Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry

Electrodeposited iridium oxide (K1.7IrO0.8 (OH)2.2 × 1.8 H2O; also called IrOx) is among the best substrates for neural growth, decreasing impedance and stimulating cell growth, when used as a connected electrode. Without direct contact, it has been proven to stimulate neurons through a bipolar mech...

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Autores: Fuentes Rodríguez, Laura, Abad Muñoz, Llibertat, Simonelli, Laura, Tonti, Dino, Casañ Pastor, Nieves
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/255264
Acesso em linha:http://hdl.handle.net/10261/255264
Access Level:Acceso aberto
Palavra-chave:Gradient materials
Electroactive
Bipolar electrochemistry
XRay absorption
Iridium oxide
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spelling Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar ElectrochemistryFuentes Rodríguez, LauraAbad Muñoz, LlibertatSimonelli, LauraTonti, DinoCasañ Pastor, NievesGradient materialsElectroactiveBipolar electrochemistryXRay absorptionIridium oxideElectrodeposited iridium oxide (K1.7IrO0.8 (OH)2.2 × 1.8 H2O; also called IrOx) is among the best substrates for neural growth, decreasing impedance and stimulating cell growth, when used as a connected electrode. Without direct contact, it has been proven to stimulate neurons through a bipolar mechanism related to the conducting character of the material in the presence of remote electric fields. The remote wireless electrostimulation that arises from it is of large significance in clinical applications. Ionic intercalation simultaneous with iridium oxidation state changes at the induced IrOx cathode and the formation of a redox and ionic gradient at the IrOx substrate is envisaged as the most probable explanation for the observed effects on neural cell growth. This work shows the iridium state gradient using X-ray absorption spectroscopy (XAS) with significant electrochemical features and relaxation times that allow for a persistent effect in the material even after the electric field creating the induced dipole is switched off. It also shows correlated intercalated sodium gradients observed by semiquantitative energy-dispersive X-ray (EDX) analysis data. The bipolar effect is proven and yields new evidence for the behavior of other biocompatible neural growth substrates.The authors thanks financing from the Ministry of Science of Spain (MAT2015-65192-R, and RTI2018-097753-B-I00), and Severo Ochoa Program (CEX2019-000917-S). LlA thanks the Ramon y Cajal Program contract (RYC-2013-12640). ALBA synchrotron experiments were performed under Grant 2020024334.Peer reviewedAmerican Chemical SocietyMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/255264reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-65192-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097753-B-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-Shttp://dx.doi.org/10.1021/acs.jpcc.1c05012Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2552642026-05-22T06:33:51Z
dc.title.none.fl_str_mv Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
title Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
spellingShingle Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
Fuentes Rodríguez, Laura
Gradient materials
Electroactive
Bipolar electrochemistry
XRay absorption
Iridium oxide
title_short Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
title_full Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
title_fullStr Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
title_full_unstemmed Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
title_sort Iridium Oxide Redox Gradient Material: Operando X-ray Absorption of Ir Gradient Oxidation States during IrOx Bipolar Electrochemistry
dc.creator.none.fl_str_mv Fuentes Rodríguez, Laura
Abad Muñoz, Llibertat
Simonelli, Laura
Tonti, Dino
Casañ Pastor, Nieves
author Fuentes Rodríguez, Laura
author_facet Fuentes Rodríguez, Laura
Abad Muñoz, Llibertat
Simonelli, Laura
Tonti, Dino
Casañ Pastor, Nieves
author_role author
author2 Abad Muñoz, Llibertat
Simonelli, Laura
Tonti, Dino
Casañ Pastor, Nieves
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gradient materials
Electroactive
Bipolar electrochemistry
XRay absorption
Iridium oxide
topic Gradient materials
Electroactive
Bipolar electrochemistry
XRay absorption
Iridium oxide
description Electrodeposited iridium oxide (K1.7IrO0.8 (OH)2.2 × 1.8 H2O; also called IrOx) is among the best substrates for neural growth, decreasing impedance and stimulating cell growth, when used as a connected electrode. Without direct contact, it has been proven to stimulate neurons through a bipolar mechanism related to the conducting character of the material in the presence of remote electric fields. The remote wireless electrostimulation that arises from it is of large significance in clinical applications. Ionic intercalation simultaneous with iridium oxidation state changes at the induced IrOx cathode and the formation of a redox and ionic gradient at the IrOx substrate is envisaged as the most probable explanation for the observed effects on neural cell growth. This work shows the iridium state gradient using X-ray absorption spectroscopy (XAS) with significant electrochemical features and relaxation times that allow for a persistent effect in the material even after the electric field creating the induced dipole is switched off. It also shows correlated intercalated sodium gradients observed by semiquantitative energy-dispersive X-ray (EDX) analysis data. The bipolar effect is proven and yields new evidence for the behavior of other biocompatible neural growth substrates.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/255264
url http://hdl.handle.net/10261/255264
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-65192-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097753-B-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-S
http://dx.doi.org/10.1021/acs.jpcc.1c05012
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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