Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction
Objective: This research aims to study structural brain changes in patients with persistent olfactory dysfunctions after coronavirus disease 2019 (COVID-19). Methods: COVID-19 patients were evaluated using T1-weighted and diffusion tensor imaging (DTI) on a 3T MRI scanner, 9.94 ± 3.83 months after C...
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/191736 |
| Acceso en línea: | https://hdl.handle.net/2445/191736 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 Olfacte Cervell Imatges per ressonància magnètica Smell Brain Magnetic resonance imaging |
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Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunctionCampabadal Delgado, AnnaOltra González, JavierJunqué i Plaja, Carme, 1955-Guillen, NúriaBotí, María ÁngelesSala Llonch, RoserMonté Rubio, Gemma C.Lledó, GemaBargalló Alabart, NúriaRami González, LorenaSánchez Valle, RaquelSegura i Fàbregas, BàrbaraCOVID-19OlfacteCervellImatges per ressonància magnèticaCOVID-19SmellBrainMagnetic resonance imagingObjective: This research aims to study structural brain changes in patients with persistent olfactory dysfunctions after coronavirus disease 2019 (COVID-19). Methods: COVID-19 patients were evaluated using T1-weighted and diffusion tensor imaging (DTI) on a 3T MRI scanner, 9.94 ± 3.83 months after COVID-19 diagnosis. Gray matter (GM) voxel-based morphometry was performed using FSL-VBM. Voxelwise statistical analysis of the fractional anisotropy, mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity was carried out with the tract-based spatial statistics in the olfactory system. The smell identification test (UPSIT) was used to classify patients as normal olfaction or olfactory dysfunction groups. Intergroup comparisons between GM and DTI measures were computed, as well as correlations with the UPSIT scores. Results: Forty-eight COVID-19 patients were included in the study. Twenty-three were classified as olfactory dysfunction, and 25 as normal olfaction. The olfactory dysfunction group had lower GM volume in a cluster involving the left amygdala, insular cortex, parahippocampal gyrus, frontal superior and inferior orbital gyri, gyrus rectus, olfactory cortex, caudate, and putamen. This group also showed higher MD values in the genu of the corpus callosum, the orbitofrontal area, the anterior thalamic radiation, and the forceps minor; and higher RD values in the anterior corona radiata, the genu of the corpus callosum, and uncinate fasciculus compared with the normal olfaction group. The UPSIT scores for the whole sample were negatively associated with both MD and RD values (p-value ≤0.05 FWE-corrected). Interpretation: There is decreased GM volume and increased MD in olfactory-related regions explaining prolonged olfactory deficits in post-acute COVID-19 patients.American Neurological Association2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/191736Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/acn3.51710Annals of Clinical and Translational Neurology, 2022https://doi.org/10.1002/acn3.51710cc-by-nc-nd (c) Campabadal, Anna et al., 2022https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1917362026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction |
| title |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction |
| spellingShingle |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction Campabadal Delgado, Anna COVID-19 Olfacte Cervell Imatges per ressonància magnètica COVID-19 Smell Brain Magnetic resonance imaging |
| title_short |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction |
| title_full |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction |
| title_fullStr |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction |
| title_full_unstemmed |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction |
| title_sort |
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction |
| dc.creator.none.fl_str_mv |
Campabadal Delgado, Anna Oltra González, Javier Junqué i Plaja, Carme, 1955- Guillen, Núria Botí, María Ángeles Sala Llonch, Roser Monté Rubio, Gemma C. Lledó, Gema Bargalló Alabart, Núria Rami González, Lorena Sánchez Valle, Raquel Segura i Fàbregas, Bàrbara |
| author |
Campabadal Delgado, Anna |
| author_facet |
Campabadal Delgado, Anna Oltra González, Javier Junqué i Plaja, Carme, 1955- Guillen, Núria Botí, María Ángeles Sala Llonch, Roser Monté Rubio, Gemma C. Lledó, Gema Bargalló Alabart, Núria Rami González, Lorena Sánchez Valle, Raquel Segura i Fàbregas, Bàrbara |
| author_role |
author |
| author2 |
Oltra González, Javier Junqué i Plaja, Carme, 1955- Guillen, Núria Botí, María Ángeles Sala Llonch, Roser Monté Rubio, Gemma C. Lledó, Gema Bargalló Alabart, Núria Rami González, Lorena Sánchez Valle, Raquel Segura i Fàbregas, Bàrbara |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
COVID-19 Olfacte Cervell Imatges per ressonància magnètica COVID-19 Smell Brain Magnetic resonance imaging |
| topic |
COVID-19 Olfacte Cervell Imatges per ressonància magnètica COVID-19 Smell Brain Magnetic resonance imaging |
| description |
Objective: This research aims to study structural brain changes in patients with persistent olfactory dysfunctions after coronavirus disease 2019 (COVID-19). Methods: COVID-19 patients were evaluated using T1-weighted and diffusion tensor imaging (DTI) on a 3T MRI scanner, 9.94 ± 3.83 months after COVID-19 diagnosis. Gray matter (GM) voxel-based morphometry was performed using FSL-VBM. Voxelwise statistical analysis of the fractional anisotropy, mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity was carried out with the tract-based spatial statistics in the olfactory system. The smell identification test (UPSIT) was used to classify patients as normal olfaction or olfactory dysfunction groups. Intergroup comparisons between GM and DTI measures were computed, as well as correlations with the UPSIT scores. Results: Forty-eight COVID-19 patients were included in the study. Twenty-three were classified as olfactory dysfunction, and 25 as normal olfaction. The olfactory dysfunction group had lower GM volume in a cluster involving the left amygdala, insular cortex, parahippocampal gyrus, frontal superior and inferior orbital gyri, gyrus rectus, olfactory cortex, caudate, and putamen. This group also showed higher MD values in the genu of the corpus callosum, the orbitofrontal area, the anterior thalamic radiation, and the forceps minor; and higher RD values in the anterior corona radiata, the genu of the corpus callosum, and uncinate fasciculus compared with the normal olfaction group. The UPSIT scores for the whole sample were negatively associated with both MD and RD values (p-value ≤0.05 FWE-corrected). Interpretation: There is decreased GM volume and increased MD in olfactory-related regions explaining prolonged olfactory deficits in post-acute COVID-19 patients. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/191736 |
| url |
https://hdl.handle.net/2445/191736 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1002/acn3.51710 Annals of Clinical and Translational Neurology, 2022 https://doi.org/10.1002/acn3.51710 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd (c) Campabadal, Anna et al., 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by-nc-nd (c) Campabadal, Anna et al., 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
9 p. application/pdf |
| dc.publisher.none.fl_str_mv |
American Neurological Association |
| publisher.none.fl_str_mv |
American Neurological Association |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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