generating phylogenetic profiles for multiple OGs across species or identifying single-copy OGs at custom taxonomic levels. eggNOG 6.0 is available at http://eggnog6.embl.de.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/178257
https://doi.org/10.1093/nar/gkac1022
url https://hdl.handle.net/11441/178257
https://doi.org/10.1093/nar/gkac1022
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nucleic Acids Research, 51 (D1), D389-D394.
SEV-2016–0672
PTA2019- 017593-I
PGC2018-098073-A-I00
https://doi.org/10.1093/nar/gkac1022
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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