Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis

Osteoarthritis is a source of chronic pain and disability. Dietary supplements have been shown to be a more secure option than NSAIDS. Particularly, the eggshell membrane has demonstrated efficacy in relieving joint pain and stiffness. A clinical trial was designed in which three groups were assigne...

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Autores: Cánovas García, Fernando, Abellán Ruiz, María Salud, García Muñoz, Ana María, Luque Rubia, Antonio J., Victoria Montesinos, Desirée, Pérez Piñero, Silvia, Sánchez Macarro, Maravillas, López Román, Francisco Javier
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Católica San Antonio de Murcia (UCAM)
Repositorio:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
OAI Identifier:oai:repositorio.ucam.edu:10952/8082
Acceso en línea:http://hdl.handle.net/10952/8082
Access Level:acceso abierto
Palabra clave:Knee pain
Dietary supplement
Stiffness
Glycosaminoglycans
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spelling Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritisCánovas García, FernandoAbellán Ruiz, María SaludGarcía Muñoz, Ana MaríaLuque Rubia, Antonio J.Victoria Montesinos, DesiréePérez Piñero, SilviaSánchez Macarro, MaravillasLópez Román, Francisco JavierKnee painDietary supplementStiffnessGlycosaminoglycansOsteoarthritis is a source of chronic pain and disability. Dietary supplements have been shown to be a more secure option than NSAIDS. Particularly, the eggshell membrane has demonstrated efficacy in relieving joint pain and stiffness. A clinical trial was designed in which three groups were assigned to two different doses of this supplement and compared to a placebo control group. The primary outcome variable was knee pain, which was assessed using a visual analogue scale. Secondary outcome variables were knee functional ability, quadriceps muscle strength (assessed by isometric and isokinetic trials), and quality of sleep. All groups showed a significant decrease in pain perception, although maximum values were obtained in the high-dose group. Isokinetic and isometric trials showed a significant increase in strength in the high-dose group. Eggshell membrane showed the potential to reduce pain and stiffness symptomatology. Here, for the first time, two quantitative variables (mobility and strength of knee joint) were used to accurately evaluate changes in the quality of life of subjects affected by knee joint pain. The results of this study indicate a dose-dependent response, which should be taken into account for later use in therapeutics to establish the correct dosage.Ciencias de la Alimentación2022info:eu-repo/semantics/articlehttp://hdl.handle.net/10952/8082reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murciainstname:Universidad Católica San Antonio de Murcia (UCAM)Inglésinfo:eu-repo/semantics/openAccessoai:repositorio.ucam.edu:10952/80822026-06-07T18:35:21Z
dc.title.none.fl_str_mv Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
title Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
spellingShingle Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
Cánovas García, Fernando
Knee pain
Dietary supplement
Stiffness
Glycosaminoglycans
title_short Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
title_full Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
title_fullStr Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
title_full_unstemmed Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
title_sort Randomised clinical trial to analyse the efficacy of eggshell membrane to improve joint functionality in knee osteoarthritis
dc.creator.none.fl_str_mv Cánovas García, Fernando
Abellán Ruiz, María Salud
García Muñoz, Ana María
Luque Rubia, Antonio J.
Victoria Montesinos, Desirée
Pérez Piñero, Silvia
Sánchez Macarro, Maravillas
López Román, Francisco Javier
author Cánovas García, Fernando
author_facet Cánovas García, Fernando
Abellán Ruiz, María Salud
García Muñoz, Ana María
Luque Rubia, Antonio J.
Victoria Montesinos, Desirée
Pérez Piñero, Silvia
Sánchez Macarro, Maravillas
López Román, Francisco Javier
author_role author
author2 Abellán Ruiz, María Salud
García Muñoz, Ana María
Luque Rubia, Antonio J.
Victoria Montesinos, Desirée
Pérez Piñero, Silvia
Sánchez Macarro, Maravillas
López Román, Francisco Javier
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Knee pain
Dietary supplement
Stiffness
Glycosaminoglycans
topic Knee pain
Dietary supplement
Stiffness
Glycosaminoglycans
description Osteoarthritis is a source of chronic pain and disability. Dietary supplements have been shown to be a more secure option than NSAIDS. Particularly, the eggshell membrane has demonstrated efficacy in relieving joint pain and stiffness. A clinical trial was designed in which three groups were assigned to two different doses of this supplement and compared to a placebo control group. The primary outcome variable was knee pain, which was assessed using a visual analogue scale. Secondary outcome variables were knee functional ability, quadriceps muscle strength (assessed by isometric and isokinetic trials), and quality of sleep. All groups showed a significant decrease in pain perception, although maximum values were obtained in the high-dose group. Isokinetic and isometric trials showed a significant increase in strength in the high-dose group. Eggshell membrane showed the potential to reduce pain and stiffness symptomatology. Here, for the first time, two quantitative variables (mobility and strength of knee joint) were used to accurately evaluate changes in the quality of life of subjects affected by knee joint pain. The results of this study indicate a dose-dependent response, which should be taken into account for later use in therapeutics to establish the correct dosage.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10952/8082
url http://hdl.handle.net/10952/8082
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
instname:Universidad Católica San Antonio de Murcia (UCAM)
instname_str Universidad Católica San Antonio de Murcia (UCAM)
reponame_str RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
collection RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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