Electromembrane extraction using deep eutectic solvents as the liquid membrane

In this work, we investigated for the first time hydrophobic deep eutectic solvents (DES) as supported liquid membrane (SLM) for electromembrane extraction (EME). Camphor, coumarin, DL-menthol, and thymol were used as non-ionic DES components. Different DESs compositions were tested, to study system...

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Detalhes bibliográficos
Autores: Hansen, Frederik André, Santigosa-Murillo, Elia, Ramos Payán, María Dolores, Muñoz, María, Leere Øiestad, Elisabeth, Pedersen-Bjergaard, Stig
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/125747
Acesso em linha:https://hdl.handle.net/11441/125747
https://doi.org/10.1016/j.aca.2020.11.044
Access Level:acceso abierto
Palavra-chave:Basic drugs
Electromembrane extraction
Human plasma
Natural deep eutectic solvents
Sample preparation
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spelling Electromembrane extraction using deep eutectic solvents as the liquid membraneHansen, Frederik AndréSantigosa-Murillo, EliaRamos Payán, María DoloresMuñoz, MaríaLeere Øiestad, ElisabethPedersen-Bjergaard, StigBasic drugsElectromembrane extractionHuman plasmaNatural deep eutectic solventsSample preparationIn this work, we investigated for the first time hydrophobic deep eutectic solvents (DES) as supported liquid membrane (SLM) for electromembrane extraction (EME). Camphor, coumarin, DL-menthol, and thymol were used as non-ionic DES components. Different DESs compositions were tested, to study systematically the importance of hydrogen bonding and dispersion/aromatic interactions during mass transfer across the SLM. Unexpectedly, mixtures of coumarin and thymol were highly efficient SLMs, and provided exhaustive or near-exhaustive extraction of non-polar bases, non-polar acids, and polar bases. SLMs with such performance for both bases and acids, in a large polarity window, are not found in current literature. The SLMs were highly aromatic, very strong hydrogen bonding donors, and moderately strong hydrogen bonding acceptors. Aromatic (π type) interactions were apparently very important for transfer of bases, while hydrogen bonding were dominant for acids. EME of six polar basic drugs from plasma, with a coumarin and thymol mixture as SLM, and combined with UHPLC-MS/MS analysis, was evaluated to test the potential for analytical applications. Plasma was diluted 1:1 with phosphate buffer pH 2.0. Calibration curves were linear in the therapeutic ranges (0.970 < R2 < 0.999), recoveries ranged between 47 and 93%, and repeatability was within 1.6–10.7% RSD. The clean-up efficiency was excellent and no matrix effects from plasma were seen. Presence of trace levels of coumarin in the acceptor phase was however found to cause some ion enhancement. Based on the current work, we foresee more research on the use of DES in EME.Agencia de Gestió d’Ajusts Universitaris i the Recerca 2017-SGR-32ElsevierQuímica Analítica2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/125747https://doi.org/10.1016/j.aca.2020.11.044reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésAnalytica Chimica Acta, 1143, 109-116.2017-SGR-32https://doi.org/10.1016/j.aca.2020.11.044info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1257472026-06-17T12:51:07Z
dc.title.none.fl_str_mv Electromembrane extraction using deep eutectic solvents as the liquid membrane
title Electromembrane extraction using deep eutectic solvents as the liquid membrane
spellingShingle Electromembrane extraction using deep eutectic solvents as the liquid membrane
Hansen, Frederik André
Basic drugs
Electromembrane extraction
Human plasma
Natural deep eutectic solvents
Sample preparation
title_short Electromembrane extraction using deep eutectic solvents as the liquid membrane
title_full Electromembrane extraction using deep eutectic solvents as the liquid membrane
title_fullStr Electromembrane extraction using deep eutectic solvents as the liquid membrane
title_full_unstemmed Electromembrane extraction using deep eutectic solvents as the liquid membrane
title_sort Electromembrane extraction using deep eutectic solvents as the liquid membrane
dc.creator.none.fl_str_mv Hansen, Frederik André
Santigosa-Murillo, Elia
Ramos Payán, María Dolores
Muñoz, María
Leere Øiestad, Elisabeth
Pedersen-Bjergaard, Stig
author Hansen, Frederik André
author_facet Hansen, Frederik André
Santigosa-Murillo, Elia
Ramos Payán, María Dolores
Muñoz, María
Leere Øiestad, Elisabeth
Pedersen-Bjergaard, Stig
author_role author
author2 Santigosa-Murillo, Elia
Ramos Payán, María Dolores
Muñoz, María
Leere Øiestad, Elisabeth
Pedersen-Bjergaard, Stig
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Química Analítica
dc.subject.none.fl_str_mv Basic drugs
Electromembrane extraction
Human plasma
Natural deep eutectic solvents
Sample preparation
topic Basic drugs
Electromembrane extraction
Human plasma
Natural deep eutectic solvents
Sample preparation
description In this work, we investigated for the first time hydrophobic deep eutectic solvents (DES) as supported liquid membrane (SLM) for electromembrane extraction (EME). Camphor, coumarin, DL-menthol, and thymol were used as non-ionic DES components. Different DESs compositions were tested, to study systematically the importance of hydrogen bonding and dispersion/aromatic interactions during mass transfer across the SLM. Unexpectedly, mixtures of coumarin and thymol were highly efficient SLMs, and provided exhaustive or near-exhaustive extraction of non-polar bases, non-polar acids, and polar bases. SLMs with such performance for both bases and acids, in a large polarity window, are not found in current literature. The SLMs were highly aromatic, very strong hydrogen bonding donors, and moderately strong hydrogen bonding acceptors. Aromatic (π type) interactions were apparently very important for transfer of bases, while hydrogen bonding were dominant for acids. EME of six polar basic drugs from plasma, with a coumarin and thymol mixture as SLM, and combined with UHPLC-MS/MS analysis, was evaluated to test the potential for analytical applications. Plasma was diluted 1:1 with phosphate buffer pH 2.0. Calibration curves were linear in the therapeutic ranges (0.970 < R2 < 0.999), recoveries ranged between 47 and 93%, and repeatability was within 1.6–10.7% RSD. The clean-up efficiency was excellent and no matrix effects from plasma were seen. Presence of trace levels of coumarin in the acceptor phase was however found to cause some ion enhancement. Based on the current work, we foresee more research on the use of DES in EME.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/125747
https://doi.org/10.1016/j.aca.2020.11.044
url https://hdl.handle.net/11441/125747
https://doi.org/10.1016/j.aca.2020.11.044
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Analytica Chimica Acta, 1143, 109-116.
2017-SGR-32
https://doi.org/10.1016/j.aca.2020.11.044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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