Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches

Aging is a complex biological process characterized by a progressive decline in cellular and tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative potential, play a crucial role in maintaining tissue homeostasis and repair throughout an organism's lifespan...

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Detalhes bibliográficos
Autor: Mas-Bargues, Cristina
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:INCLIVA
Repositório:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17762
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/17762
Access Level:Acceso aberto
Palavra-chave:Mitochondria
Stem cells
Senescence
Aging
Anti -aging therapies
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spelling Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approachesMas-Bargues, CristinaMitochondriaStem cellsSenescenceAgingAnti -aging therapiesAging is a complex biological process characterized by a progressive decline in cellular and tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative potential, play a crucial role in maintaining tissue homeostasis and repair throughout an organism's lifespan. Mitochondria, the powerhouses of the cell, have emerged as key players in the aging process, impacting stem cell function and contributing to agerelated tissue dysfunction. Here are discuss the mechanisms through which mitochondria influence stem cell fate decisions, including energy production, metabolic regulation, ROS signalling, and epigenetic modifications. Therefore, this review highlights the role of mitochondria in driving stem cell senescence and the subsequent impact on tissue function, leading to overall organismal aging and age-related diseases. Finally, we explore potential anti-aging therapies targeting mitochondrial health and discuss their implications for promoting healthy aging. This comprehensive review sheds light on the critical interplay between mitochondrial function, stem cell senescence, and organismal aging, offering insights into potential strategies for attenuating age-related decline and promoting healthy longevity.ELSEVIER SCIENCE INC2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17762FREE RADICAL BIOLOGY AND MEDICINEISSN: 08915849ISSNe: 18734596reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p177622026-06-07T16:35:31Z
dc.title.none.fl_str_mv Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
title Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
spellingShingle Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Mas-Bargues, Cristina
Mitochondria
Stem cells
Senescence
Aging
Anti -aging therapies
title_short Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
title_full Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
title_fullStr Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
title_full_unstemmed Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
title_sort Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
dc.creator.none.fl_str_mv Mas-Bargues, Cristina
author Mas-Bargues, Cristina
author_facet Mas-Bargues, Cristina
author_role author
dc.subject.none.fl_str_mv Mitochondria
Stem cells
Senescence
Aging
Anti -aging therapies
topic Mitochondria
Stem cells
Senescence
Aging
Anti -aging therapies
description Aging is a complex biological process characterized by a progressive decline in cellular and tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative potential, play a crucial role in maintaining tissue homeostasis and repair throughout an organism's lifespan. Mitochondria, the powerhouses of the cell, have emerged as key players in the aging process, impacting stem cell function and contributing to agerelated tissue dysfunction. Here are discuss the mechanisms through which mitochondria influence stem cell fate decisions, including energy production, metabolic regulation, ROS signalling, and epigenetic modifications. Therefore, this review highlights the role of mitochondria in driving stem cell senescence and the subsequent impact on tissue function, leading to overall organismal aging and age-related diseases. Finally, we explore potential anti-aging therapies targeting mitochondrial health and discuss their implications for promoting healthy aging. This comprehensive review sheds light on the critical interplay between mitochondrial function, stem cell senescence, and organismal aging, offering insights into potential strategies for attenuating age-related decline and promoting healthy longevity.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/17762
url https://incliva.portalinvestigacion.com/publicaciones/17762
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv FREE RADICAL BIOLOGY AND MEDICINE
ISSN: 08915849
ISSNe: 18734596
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
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