Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer

Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in pa...

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Detalles Bibliográficos
Autores: Saus, Ester, Brunet Vega, Anna, Iraola Guzmán, Susana, Pegueroles Queralt, Cinta, Gabaldón, Toni, Pericay, Carles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176571
Acceso en línea:https://hdl.handle.net/2445/176571
Access Level:acceso abierto
Palabra clave:Càncer colorectal
RNA
Marcadors bioquímics
Colorectal cancer
Biochemical markers
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spelling Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal CancerSaus, EsterBrunet Vega, AnnaIraola Guzmán, SusanaPegueroles Queralt, CintaGabaldón, ToniPericay, CarlesCàncer colorectalRNAMarcadors bioquímicsColorectal cancerRNABiochemical markersColorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression.Frontiers Media2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176571Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fgene.2016.00054Frontiers In Genetics, 2016, vol. 7, p. 54https://doi.org/10.3389/fgene.2016.00054info:eu-repo/grantAgreement/EC/H2020/642095info:eu-repo/grantAgreement/EC/FP7/310325cc-by (c) Saus, Ester et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1765712026-05-27T06:46:51Z
dc.title.none.fl_str_mv Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
title Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
spellingShingle Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
Saus, Ester
Càncer colorectal
RNA
Marcadors bioquímics
Colorectal cancer
RNA
Biochemical markers
title_short Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
title_full Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
title_fullStr Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
title_full_unstemmed Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
title_sort Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
dc.creator.none.fl_str_mv Saus, Ester
Brunet Vega, Anna
Iraola Guzmán, Susana
Pegueroles Queralt, Cinta
Gabaldón, Toni
Pericay, Carles
author Saus, Ester
author_facet Saus, Ester
Brunet Vega, Anna
Iraola Guzmán, Susana
Pegueroles Queralt, Cinta
Gabaldón, Toni
Pericay, Carles
author_role author
author2 Brunet Vega, Anna
Iraola Guzmán, Susana
Pegueroles Queralt, Cinta
Gabaldón, Toni
Pericay, Carles
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Càncer colorectal
RNA
Marcadors bioquímics
Colorectal cancer
RNA
Biochemical markers
topic Càncer colorectal
RNA
Marcadors bioquímics
Colorectal cancer
RNA
Biochemical markers
description Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176571
url https://hdl.handle.net/2445/176571
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fgene.2016.00054
Frontiers In Genetics, 2016, vol. 7, p. 54
https://doi.org/10.3389/fgene.2016.00054
info:eu-repo/grantAgreement/EC/H2020/642095
info:eu-repo/grantAgreement/EC/FP7/310325
dc.rights.none.fl_str_mv cc-by (c) Saus, Ester et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Saus, Ester et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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