Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.

For successful regeneration, the identity of the missing tissue must be specified according to the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this process; the same field of cells can regrow a head or a tail according to the missing body part. After amputati...

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Autores: Pascual-Carreras, Eudald, Marín-Barba, Marta, Castillo-Lara, Sergio, Coronel-Córdoba, Pablo, Magri Sílvia, Marta, Wheeler, Grant N., Gómez-Skarmeta, José Luis, Abril Ferrando, Josep Francesc, 1970-, Saló i Boix, Emili, Adell i Creixell, Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192761
Acceso en línea:https://hdl.handle.net/2445/192761
Access Level:acceso abierto
Palabra clave:Planària (Gènere)
Cèl·lules
Cromatina
Amputació
Genòmica
Planaria (Genus)
Cells
Chromatin
Amputation
Genomics
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network_name_str España
repository_id_str
spelling Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.Pascual-Carreras, EudaldMarín-Barba, MartaCastillo-Lara, SergioCoronel-Córdoba, PabloMagri Sílvia, MartaWheeler, Grant N.Gómez-Skarmeta, José LuisAbril Ferrando, Josep Francesc, 1970-Saló i Boix, EmiliAdell i Creixell, TeresaPlanària (Gènere)Cèl·lulesCromatinaAmputacióGenòmicaPlanaria (Genus)CellsChromatinAmputationGenomicsFor successful regeneration, the identity of the missing tissue must be specified according to the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this process; the same field of cells can regrow a head or a tail according to the missing body part. After amputation, the differential activation of the Wnt/β-catenin signal specifies anterior versus posterior identity. Initially, both wnt1 and notum (Wnt inhibitor) are expressed in all wounds, but 48 hours later they are restricted to posterior or anterior facing wounds, respectively, by an unknown mechanism. Here we show that 12 hours after amputation, the chromatin accessibility of cells in the wound region changes according to the polarity of the pre-existing tissue in a Wnt/β-catenin-dependent manner. Genomic analyses suggest that homeobox transcription factors and chromatin-remodeling proteins are direct Wnt/β-catenin targets, which trigger the expression of posterior effectors. Finally, we identify FoxG as a wnt1 up-stream regulator, probably via binding to its first intron enhancer region.Nature Publishing Group2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/192761Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41467-023-35937-yNature Communications, 2023, vol. 14, num. 298, p. 1-16https://doi.org/10.1038/s41467-023-35937-ycc-by (c) Pascual-Carreras, Eudald et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1927612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
title Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
spellingShingle Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
Pascual-Carreras, Eudald
Planària (Gènere)
Cèl·lules
Cromatina
Amputació
Genòmica
Planaria (Genus)
Cells
Chromatin
Amputation
Genomics
title_short Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
title_full Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
title_fullStr Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
title_full_unstemmed Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
title_sort Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.
dc.creator.none.fl_str_mv Pascual-Carreras, Eudald
Marín-Barba, Marta
Castillo-Lara, Sergio
Coronel-Córdoba, Pablo
Magri Sílvia, Marta
Wheeler, Grant N.
Gómez-Skarmeta, José Luis
Abril Ferrando, Josep Francesc, 1970-
Saló i Boix, Emili
Adell i Creixell, Teresa
author Pascual-Carreras, Eudald
author_facet Pascual-Carreras, Eudald
Marín-Barba, Marta
Castillo-Lara, Sergio
Coronel-Córdoba, Pablo
Magri Sílvia, Marta
Wheeler, Grant N.
Gómez-Skarmeta, José Luis
Abril Ferrando, Josep Francesc, 1970-
Saló i Boix, Emili
Adell i Creixell, Teresa
author_role author
author2 Marín-Barba, Marta
Castillo-Lara, Sergio
Coronel-Córdoba, Pablo
Magri Sílvia, Marta
Wheeler, Grant N.
Gómez-Skarmeta, José Luis
Abril Ferrando, Josep Francesc, 1970-
Saló i Boix, Emili
Adell i Creixell, Teresa
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Planària (Gènere)
Cèl·lules
Cromatina
Amputació
Genòmica
Planaria (Genus)
Cells
Chromatin
Amputation
Genomics
topic Planària (Gènere)
Cèl·lules
Cromatina
Amputació
Genòmica
Planaria (Genus)
Cells
Chromatin
Amputation
Genomics
description For successful regeneration, the identity of the missing tissue must be specified according to the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this process; the same field of cells can regrow a head or a tail according to the missing body part. After amputation, the differential activation of the Wnt/β-catenin signal specifies anterior versus posterior identity. Initially, both wnt1 and notum (Wnt inhibitor) are expressed in all wounds, but 48 hours later they are restricted to posterior or anterior facing wounds, respectively, by an unknown mechanism. Here we show that 12 hours after amputation, the chromatin accessibility of cells in the wound region changes according to the polarity of the pre-existing tissue in a Wnt/β-catenin-dependent manner. Genomic analyses suggest that homeobox transcription factors and chromatin-remodeling proteins are direct Wnt/β-catenin targets, which trigger the expression of posterior effectors. Finally, we identify FoxG as a wnt1 up-stream regulator, probably via binding to its first intron enhancer region.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192761
url https://hdl.handle.net/2445/192761
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41467-023-35937-y
Nature Communications, 2023, vol. 14, num. 298, p. 1-16
https://doi.org/10.1038/s41467-023-35937-y
dc.rights.none.fl_str_mv cc-by (c) Pascual-Carreras, Eudald et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Pascual-Carreras, Eudald et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418137136398336
score 15.81155

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