Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

[Background]: Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut...

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Autores: Mayneris-Perxachs, Jordi, Arnoriaga-Rodríguez, María, Luque-Córdoba, Diego, Priego-Capote, Feliciano, Pérez-Brocal, Vicente, Moya, Andrés, Burokas, Aurelijus, Maldonado, Rafael, Fernández-Real, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/247269
Acceso en línea:http://hdl.handle.net/10261/247269
Access Level:acceso abierto
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
title Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
spellingShingle Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
Mayneris-Perxachs, Jordi
title_short Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
title_full Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
title_fullStr Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
title_full_unstemmed Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
title_sort Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
dc.creator.none.fl_str_mv Mayneris-Perxachs, Jordi
Arnoriaga-Rodríguez, María
Luque-Córdoba, Diego
Priego-Capote, Feliciano
Pérez-Brocal, Vicente
Moya, Andrés
Burokas, Aurelijus
Maldonado, Rafael
Fernández-Real, José Manuel
author Mayneris-Perxachs, Jordi
author_facet Mayneris-Perxachs, Jordi
Arnoriaga-Rodríguez, María
Luque-Córdoba, Diego
Priego-Capote, Feliciano
Pérez-Brocal, Vicente
Moya, Andrés
Burokas, Aurelijus
Maldonado, Rafael
Fernández-Real, José Manuel
author_role author
author2 Arnoriaga-Rodríguez, María
Luque-Córdoba, Diego
Priego-Capote, Feliciano
Pérez-Brocal, Vicente
Moya, Andrés
Burokas, Aurelijus
Maldonado, Rafael
Fernández-Real, José Manuel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Generalitat Valenciana
Generalitat de Catalunya
European Commission
Research Council of Lithuania
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description [Background]: Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut microbiota and the potential role of the microbiome in influencing sex steroid hormones and shaping sexually dimorphic susceptibility to disease have been largely overlooked. Although there is some evidence of sex-specific differences in the gut microbiota diversity, composition, and functionality, the results are inconsistent. Importantly, most of these studies have not taken into account the gonadal steroid status. Therefore, we investigated the gut microbiome composition and functionality in relation to sex, menopausal status, and circulating sex steroids.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/247269
url http://hdl.handle.net/10261/247269
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-65878-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-84060-R
SAF2017-84060-R/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/EC/FP7/602891
info:eu-repo/grantAgreement/EC/H2020/848099
https://doi.org/10.1186/s40168-020-00913-x
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal statusMayneris-Perxachs, JordiArnoriaga-Rodríguez, MaríaLuque-Córdoba, DiegoPriego-Capote, FelicianoPérez-Brocal, VicenteMoya, AndrésBurokas, AurelijusMaldonado, RafaelFernández-Real, José Manuel[Background]: Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut microbiota and the potential role of the microbiome in influencing sex steroid hormones and shaping sexually dimorphic susceptibility to disease have been largely overlooked. Although there is some evidence of sex-specific differences in the gut microbiota diversity, composition, and functionality, the results are inconsistent. Importantly, most of these studies have not taken into account the gonadal steroid status. Therefore, we investigated the gut microbiome composition and functionality in relation to sex, menopausal status, and circulating sex steroids.[Results]: No significant differences were found in alpha diversity indices among pre- and post-menopausal women and men, but beta diversity differed among groups. The gut microbiota from post-menopausal women was more similar to men than to pre-menopausal women. Metagenome functional analyses revealed no significant differences between post-menopausal women and men. Gonadal steroids were specifically associated with these differences. Hence, the gut microbiota of pre-menopausal women was more enriched in genes from the steroid biosynthesis and degradation pathways, with the former having the strongest fold change among all associated pathways. Microbial steroid pathways also had significant associations with the plasma levels of testosterone and progesterone. In addition, a specific microbiome signature was able to predict the circulating testosterone levels at baseline and after 1-year follow-up. In addition, this microbiome signature could be transmitted from humans to antibiotic-induced microbiome-depleted male mice, being able to predict donor’s testosterone levels 4 weeks later, implying that the microbiota profile of the recipient mouse was influenced by the donor’s gender. Finally, obesity eliminated most of the differences observed among non-obese pre-menopausal women, post-menopausal women, and men in the gut microbiota composition (Bray-Curtis and weighted unifrac beta diversity), functionality, and the gonadal steroid status.[Conclusions]: The present findings evidence clear differences in the gut microbial composition and functionality between men and women, which is eliminated by both menopausal and obesity status. We also reveal a tight link between the gut microbiota composition and the circulating levels of gonadal steroids, particularly testosterone.This work was partially supported by research grants FIS (PI15/01934) from the Instituto de Salud Carlos III from Spain, SAF2015-65878-R and AEI-SAF2017-84060-R from Ministry of Economy and Competitiveness, Prometeo/2018/A/133 from Generalitat Valenciana, Spain, and also by European Commission (FP7, NeuroPain #2013-602891; #H2020-SC1-2019-2-RTD-848099 (PAINFACT)), the Catalan Government (AGAUR, #SGR2017-669, ICREA Academia Award 2015), the Spanish Instituto de Salud Carlos III (RTA, #RD16/0017/0020), the Fondo Europeo de Desarrollo Regional (FEDER) through the Programa Interreg V-A España-Francia-Andorra (POCTEFA 2014-2020), and the European Regional Development Fund (project No. 01.2.2-LMT-K-718-02-0014) under grant agreement with the Research Council of Lithuania (LMTLT). María Arnoriaga Rodríguez is funded by a predoctoral Río Hortega contract (CM19/00190, co-funded by European Social Fund “Investing in your future”) from the Instituto de Salud Carlos III, Spain. Jordi Mayneris-Perxachs is funded by the Miguel Servet Program from the Instituto de Salud Carlos III (ISCIII CP18/00009), co-funded by the European Social Fund “Investing in your future”.Peer reviewedBioMed CentralInstituto de Salud Carlos IIIMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Generalitat ValencianaGeneralitat de CatalunyaEuropean CommissionResearch Council of LithuaniaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/247269reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-65878-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-84060-RSAF2017-84060-R/AEI/10.13039/501100011033info:eu-repo/grantAgreement/EC/FP7/602891info:eu-repo/grantAgreement/EC/H2020/848099https://doi.org/10.1186/s40168-020-00913-xSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2472692026-05-22T06:33:51Z
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