Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog

In the study of central nervous system morphogenesis, the identification of new molecular markers allows us to identify domains along the antero-posterior and dorso-ventral (DV) axes. In the past years, the alar and basal plates of the midbrain have been divided into different domains. The precise l...

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Autores: Martínez-López, Jesús E., Moreno-Bravo, Juan Antonio, Madrigal Verdú, Pilar, Martinez, Salvador, Puelles, Eduardo
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/35381
Acceso en línea:https://hdl.handle.net/11000/35381
Access Level:acceso abierto
Palabra clave:midbrain
Shh
Barhl1
Nhlh1
Six3
basolateral domain
alar-basal boundary
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oai_identifier_str oai:dspace.umh.es:11000/35381
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repository_id_str
spelling Mesencephalic basolateral domain specification is dependent on Sonic HedgehogMartínez-López, Jesús E.Moreno-Bravo, Juan AntonioMadrigal Verdú, PilarMartinez, SalvadorPuelles, EduardomidbrainShhBarhl1Nhlh1Six3basolateral domainalar-basal boundaryIn the study of central nervous system morphogenesis, the identification of new molecular markers allows us to identify domains along the antero-posterior and dorso-ventral (DV) axes. In the past years, the alar and basal plates of the midbrain have been divided into different domains. The precise location of the alar-basal boundary is still under discussion. We have identified Barhl1, Nhlh1 and Six3 as appropriate molecular markers to the adjacent domains of this transition. The description of their expression patterns and the contribution to the different mesencephalic populations corroborated their role in the specification of these domains. We studied the influence of Sonic Hedgehog on these markers and therefore on the specification of these territories. The lack of this morphogen produced severe alterations in the expression pattern of Barhl1 and Nhlh1 with consequent misspecification of the basolateral (BL) domain. Six3 expression was apparently unaffected, however its distribution changed leading to altered basal domains. In this study we confirmed the localization of the alar-basal boundary dorsal to the BL domain and demonstrated that the development of the BL domain highly depends on Shh.Frontiers MediaDepartamentos de la UMH::Histología y AnatomíaInstitutos de la UMH::Instituto de Neurociencias202520252015info:eu-repo/semantics/articleapplication/pdf7application/pdfhttps://hdl.handle.net/11000/35381reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.3389/fnana.2015.00012info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/353812026-05-27T13:36:21Z
dc.title.none.fl_str_mv Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
title Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
spellingShingle Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
Martínez-López, Jesús E.
midbrain
Shh
Barhl1
Nhlh1
Six3
basolateral domain
alar-basal boundary
title_short Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
title_full Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
title_fullStr Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
title_full_unstemmed Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
title_sort Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
dc.creator.none.fl_str_mv Martínez-López, Jesús E.
Moreno-Bravo, Juan Antonio
Madrigal Verdú, Pilar
Martinez, Salvador
Puelles, Eduardo
author Martínez-López, Jesús E.
author_facet Martínez-López, Jesús E.
Moreno-Bravo, Juan Antonio
Madrigal Verdú, Pilar
Martinez, Salvador
Puelles, Eduardo
author_role author
author2 Moreno-Bravo, Juan Antonio
Madrigal Verdú, Pilar
Martinez, Salvador
Puelles, Eduardo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Histología y Anatomía
Institutos de la UMH::Instituto de Neurociencias
dc.subject.none.fl_str_mv midbrain
Shh
Barhl1
Nhlh1
Six3
basolateral domain
alar-basal boundary
topic midbrain
Shh
Barhl1
Nhlh1
Six3
basolateral domain
alar-basal boundary
description In the study of central nervous system morphogenesis, the identification of new molecular markers allows us to identify domains along the antero-posterior and dorso-ventral (DV) axes. In the past years, the alar and basal plates of the midbrain have been divided into different domains. The precise location of the alar-basal boundary is still under discussion. We have identified Barhl1, Nhlh1 and Six3 as appropriate molecular markers to the adjacent domains of this transition. The description of their expression patterns and the contribution to the different mesencephalic populations corroborated their role in the specification of these domains. We studied the influence of Sonic Hedgehog on these markers and therefore on the specification of these territories. The lack of this morphogen produced severe alterations in the expression pattern of Barhl1 and Nhlh1 with consequent misspecification of the basolateral (BL) domain. Six3 expression was apparently unaffected, however its distribution changed leading to altered basal domains. In this study we confirmed the localization of the alar-basal boundary dorsal to the BL domain and demonstrated that the development of the BL domain highly depends on Shh.
publishDate 2015
dc.date.none.fl_str_mv 2015
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/35381
url https://hdl.handle.net/11000/35381
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.3389/fnana.2015.00012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
7
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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