Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications

Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), dur...

Descripción completa

Detalles Bibliográficos
Autores: Perea García, José, Arribas, Julia, Cañete, Ángel, García, Juan Luis, Álvaro, Edurne, Tapial, Sandra, Narváez, Cristina, Vivas, Alfredo, Brandáriz, Lorena, Hernández-Villafranca, Sergio, Rueda, Daniel, Rodríguez, Yolanda, Pérez-García, Jessica, Olmedillas-López, Susana, García Olmo, Damián, Martina Cavestro, Giulia, Urioste, Miguel, Goel, Ajay, González-Sarmiento, Rogelio
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/691707
Acceso en línea:http://hdl.handle.net/10486/691707
https://dx.doi.org/10.3390/cancers11121900
Access Level:acceso abierto
Palabra clave:early-onset colorectal cancer
polyp development
prognosis
follow-up
Medicina
id ES_bd27a054a9feaa5083c7973bb86d79af
oai_identifier_str oai:repositorio.uam.es:10486/691707
network_acronym_str ES
network_name_str España
repository_id_str
spelling Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implicationsPerea García, JoséArribas, JuliaCañete, ÁngelGarcía, Juan LuisÁlvaro, EdurneTapial, SandraNarváez, CristinaVivas, AlfredoBrandáriz, LorenaHernández-Villafranca, SergioRueda, DanielRodríguez, YolandaPérez-García, JessicaOlmedillas-López, SusanaGarcía Olmo, DamiánMartina Cavestro, GiuliaUrioste, MiguelGoel, AjayGonzález-Sarmiento, Rogelioearly-onset colorectal cancerpolyp developmentprognosisfollow-upMedicinaEarly-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P < 5FU) (34%) (these last groups predominantly diagnosed at the earliest stage and with adenomatous polyps (45%)). EOCRC with polyps that developed during the entire follow-up (PDFU group) were mainly located in the right colon (53%), diagnosed in earlier stages, and 75% had a familial history of CRC. Patients developing polyps after the first 5 years (P > 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRCThis work was funded by the Spanish Ministry of Health and ConsumerA airs and FEDER, grant number PI10/00683 and PI16/01650 to J.P.G., PI16/01920 to R.G.S., and PI14/00459 to M.U., and by the National Cancer Institute, National Institutes of Health, grant number R01 CA72851, CA18172, CA184792 and U01 CA187956 to A.G.MDPIDepartamento de CirugíaFacultad de Medicina20192019-11-29research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/691707https://dx.doi.org/10.3390/cancers11121900reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6917072026-06-23T12:46:27Z
dc.title.none.fl_str_mv Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
title Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
spellingShingle Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
Perea García, José
early-onset colorectal cancer
polyp development
prognosis
follow-up
Medicina
title_short Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
title_full Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
title_fullStr Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
title_full_unstemmed Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
title_sort Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications
dc.creator.none.fl_str_mv Perea García, José
Arribas, Julia
Cañete, Ángel
García, Juan Luis
Álvaro, Edurne
Tapial, Sandra
Narváez, Cristina
Vivas, Alfredo
Brandáriz, Lorena
Hernández-Villafranca, Sergio
Rueda, Daniel
Rodríguez, Yolanda
Pérez-García, Jessica
Olmedillas-López, Susana
García Olmo, Damián
Martina Cavestro, Giulia
Urioste, Miguel
Goel, Ajay
González-Sarmiento, Rogelio
author Perea García, José
author_facet Perea García, José
Arribas, Julia
Cañete, Ángel
García, Juan Luis
Álvaro, Edurne
Tapial, Sandra
Narváez, Cristina
Vivas, Alfredo
Brandáriz, Lorena
Hernández-Villafranca, Sergio
Rueda, Daniel
Rodríguez, Yolanda
Pérez-García, Jessica
Olmedillas-López, Susana
García Olmo, Damián
Martina Cavestro, Giulia
Urioste, Miguel
Goel, Ajay
González-Sarmiento, Rogelio
author_role author
author2 Arribas, Julia
Cañete, Ángel
García, Juan Luis
Álvaro, Edurne
Tapial, Sandra
Narváez, Cristina
Vivas, Alfredo
Brandáriz, Lorena
Hernández-Villafranca, Sergio
Rueda, Daniel
Rodríguez, Yolanda
Pérez-García, Jessica
Olmedillas-López, Susana
García Olmo, Damián
Martina Cavestro, Giulia
Urioste, Miguel
Goel, Ajay
González-Sarmiento, Rogelio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Cirugía
Facultad de Medicina
dc.subject.none.fl_str_mv early-onset colorectal cancer
polyp development
prognosis
follow-up
Medicina
topic early-onset colorectal cancer
polyp development
prognosis
follow-up
Medicina
description Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P < 5FU) (34%) (these last groups predominantly diagnosed at the earliest stage and with adenomatous polyps (45%)). EOCRC with polyps that developed during the entire follow-up (PDFU group) were mainly located in the right colon (53%), diagnosed in earlier stages, and 75% had a familial history of CRC. Patients developing polyps after the first 5 years (P > 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRC
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-11-29
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/691707
https://dx.doi.org/10.3390/cancers11121900
url http://hdl.handle.net/10486/691707
https://dx.doi.org/10.3390/cancers11121900
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418176968654848
score 15,301603

Similares en LA Referencia