Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia

Objective: Few published studies have described multidisciplinary therapeutic strategies for lung cancer. This study aims to describe the different approaches used for treating lung cancer in Catalonia in 2014 and 2018 and to assess the associated cost and impact on patient survival. Methods: A retr...

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Autores: Guarga, Laura, Paco, Noelia, Clèries, Montse, Corral, Julieta, Delgadillo, Joaquim, Pontes García, Caridad, Borràs Andrés, Josep Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/192579
Acceso en línea:https://hdl.handle.net/2445/192579
Access Level:acceso abierto
Palabra clave:Càncer de pulmó
Immunoteràpia
Terapèutica
Lung cancer
Immunotheraphy
Therapeutics
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spelling Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in CataloniaGuarga, LauraPaco, NoeliaClèries, MontseCorral, JulietaDelgadillo, JoaquimPontes García, CaridadBorràs Andrés, Josep MariaCàncer de pulmóImmunoteràpiaTerapèuticaLung cancerImmunotheraphyTherapeuticsObjective: Few published studies have described multidisciplinary therapeutic strategies for lung cancer. This study aims to describe the different approaches used for treating lung cancer in Catalonia in 2014 and 2018 and to assess the associated cost and impact on patient survival. Methods: A retrospective observational cohort study using data of patients with lung cancer from health care registries in Catalonia was carried out. We analyzed change in treatment patterns, costs and survival according to the year of treatment initiation (2014 vs. 2018). The Kaplan-Meier method was used to estimate survival, with the follow-up until 2021. Results: From 2014 to 2018, the proportion of patients undergoing surgery increased and treatments for unresectable tumors decreased, mainly in younger patients. Immunotherapy increased by up to 9% by 2018. No differences in patient survival were observed within treatment patterns. The mean cost per patient in the first year of treatment increased from EUR 14,123 (standard deviation [SD] 4327) to EUR 14,550 (SD 3880) in surgical patients, from EUR 4655 (SD 3540) to EUR 5873 (SD 6455) in patients receiving curative radiotherapy and from EUR 4723 (SD 7003) to EUR 6458 (SD 10,116) in those treated for unresectable disease. Conclusions: From 2014 to 2018, surgical approaches increased in younger patients. The mean cost of treating patients increased, especially in pharmaceutical expenditure, mainly related to the use of several biomarker-targeted treatments. While no differences in overall patient survival were observed, it seems reasonable to expect improvements in this outcome in upcoming years as more patients receive innovative treatments.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/192579Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cancers14235791Cancers, 2022, vol. 14, p. 5791https://doi.org/10.3390/cancers14235791cc-by (c) Guarga, Laura et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1925792026-05-27T06:46:51Z
dc.title.none.fl_str_mv Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
title Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
spellingShingle Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
Guarga, Laura
Càncer de pulmó
Immunoteràpia
Terapèutica
Lung cancer
Immunotheraphy
Therapeutics
title_short Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
title_full Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
title_fullStr Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
title_full_unstemmed Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
title_sort Changes in treatment patterns and costs for lung cancer have not resulted in relevant improvements in survival: a population-based observational study in Catalonia
dc.creator.none.fl_str_mv Guarga, Laura
Paco, Noelia
Clèries, Montse
Corral, Julieta
Delgadillo, Joaquim
Pontes García, Caridad
Borràs Andrés, Josep Maria
author Guarga, Laura
author_facet Guarga, Laura
Paco, Noelia
Clèries, Montse
Corral, Julieta
Delgadillo, Joaquim
Pontes García, Caridad
Borràs Andrés, Josep Maria
author_role author
author2 Paco, Noelia
Clèries, Montse
Corral, Julieta
Delgadillo, Joaquim
Pontes García, Caridad
Borràs Andrés, Josep Maria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de pulmó
Immunoteràpia
Terapèutica
Lung cancer
Immunotheraphy
Therapeutics
topic Càncer de pulmó
Immunoteràpia
Terapèutica
Lung cancer
Immunotheraphy
Therapeutics
description Objective: Few published studies have described multidisciplinary therapeutic strategies for lung cancer. This study aims to describe the different approaches used for treating lung cancer in Catalonia in 2014 and 2018 and to assess the associated cost and impact on patient survival. Methods: A retrospective observational cohort study using data of patients with lung cancer from health care registries in Catalonia was carried out. We analyzed change in treatment patterns, costs and survival according to the year of treatment initiation (2014 vs. 2018). The Kaplan-Meier method was used to estimate survival, with the follow-up until 2021. Results: From 2014 to 2018, the proportion of patients undergoing surgery increased and treatments for unresectable tumors decreased, mainly in younger patients. Immunotherapy increased by up to 9% by 2018. No differences in patient survival were observed within treatment patterns. The mean cost per patient in the first year of treatment increased from EUR 14,123 (standard deviation [SD] 4327) to EUR 14,550 (SD 3880) in surgical patients, from EUR 4655 (SD 3540) to EUR 5873 (SD 6455) in patients receiving curative radiotherapy and from EUR 4723 (SD 7003) to EUR 6458 (SD 10,116) in those treated for unresectable disease. Conclusions: From 2014 to 2018, surgical approaches increased in younger patients. The mean cost of treating patients increased, especially in pharmaceutical expenditure, mainly related to the use of several biomarker-targeted treatments. While no differences in overall patient survival were observed, it seems reasonable to expect improvements in this outcome in upcoming years as more patients receive innovative treatments.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192579
url https://hdl.handle.net/2445/192579
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers14235791
Cancers, 2022, vol. 14, p. 5791
https://doi.org/10.3390/cancers14235791
dc.rights.none.fl_str_mv cc-by (c) Guarga, Laura et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Guarga, Laura et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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