Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery

Background: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infec...

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Autores: Badia, Josep M.|||0000-0003-2928-5233, Flores-Yelamos, Miriam|||0000-0002-2640-9117, Vázquez Fariñas, Ana|||0000-0001-6732-1667, Arroyo-Garcia, Nares|||0000-0002-7345-6143, Puig-Asensio, Mireia|||0000-0002-0722-2218, Parés, David|||0000-0001-8233-4888, Pera, Miguel|||0000-0001-7764-6481, López-Contreras, Joaquín|||0000-0002-3166-4016, Limón, Enric|||0000-0002-5396-1521, Pujol, Miquel|||0000-0002-6475-6208
Tipo de recurso: informe técnico
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255200
Acceso en línea:https://ddd.uab.cat/record/255200
https://dx.doi.org/urn:doi:10.3390/jcm10235636
Access Level:acceso abierto
Palabra clave:Colorectal surgery
Surgical site infection
Surgical wound infection
Oral antibiotic prophylaxis
Mechanical bowel preparation
Preventative measures
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spelling Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgeryresults of a pragmatic cohort study in CataloniaBadia, Josep M.|||0000-0003-2928-5233Flores-Yelamos, Miriam|||0000-0002-2640-9117Vázquez Fariñas, Ana|||0000-0001-6732-1667Arroyo-Garcia, Nares|||0000-0002-7345-6143Puig-Asensio, Mireia|||0000-0002-0722-2218Parés, David|||0000-0001-8233-4888Pera, Miguel|||0000-0001-7764-6481López-Contreras, Joaquín|||0000-0002-3166-4016Limón, Enric|||0000-0002-5396-1521Pujol, Miquel|||0000-0002-6475-6208Colorectal surgerySurgical site infectionSurgical wound infectionOral antibiotic prophylaxisMechanical bowel preparationPreventative measuresBackground: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: Pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the results, a logistic regression model was established. Results: Out of 34,421 colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI95 0.507-0.573, p < 0.0001). Information about bundle implementation was complete in 61.7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0.555, CI95 0.483-0.638, and OR 0.686, CI95 0.589-0.798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI95 0.494-0.710, and OR 0.771, CI95 0.630-0.944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgery. 22021-01-0120212021-01-01Estudi clínichttp://purl.org/coar/resource_type/c_7877VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/reportapplication/pdfhttps://ddd.uab.cat/record/255200https://dx.doi.org/urn:doi:10.3390/jcm10235636reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2552002026-06-06T12:50:31Z
dc.title.none.fl_str_mv Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
results of a pragmatic cohort study in Catalonia
title Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
spellingShingle Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
Badia, Josep M.|||0000-0003-2928-5233
Colorectal surgery
Surgical site infection
Surgical wound infection
Oral antibiotic prophylaxis
Mechanical bowel preparation
Preventative measures
title_short Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
title_full Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
title_fullStr Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
title_full_unstemmed Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
title_sort Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery
dc.creator.none.fl_str_mv Badia, Josep M.|||0000-0003-2928-5233
Flores-Yelamos, Miriam|||0000-0002-2640-9117
Vázquez Fariñas, Ana|||0000-0001-6732-1667
Arroyo-Garcia, Nares|||0000-0002-7345-6143
Puig-Asensio, Mireia|||0000-0002-0722-2218
Parés, David|||0000-0001-8233-4888
Pera, Miguel|||0000-0001-7764-6481
López-Contreras, Joaquín|||0000-0002-3166-4016
Limón, Enric|||0000-0002-5396-1521
Pujol, Miquel|||0000-0002-6475-6208
author Badia, Josep M.|||0000-0003-2928-5233
author_facet Badia, Josep M.|||0000-0003-2928-5233
Flores-Yelamos, Miriam|||0000-0002-2640-9117
Vázquez Fariñas, Ana|||0000-0001-6732-1667
Arroyo-Garcia, Nares|||0000-0002-7345-6143
Puig-Asensio, Mireia|||0000-0002-0722-2218
Parés, David|||0000-0001-8233-4888
Pera, Miguel|||0000-0001-7764-6481
López-Contreras, Joaquín|||0000-0002-3166-4016
Limón, Enric|||0000-0002-5396-1521
Pujol, Miquel|||0000-0002-6475-6208
author_role author
author2 Flores-Yelamos, Miriam|||0000-0002-2640-9117
Vázquez Fariñas, Ana|||0000-0001-6732-1667
Arroyo-Garcia, Nares|||0000-0002-7345-6143
Puig-Asensio, Mireia|||0000-0002-0722-2218
Parés, David|||0000-0001-8233-4888
Pera, Miguel|||0000-0001-7764-6481
López-Contreras, Joaquín|||0000-0002-3166-4016
Limón, Enric|||0000-0002-5396-1521
Pujol, Miquel|||0000-0002-6475-6208
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Colorectal surgery
Surgical site infection
Surgical wound infection
Oral antibiotic prophylaxis
Mechanical bowel preparation
Preventative measures
topic Colorectal surgery
Surgical site infection
Surgical wound infection
Oral antibiotic prophylaxis
Mechanical bowel preparation
Preventative measures
description Background: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: Pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the results, a logistic regression model was established. Results: Out of 34,421 colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI95 0.507-0.573, p < 0.0001). Information about bundle implementation was complete in 61.7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0.555, CI95 0.483-0.638, and OR 0.686, CI95 0.589-0.798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI95 0.494-0.710, and OR 0.771, CI95 0.630-0.944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgery.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Estudi clínic
http://purl.org/coar/resource_type/c_7877
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/report
format report
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/255200
https://dx.doi.org/urn:doi:10.3390/jcm10235636
url https://ddd.uab.cat/record/255200
https://dx.doi.org/urn:doi:10.3390/jcm10235636
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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