Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model

Alzheimer’s disease (AD), the most common form of dementia, is becoming a global health problem and public health priority. In the advanced stages of AD, besides the initial cognitive symptoms, behavioral problems, particularly agitation and aggressiveness, become prevalent in AD patients. These non...

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Detalhes bibliográficos
Autores: Muñoz Montero, Alicia, de Pascual, Ricardo, Sáez-Mas, Anabel, Colmena, Inés, Gandía Juan, Luis
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universidad Autónoma de Madrid
Repositório:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglês
OAI Identifier:oai:repositorio.uam.es:10486/706600
Acesso em linha:http://hdl.handle.net/10486/706600
https://dx.doi.org/10.3390/biology11040511
Access Level:Acceso aberto
Palavra-chave:3xTg mouse model
Alzheimer’s disease
autocrine-paracrine modulation
chromaffin cell
sympathoadrenal axis
voltage-dependent calcium channels
Medicina
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spelling Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse modelMuñoz Montero, Aliciade Pascual, RicardoSáez-Mas, AnabelColmena, InésGandía Juan, Luis3xTg mouse modelAlzheimer’s diseaseautocrine-paracrine modulationchromaffin cellsympathoadrenal axisvoltage-dependent calcium channelsMedicinaAlzheimer’s disease (AD), the most common form of dementia, is becoming a global health problem and public health priority. In the advanced stages of AD, besides the initial cognitive symptoms, behavioral problems, particularly agitation and aggressiveness, become prevalent in AD patients. These non-cognitive symptoms could be related to a noradrenergic overactivation. In this study, we used chromaffin cells (CCs) isolated from the adrenal gland of 3xTg AD model mice to characterize potential alterations in the autocrine-paracrine modulation of voltage-dependent calcium channels (VDCCs), which in turn serve to regulate the release of catecholamines. We used mice at the presymptomatic stage (2 months) and mice over 12 months of age, when AD-related cognitive impairment was fully established. We found that the modulation of inward currents through VDCCs induced by extracellular ATP was stronger in CCs isolated from the adrenal medulla of 3xTg mice older than 12 months of age, an effect likely related to disease progression as it was not observed in CCs from age-matched WT mice. This enhanced modulation leads to increased catecholamine release in response to stressful situations, which may explain the non-cognitive behavioral problems found in AD patientsThis research was funded by the Spanish Ministerio de Economía y Competitividad (MINECO), grant number SAF2017-78892-R. Additionally, A.M.M. has a fellowship from the Spanish Ministerio de Ciencia, Innovación y Universidades (Ref. FPU2016/02559)MDPIDepartamento de FarmacologíaDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaFacultad de Medicina20222022-03-26research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/706600https://dx.doi.org/10.3390/biology11040511reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7066002026-06-23T12:46:27Z
dc.title.none.fl_str_mv Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
title Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
spellingShingle Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
Muñoz Montero, Alicia
3xTg mouse model
Alzheimer’s disease
autocrine-paracrine modulation
chromaffin cell
sympathoadrenal axis
voltage-dependent calcium channels
Medicina
title_short Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
title_full Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
title_fullStr Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
title_full_unstemmed Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
title_sort Alterations of the sympathoadrenal axis related to the development of alzheimer’s disease in the 3xTg mouse model
dc.creator.none.fl_str_mv Muñoz Montero, Alicia
de Pascual, Ricardo
Sáez-Mas, Anabel
Colmena, Inés
Gandía Juan, Luis
author Muñoz Montero, Alicia
author_facet Muñoz Montero, Alicia
de Pascual, Ricardo
Sáez-Mas, Anabel
Colmena, Inés
Gandía Juan, Luis
author_role author
author2 de Pascual, Ricardo
Sáez-Mas, Anabel
Colmena, Inés
Gandía Juan, Luis
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Farmacología
Departamento de Medicina Preventiva y Salud Pública y Microbiología
Facultad de Medicina
dc.subject.none.fl_str_mv 3xTg mouse model
Alzheimer’s disease
autocrine-paracrine modulation
chromaffin cell
sympathoadrenal axis
voltage-dependent calcium channels
Medicina
topic 3xTg mouse model
Alzheimer’s disease
autocrine-paracrine modulation
chromaffin cell
sympathoadrenal axis
voltage-dependent calcium channels
Medicina
description Alzheimer’s disease (AD), the most common form of dementia, is becoming a global health problem and public health priority. In the advanced stages of AD, besides the initial cognitive symptoms, behavioral problems, particularly agitation and aggressiveness, become prevalent in AD patients. These non-cognitive symptoms could be related to a noradrenergic overactivation. In this study, we used chromaffin cells (CCs) isolated from the adrenal gland of 3xTg AD model mice to characterize potential alterations in the autocrine-paracrine modulation of voltage-dependent calcium channels (VDCCs), which in turn serve to regulate the release of catecholamines. We used mice at the presymptomatic stage (2 months) and mice over 12 months of age, when AD-related cognitive impairment was fully established. We found that the modulation of inward currents through VDCCs induced by extracellular ATP was stronger in CCs isolated from the adrenal medulla of 3xTg mice older than 12 months of age, an effect likely related to disease progression as it was not observed in CCs from age-matched WT mice. This enhanced modulation leads to increased catecholamine release in response to stressful situations, which may explain the non-cognitive behavioral problems found in AD patients
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-26
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/706600
https://dx.doi.org/10.3390/biology11040511
url http://hdl.handle.net/10486/706600
https://dx.doi.org/10.3390/biology11040511
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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