Advanced design of radiotherapy equipment : IORT and small animal irradiators

Cancer is a major public health problem worldwide and the leading cause of death in Spain [1]. Radiotherapy plays an important role in cancer treatment with approximately 50% of all cancer patients receiving radiation therapy during the course of their illness [2], [3]. However, radiation damages bo...

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Detalles Bibliográficos
Autor: Villa Abaunza, Amaia
Tipo de recurso: tesis doctoral
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/3996
Acceso en línea:https://hdl.handle.net/20.500.14352/3996
Access Level:acceso abierto
Palabra clave:615.849.1(043.2)
Radiotherapy
Radioterapia
Diagnóstico por imagen y medicina nuclear
3204.01 Medicina Nuclear
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spelling Advanced design of radiotherapy equipment : IORT and small animal irradiatorsVilla Abaunza, Amaia615.849.1(043.2)RadiotherapyRadioterapiaDiagnóstico por imagen y medicina nuclear3204.01 Medicina NuclearCancer is a major public health problem worldwide and the leading cause of death in Spain [1]. Radiotherapy plays an important role in cancer treatment with approximately 50% of all cancer patients receiving radiation therapy during the course of their illness [2], [3]. However, radiation damages both healthy and cancerous tissues and improving the therapeutic index (the relationship between the probability of tumor control and the likelihood of normal tissue damage) is a constant challenge in radiotherapy [4]. Consequently, optimizing treatment plans (TP) is of utmost importance [5]. In this thesis we present two projects in collaboration with GMV [6] and SEDECAL [7] that aim to this goal. On the one hand, we propose a design for a small animal x-ray irradiator to be used in preclinical research. This kind of devices serve to downscale the clinical scenario to the laboratory in order to study the radiobiological response and improve clinical outcomes [8]. Our proposal consists of a conventional X-ray tube and a self-shielded cabinet, which make the system affordable and suitable to use without disruption inexisting laboratories...Universidad Complutense de MadridUdías Moinelo, José ManuelIbáñez García, Paula BeatrizLópez Herraiz, JoaquínUniversidad Complutense de Madrid20222022-11-2920222022-11-29doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/3996reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/39962026-06-02T12:44:21Z
dc.title.none.fl_str_mv Advanced design of radiotherapy equipment : IORT and small animal irradiators
title Advanced design of radiotherapy equipment : IORT and small animal irradiators
spellingShingle Advanced design of radiotherapy equipment : IORT and small animal irradiators
Villa Abaunza, Amaia
615.849.1(043.2)
Radiotherapy
Radioterapia
Diagnóstico por imagen y medicina nuclear
3204.01 Medicina Nuclear
title_short Advanced design of radiotherapy equipment : IORT and small animal irradiators
title_full Advanced design of radiotherapy equipment : IORT and small animal irradiators
title_fullStr Advanced design of radiotherapy equipment : IORT and small animal irradiators
title_full_unstemmed Advanced design of radiotherapy equipment : IORT and small animal irradiators
title_sort Advanced design of radiotherapy equipment : IORT and small animal irradiators
dc.creator.none.fl_str_mv Villa Abaunza, Amaia
author Villa Abaunza, Amaia
author_facet Villa Abaunza, Amaia
author_role author
dc.contributor.none.fl_str_mv Udías Moinelo, José Manuel
Ibáñez García, Paula Beatriz
López Herraiz, Joaquín
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.849.1(043.2)
Radiotherapy
Radioterapia
Diagnóstico por imagen y medicina nuclear
3204.01 Medicina Nuclear
topic 615.849.1(043.2)
Radiotherapy
Radioterapia
Diagnóstico por imagen y medicina nuclear
3204.01 Medicina Nuclear
description Cancer is a major public health problem worldwide and the leading cause of death in Spain [1]. Radiotherapy plays an important role in cancer treatment with approximately 50% of all cancer patients receiving radiation therapy during the course of their illness [2], [3]. However, radiation damages both healthy and cancerous tissues and improving the therapeutic index (the relationship between the probability of tumor control and the likelihood of normal tissue damage) is a constant challenge in radiotherapy [4]. Consequently, optimizing treatment plans (TP) is of utmost importance [5]. In this thesis we present two projects in collaboration with GMV [6] and SEDECAL [7] that aim to this goal. On the one hand, we propose a design for a small animal x-ray irradiator to be used in preclinical research. This kind of devices serve to downscale the clinical scenario to the laboratory in order to study the radiobiological response and improve clinical outcomes [8]. Our proposal consists of a conventional X-ray tube and a self-shielded cabinet, which make the system affordable and suitable to use without disruption inexisting laboratories...
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-11-29
2022
2022-11-29
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/3996
url https://hdl.handle.net/20.500.14352/3996
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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