The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:306311 |
| Acesso em linha: | https://ddd.uab.cat/record/306311 https://dx.doi.org/urn:doi:10.1186/s12979-024-00435-2 |
| Access Level: | acceso abierto |
| Palavra-chave: | Alzheimer's disease Amyloid-β CSF NLR Neutrophil to lymphocyte ratio P-tau T-tau |
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The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly peopleJacobs, ToviaJacobson, Sean R.Fortea, Juan|||0000-0002-1340-638XBerger, Jeffrey S.Vedvyas, AlokMarsh, KarynHe, TiansheGutierrez-Jimenez, EugenioFillmore, Nathanael R.Gonzalez, MosesFigueredo, LuisaGaggi, Naomi L.Plaska, Chelsea ReichertPomara, NunzioBlessing, EstherBetensky, RebeccaRusinek, HenryZetterberg, Henrik|||0000-0003-3930-4354Blennow, Kaj|||0000-0002-1890-4193Glodzik, LidiaWisniweski, Thomas M.de Leon, Mony J.Osorio, Ricardo S.Ramos-Cejudo, JaimeAlzheimer's diseaseAmyloid-βCSFNLRNeutrophil to lymphocyte ratioP-tauT-tauAn elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects. Adjusting for sociodemographics, APOE4, and common comorbidities, we investigated these associations in two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the M.J. de Leon CSF repository at NYU. Specifically, we examined associations between the NLR and cross-sectional measures of amyloid-β42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau), as well as the trajectories of these CSF measures obtained longitudinally. A total of 111 ADNI and 190 NYU participants classified as CU with available NLR, CSF, and covariate data were included. Compared to NYU, ADNI participants were older (73.79 vs. 61.53, p < 0.001), had a higher proportion of males (49.5% vs. 36.8%, p = 0.042), higher BMIs (27.94 vs. 25.79, p < 0.001), higher prevalence of hypertensive history (47.7% vs. 16.3%, p < 0.001), and a greater percentage of Aβ-positivity (34.2% vs. 20.0%, p = 0.009). In the ADNI cohort, we found cross-sectional associations between the NLR and CSF Aβ42 (β = -12.193, p = 0.021), but not t-tau or p-tau. In the NYU cohort, we found cross-sectional associations between the NLR and CSF t-tau (β = 26.812, p = 0.019) and p-tau (β = 3.441, p = 0.015), but not Aβ42. In the NYU cohort alone, subjects classified as Aβ + (n = 38) displayed a stronger association between the NLR and t-tau (β = 100.476, p = 0.037) compared to Aβ- subjects or the non-stratified cohort. In both cohorts, the same associations observed in the cross-sectional analyses were observed after incorporating longitudinal CSF data. We report associations between the NLR and Aβ42 in the older ADNI cohort, and between the NLR and t-tau and p-tau in the younger NYU cohort. Associations persisted after adjusting for comorbidities, suggesting a direct link between the NLR and AD. However, changes in associations between the NLR and specific AD biomarkers may occur as part of immunosenescence.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/306311https://dx.doi.org/urn:doi:10.1186/s12979-024-00435-2reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3063112026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people |
| title |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people |
| spellingShingle |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people Jacobs, Tovia Alzheimer's disease Amyloid-β CSF NLR Neutrophil to lymphocyte ratio P-tau T-tau |
| title_short |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people |
| title_full |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people |
| title_fullStr |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people |
| title_full_unstemmed |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people |
| title_sort |
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people |
| dc.creator.none.fl_str_mv |
