Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals

Research on the neural imprint of dual-language experience, crucial for understanding how the brain processes dominant and non-dominant languages, remains inconclusive. Conflicting evidence suggests either similarity or distinction in neural processing, with implications for bilingual patients with...

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Autores: Quiñones, Ileana, Gisbert Muñoz, Sandra, Amoruso, Lucía, Manso Ortega, Lucía, Mori Carrascal, Usue, Bermúdez, Garazi, Gil Robles, Santiago, Pomposo Gastelu, Iñigo Cristobal, Carreiras, Manuel
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/70979
Acceso en línea:http://hdl.handle.net/10810/70979
Access Level:acceso abierto
Palabra clave:bilingualism
speech production
neuroplasticity
brain tumors
fMRI
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repository_id_str
dc.title.none.fl_str_mv Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
title Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
spellingShingle Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
Quiñones, Ileana
bilingualism
speech production
neuroplasticity
brain tumors
fMRI
title_short Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
title_full Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
title_fullStr Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
title_full_unstemmed Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
title_sort Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
dc.creator.none.fl_str_mv Quiñones, Ileana
Gisbert Muñoz, Sandra
Amoruso, Lucía
Manso Ortega, Lucía
Mori Carrascal, Usue
Bermúdez, Garazi
Gil Robles, Santiago
Pomposo Gastelu, Iñigo Cristobal
Carreiras, Manuel
author Quiñones, Ileana
author_facet Quiñones, Ileana
Gisbert Muñoz, Sandra
Amoruso, Lucía
Manso Ortega, Lucía
Mori Carrascal, Usue
Bermúdez, Garazi
Gil Robles, Santiago
Pomposo Gastelu, Iñigo Cristobal
Carreiras, Manuel
author_role author
author2 Gisbert Muñoz, Sandra
Amoruso, Lucía
Manso Ortega, Lucía
Mori Carrascal, Usue
Bermúdez, Garazi
Gil Robles, Santiago
Pomposo Gastelu, Iñigo Cristobal
Carreiras, Manuel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv bilingualism
speech production
neuroplasticity
brain tumors
fMRI
topic bilingualism
speech production
neuroplasticity
brain tumors
fMRI
description Research on the neural imprint of dual-language experience, crucial for understanding how the brain processes dominant and non-dominant languages, remains inconclusive. Conflicting evidence suggests either similarity or distinction in neural processing, with implications for bilingual patients with brain tumors. Preserving dual-language functions after surgery requires considering pre-diagnosis neuroplastic changes. Here, we combine univariate and multivariate fMRI methodologies to test a group of healthy Spanish-Basque bilinguals and a group of bilingual patients with gliomas affecting the language-dominant hemisphere while they overtly produced sentences in either their dominant or non-dominant language. Findings from healthy participants revealed the presence of a shared neural system for both languages, while also identifying regions with distinct language-dependent activation and lateralization patterns. Specifically, while the dominant language engaged a more left-lateralized network, speech production in the non-dominant language relied on the recruitment of a bilateral basal ganglia-thalamo-cortical circuit. Notably, based on language lateralization patterns, we were able to robustly decode (AUC: 0.80 ± 0.18) the language being used. Conversely, bilingual patients exhibited bilateral activation patterns for both languages. For the dominant language, regions such as the cerebellum, thalamus, and caudate acted in concert with the sparsely activated language-specific nodes. In the case of the non-dominant language, the recruitment of the default mode network was notably prominent. These results demonstrate the compensatory engagement of non-language-specific networks in the preservation of bilingual speech production, even in the face of pathological conditions. Overall, our findings underscore the pervasive impact of dual-language experience on brain functional (re)organization, both in health and disease.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/70979
url http://hdl.handle.net/10810/70979
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/CEX2020-001010-S/
info:eu-repo/grantAgreement/MICINN/RYC2022-035514-I/
info:eu-repo/grantAgreement/MICIU/RTI2018-093547-B-I00/
https://link.springer.com/article/10.1007/s00429-024-02846-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
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spelling Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individualsQuiñones, IleanaGisbert Muñoz, SandraAmoruso, LucíaManso Ortega, LucíaMori Carrascal, UsueBermúdez, GaraziGil Robles, SantiagoPomposo Gastelu, Iñigo CristobalCarreiras, Manuelbilingualismspeech productionneuroplasticitybrain tumorsfMRIResearch on the neural imprint of dual-language experience, crucial for understanding how the brain processes dominant and non-dominant languages, remains inconclusive. Conflicting evidence suggests either similarity or distinction in neural processing, with implications for bilingual patients with brain tumors. Preserving dual-language functions after surgery requires considering pre-diagnosis neuroplastic changes. Here, we combine univariate and multivariate fMRI methodologies to test a group of healthy Spanish-Basque bilinguals and a group of bilingual patients with gliomas affecting the language-dominant hemisphere while they overtly produced sentences in either their dominant or non-dominant language. Findings from healthy participants revealed the presence of a shared neural system for both languages, while also identifying regions with distinct language-dependent activation and lateralization patterns. Specifically, while the dominant language engaged a more left-lateralized network, speech production in the non-dominant language relied on the recruitment of a bilateral basal ganglia-thalamo-cortical circuit. Notably, based on language lateralization patterns, we were able to robustly decode (AUC: 0.80 ± 0.18) the language being used. Conversely, bilingual patients exhibited bilateral activation patterns for both languages. For the dominant language, regions such as the cerebellum, thalamus, and caudate acted in concert with the sparsely activated language-specific nodes. In the case of the non-dominant language, the recruitment of the default mode network was notably prominent. These results demonstrate the compensatory engagement of non-language-specific networks in the preservation of bilingual speech production, even in the face of pathological conditions. Overall, our findings underscore the pervasive impact of dual-language experience on brain functional (re)organization, both in health and disease.This research was supported by the Basque Government through the BERC 2022-2025 program and by the Spanish State Research Agency through BCBL Severo Ochoa excellence accreditation CEX2020-001010-S, the Ramon y Cajal Fellowships RYC2022-035514-I (LA), and RYC2022-035533-I (IQ), and by the Spanish Ministry of Science and Education through project RTI2018-093547-B-I00. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.Springer Nature202420242024info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/70979reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/CEX2020-001010-S/info:eu-repo/grantAgreement/MICINN/RYC2022-035514-I/info:eu-repo/grantAgreement/MICIU/RTI2018-093547-B-I00/https://link.springer.com/article/10.1007/s00429-024-02846-9info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Atribución 3.0 Españaoai:addi.ehu.eus:10810/709792026-06-18T09:23:17Z
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