Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study

[Aims]: The relationship between iron status, obesity and type 2 diabetes mellitus (T2DM) has scarcely been tested. This study hypothesizes that patients with obesity and T2DM have altered iron metabolism.

Detalles Bibliográficos
Autores: Vaquero, M. Pilar, Martínez-Suárez, Miriam, García-Quismondo, Ángel, Cañizo, F. J. del, Sánchez-Muniz, F. J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/241381
Acceso en línea:http://hdl.handle.net/10261/241381
Access Level:acceso abierto
Palabra clave:Diabesity, Inflammation, Iron status, Transferrin saturation, Waist perimeter, Type 2 diabetes
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spelling Diabesity negatively affects transferrin saturation and iron status. The DICARIVA studyVaquero, M. PilarMartínez-Suárez, MiriamGarcía-Quismondo, ÁngelCañizo, F. J. delSánchez-Muniz, F. J.Diabesity, Inflammation, Iron status, Transferrin saturation, Waist perimeter, Type 2 diabetes[Aims]: The relationship between iron status, obesity and type 2 diabetes mellitus (T2DM) has scarcely been tested. This study hypothesizes that patients with obesity and T2DM have altered iron metabolism.[Methods]: 537 T2DM patients were selected from the cross-sectional DICARIVA study excluding patients with high-sensitivity-C-reactive-protein (hs-CRP) ≥ 10 mg/L. Three groups according to body mass index (BMI) and waist perimeter (WP) were analysed: a) BMI < 30 kg/m2, non-high WP (n = 105); b) BMI < 30 kg/m2, high WP (n = 202); and c) diabesity, BMI ≥ 30 kg/m2, high WP (n = 230). Group differences on cardiometabolic and iron status markers were tested.[Results]: Women had significantly lower iron, ferritin, and transferrin saturation (TSAT) but higher transferrin and total iron binding capacity than men. Triglycerides/HDL-c ratio, as insulin-resistance (IR) marker, was higher in men while hs-CRP in women. TSAT was inversely related to BMI and hs-CRP. The diabesity group showed the highest hs-CRP (p < 0.001) and IR (p < 0.001) with the lowest TSAT (p = 0.003).[Conclusions]: Low TSAT was highly prevalent in diabesity, mainly in women, suggesting that IR, inflammation, and abdominal adiposity alter iron transport and accumulation. The convenience of iron supplementation in diabesity patients with low TSAT should be urgently assessed, due the pro-oxidant effects of excess iron.This article was partially granted by the PID2019-103872RB-I00 Spanish project.Peer reviewedElsevierMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/241381reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103872RB-I00https://doi.org/10.1016/j.diabres.2021.108653Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2413812026-05-22T06:33:51Z
dc.title.none.fl_str_mv Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
title Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
spellingShingle Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
Vaquero, M. Pilar
Diabesity, Inflammation, Iron status, Transferrin saturation, Waist perimeter, Type 2 diabetes
title_short Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
title_full Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
title_fullStr Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
title_full_unstemmed Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
title_sort Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study
dc.creator.none.fl_str_mv Vaquero, M. Pilar
Martínez-Suárez, Miriam
García-Quismondo, Ángel
Cañizo, F. J. del
Sánchez-Muniz, F. J.
author Vaquero, M. Pilar
author_facet Vaquero, M. Pilar
Martínez-Suárez, Miriam
García-Quismondo, Ángel
Cañizo, F. J. del
Sánchez-Muniz, F. J.
author_role author
author2 Martínez-Suárez, Miriam
García-Quismondo, Ángel
Cañizo, F. J. del
Sánchez-Muniz, F. J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Diabesity, Inflammation, Iron status, Transferrin saturation, Waist perimeter, Type 2 diabetes
topic Diabesity, Inflammation, Iron status, Transferrin saturation, Waist perimeter, Type 2 diabetes
description [Aims]: The relationship between iron status, obesity and type 2 diabetes mellitus (T2DM) has scarcely been tested. This study hypothesizes that patients with obesity and T2DM have altered iron metabolism.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/241381
url http://hdl.handle.net/10261/241381
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103872RB-I00
https://doi.org/10.1016/j.diabres.2021.108653
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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