Jacobs, Tovia Jacobson, Sean R. Fortea, Juan|||0000-0002-1340-638X Berger, Jeffrey S. Vedvyas, Alok Marsh, Karyn He, Tianshe Gutierrez-Jimenez, Eugenio Fillmore, Nathanael R. Gonzalez, Moses Figueredo, Luisa Gaggi, Naomi L. Plaska, Chelsea Reichert Pomara, Nunzio Blessing, Esther Betensky, Rebecca Rusinek, Henry Zetterberg, Henrik|||0000-0003-3930-4354 Blennow, Kaj|||0000-0002-1890-4193 Glodzik, Lidia Wisniweski, Thomas M. de Leon, Mony J. Osorio, Ricardo S. Ramos-Cejudo, Jaime |
| author |
Jacobs, Tovia |
| author_facet |
Jacobs, Tovia Jacobson, Sean R. Fortea, Juan|||0000-0002-1340-638X Berger, Jeffrey S. Vedvyas, Alok Marsh, Karyn He, Tianshe Gutierrez-Jimenez, Eugenio Fillmore, Nathanael R. Gonzalez, Moses Figueredo, Luisa Gaggi, Naomi L. Plaska, Chelsea Reichert Pomara, Nunzio Blessing, Esther Betensky, Rebecca Rusinek, Henry Zetterberg, Henrik|||0000-0003-3930-4354 Blennow, Kaj|||0000-0002-1890-4193 Glodzik, Lidia Wisniweski, Thomas M. de Leon, Mony J. Osorio, Ricardo S. Ramos-Cejudo, Jaime |
| author_role |
author |
| author2 |
Jacobson, Sean R. Fortea, Juan|||0000-0002-1340-638X Berger, Jeffrey S. Vedvyas, Alok Marsh, Karyn He, Tianshe Gutierrez-Jimenez, Eugenio Fillmore, Nathanael R. Gonzalez, Moses Figueredo, Luisa Gaggi, Naomi L. Plaska, Chelsea Reichert Pomara, Nunzio Blessing, Esther Betensky, Rebecca Rusinek, Henry Zetterberg, Henrik|||0000-0003-3930-4354 Blennow, Kaj|||0000-0002-1890-4193 Glodzik, Lidia Wisniweski, Thomas M. de Leon, Mony J. Osorio, Ricardo S. Ramos-Cejudo, Jaime |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Alzheimer's disease Amyloid-β CSF NLR Neutrophil to lymphocyte ratio P-tau T-tau |
| topic |
Alzheimer's disease Amyloid-β CSF NLR Neutrophil to lymphocyte ratio P-tau T-tau |
| description |
An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects. Adjusting for sociodemographics, APOE4, and common comorbidities, we investigated these associations in two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the M.J. de Leon CSF repository at NYU. Specifically, we examined associations between the NLR and cross-sectional measures of amyloid-β42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau), as well as the trajectories of these CSF measures obtained longitudinally. A total of 111 ADNI and 190 NYU participants classified as CU with available NLR, CSF, and covariate data were included. Compared to NYU, ADNI participants were older (73.79 vs. 61.53, p < 0.001), had a higher proportion of males (49.5% vs. 36.8%, p = 0.042), higher BMIs (27.94 vs. 25.79, p < 0.001), higher prevalence of hypertensive history (47.7% vs. 16.3%, p < 0.001), and a greater percentage of Aβ-positivity (34.2% vs. 20.0%, p = 0.009). In the ADNI cohort, we found cross-sectional associations between the NLR and CSF Aβ42 (β = -12.193, p = 0.021), but not t-tau or p-tau. In the NYU cohort, we found cross-sectional associations between the NLR and CSF t-tau (β = 26.812, p = 0.019) and p-tau (β = 3.441, p = 0.015), but not Aβ42. In the NYU cohort alone, subjects classified as Aβ + (n = 38) displayed a stronger association between the NLR and t-tau (β = 100.476, p = 0.037) compared to Aβ- subjects or the non-stratified cohort. In both cohorts, the same associations observed in the cross-sectional analyses were observed after incorporating longitudinal CSF data. We report associations between the NLR and Aβ42 in the older ADNI cohort, and between the NLR and t-tau and p-tau in the younger NYU cohort. Associations persisted after adjusting for comorbidities, suggesting a direct link between the NLR and AD. However, changes in associations between the NLR and specific AD biomarkers may occur as part of immunosenescence. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/306311 https://dx.doi.org/urn:doi:10.1186/s12979-024-00435-2 |
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https://ddd.uab.cat/record/306311 https://dx.doi.org/urn:doi:10.1186/s12979-024-00435-2 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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