International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors

[EN] Circulating tumor DNA (ctDNA) testing has transformed precision oncology by enabling the non-invasive detection of actionable mutations. To facilitate broader clinical adoption and improve testing accuracy, standardized quality criteria must be clearly defined and universally implemented. The I...

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Autores: Fusco, Nicola, Venetis, Konstantinos, Pepe, Francesco, Shetty, Omshree, Farinas, Silvia Calabuig, Heeke, Simon, Burnier, Julia V., Patton, Simon J., Heitzer, Ellen, Nigita, Giovanni, Hofman, Paul, Serrano, Maria Jose, Cristofanilli, Massimo, Gandara, David R., Jantus-Lewintre, Eloisa|||0000-0001-7395-4380
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/226115
Acceso en línea:https://riunet.upv.es/handle/10251/226115
Access Level:acceso abierto
Palabra clave:Circulating tumor DNA (ctDNA)
Precision oncology
Standardization
Quality assurance
Liquid biopsy
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spelling International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumorsFusco, NicolaVenetis, KonstantinosPepe, FrancescoShetty, OmshreeFarinas, Silvia CalabuigHeeke, SimonBurnier, Julia V.Patton, Simon J.Heitzer, EllenNigita, GiovanniHofman, PaulSerrano, Maria JoseCristofanilli, MassimoGandara, David R.Jantus-Lewintre, Eloisa|||0000-0001-7395-4380Circulating tumor DNA (ctDNA)Precision oncologyStandardizationQuality assuranceLiquid biopsy[EN] Circulating tumor DNA (ctDNA) testing has transformed precision oncology by enabling the non-invasive detection of actionable mutations. To facilitate broader clinical adoption and improve testing accuracy, standardized quality criteria must be clearly defined and universally implemented. The International Society of Liquid Biopsy (ISLB) established the Quality Control and Accreditation Committee to develop consensus-based minimal standards for ctDNA analysis in oncology. Ensuring reliable and reproducible ctDNA testing necessitates standardization across the pre-analytical, analytical, and post-analytical phases. Key considerations include appropriate blood collection, efficient cfDNA isolation and purification, thorough assay validation, and precise data interpretation. The ISLB is committed to leading collaborative efforts among laboratories, regulatory bodies, and professional organizations to advance standardization and ensure high-quality ctDNA testing worldwide. Through initiatives led by the Quality Control and Accreditation Committee, educational programs, and multidisciplinary stakeholder workshops, ISLB provides a structured framework to promote standardization and foster innovation. By addressing current challenges and advocating for robust quality standards, ctDNA testing can reach its full potential in advancing personalized cancer care, enabling more precise and timely interventions for patients. This manuscript provides the first global initiative for quality control in liquid biopsy, presenting the ISLB perspective on minimal requirements for ctDNA testing in solid tumors.Elsevier B.V.Departamento de BiotecnologíaCentro Avanzado de Microbiología AplicadaEscuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalInstituto de Salud Carlos IIIRepositorio Institucional de la Universitat Politècnica de València Riunet20252025-06-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/226115reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2261152026-06-13T07:49:27Z
dc.title.none.fl_str_mv International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
title International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
spellingShingle International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
Fusco, Nicola
Circulating tumor DNA (ctDNA)
Precision oncology
Standardization
Quality assurance
Liquid biopsy
title_short International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
title_full International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
title_fullStr International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
title_full_unstemmed International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
title_sort International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
dc.creator.none.fl_str_mv Fusco, Nicola
Venetis, Konstantinos
Pepe, Francesco
Shetty, Omshree
Farinas, Silvia Calabuig
Heeke, Simon
Burnier, Julia V.
Patton, Simon J.
Heitzer, Ellen
Nigita, Giovanni
Hofman, Paul
Serrano, Maria Jose
Cristofanilli, Massimo
Gandara, David R.
Jantus-Lewintre, Eloisa|||0000-0001-7395-4380
author Fusco, Nicola
author_facet Fusco, Nicola
Venetis, Konstantinos
Pepe, Francesco
Shetty, Omshree
Farinas, Silvia Calabuig
Heeke, Simon
Burnier, Julia V.
Patton, Simon J.
Heitzer, Ellen
Nigita, Giovanni
Hofman, Paul
Serrano, Maria Jose
Cristofanilli, Massimo
Gandara, David R.
Jantus-Lewintre, Eloisa|||0000-0001-7395-4380
author_role author
author2 Venetis, Konstantinos
Pepe, Francesco
Shetty, Omshree
Farinas, Silvia Calabuig
Heeke, Simon
Burnier, Julia V.
Patton, Simon J.
Heitzer, Ellen
Nigita, Giovanni
Hofman, Paul
Serrano, Maria Jose
Cristofanilli, Massimo
Gandara, David R.
Jantus-Lewintre, Eloisa|||0000-0001-7395-4380
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biotecnología
Centro Avanzado de Microbiología Aplicada
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
Instituto de Salud Carlos III
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Circulating tumor DNA (ctDNA)
Precision oncology
Standardization
Quality assurance
Liquid biopsy
topic Circulating tumor DNA (ctDNA)
Precision oncology
Standardization
Quality assurance
Liquid biopsy
description [EN] Circulating tumor DNA (ctDNA) testing has transformed precision oncology by enabling the non-invasive detection of actionable mutations. To facilitate broader clinical adoption and improve testing accuracy, standardized quality criteria must be clearly defined and universally implemented. The International Society of Liquid Biopsy (ISLB) established the Quality Control and Accreditation Committee to develop consensus-based minimal standards for ctDNA analysis in oncology. Ensuring reliable and reproducible ctDNA testing necessitates standardization across the pre-analytical, analytical, and post-analytical phases. Key considerations include appropriate blood collection, efficient cfDNA isolation and purification, thorough assay validation, and precise data interpretation. The ISLB is committed to leading collaborative efforts among laboratories, regulatory bodies, and professional organizations to advance standardization and ensure high-quality ctDNA testing worldwide. Through initiatives led by the Quality Control and Accreditation Committee, educational programs, and multidisciplinary stakeholder workshops, ISLB provides a structured framework to promote standardization and foster innovation. By addressing current challenges and advocating for robust quality standards, ctDNA testing can reach its full potential in advancing personalized cancer care, enabling more precise and timely interventions for patients. This manuscript provides the first global initiative for quality control in liquid biopsy, presenting the ISLB perspective on minimal requirements for ctDNA testing in solid tumors.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-06-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/226115
url https://riunet.upv.es/handle/10251/226115
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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