Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies

Methylphenidate (MPH) is the first-line treatment for Attention-Deficit/Hyperactivity Disorder (ADHD), a condition that disrupts daily functioning. Research indicates that individuals with ADHD often experience sensory processing impairments, regardless of co-occurring conditions. Given the growing...

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Autores: Recarey Rama, Sheila, Conde Pumpido Zubizarreta, Sabela, Brenlla Lorenzo, Carla, Gerpe Rieiro, Eva, Gil Rodríguez, Almudena, Tubío Fungueiriño, María, Pozo Rodríguez, Marta, Carracedo Álvarez, Ángel, Maroñas Amigo, Olalla, Fernández Prieto, Montserrat
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/43741
Acceso en línea:https://hdl.handle.net/10347/43741
Access Level:acceso abierto
Palabra clave:ADHD
Methylphenidate
Stimulants
Sensory profile
Sensory processing
Pharmacogenetics
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spelling Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studiesRecarey Rama, SheilaConde Pumpido Zubizarreta, SabelaBrenlla Lorenzo, CarlaGerpe Rieiro, EvaGil Rodríguez, AlmudenaTubío Fungueiriño, MaríaPozo Rodríguez, MartaCarracedo Álvarez, ÁngelMaroñas Amigo, OlallaFernández Prieto, MontserratADHDMethylphenidateStimulantsSensory profileSensory processingPharmacogeneticsMethylphenidate (MPH) is the first-line treatment for Attention-Deficit/Hyperactivity Disorder (ADHD), a condition that disrupts daily functioning. Research indicates that individuals with ADHD often experience sensory processing impairments, regardless of co-occurring conditions. Given the growing interest in pharmacogenetics to personalise treatments and minimise side effects, this study aims to characterise the sensory profiles of in child and youth ADHD patients treated with MPH and investigate potential pharmacogenetic biomarkers that could be associated with treatment outcomes or sensory-related side effects. Following PRISMA guidelines, a systematic review focused on sensory profiles in ADHD patients receiving MPH and the pharmacogenetic biomarkers that might explain their sensory processing while on MPH treatment was conducted using four major databases (PubMed, Web of Science, PsycINFO, and Scopus) to include studies from the past 25 years. After screening 568 articles, seven studies met the inclusion criteria. None of them aimed to study pharmacogenetic biomarkers related to sensory outcomes. Findings showed that ADHD children treated with MPH had improved pain perception and postural balance but worse odour discrimination compared to unmedicated patients. Other sensory factors, such as noise sensitivity and odour identification, did not yield statistically significant results. Further research is needed to understand the mechanisms behind sensory processing differences, as well as the impact of factors such as sex and co-medication. Furthermore, the gap in understanding pharmacogenetic biomarkers for sensory responses suggests new research questions, which could ultimately improve diagnostic and therapeutic strategies for ADHD and sensory-related disorders.ElsevierUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS)20252025-09-0220252025-09-02journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/43741reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/437412026-06-15T12:47:27Z
dc.title.none.fl_str_mv Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
title Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
spellingShingle Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
Recarey Rama, Sheila
ADHD
Methylphenidate
Stimulants
Sensory profile
Sensory processing
Pharmacogenetics
title_short Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
title_full Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
title_fullStr Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
title_full_unstemmed Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
title_sort Exploring the sensory profile and pharmacogenetic biomarkers in child and youth ADHD patients undergoing methylphenidate (MPH) treatment: a systematic review conducted in European studies
dc.creator.none.fl_str_mv Recarey Rama, Sheila
Conde Pumpido Zubizarreta, Sabela
Brenlla Lorenzo, Carla
Gerpe Rieiro, Eva
Gil Rodríguez, Almudena
Tubío Fungueiriño, María
Pozo Rodríguez, Marta
Carracedo Álvarez, Ángel
Maroñas Amigo, Olalla
Fernández Prieto, Montserrat
author Recarey Rama, Sheila
author_facet Recarey Rama, Sheila
Conde Pumpido Zubizarreta, Sabela
Brenlla Lorenzo, Carla
Gerpe Rieiro, Eva
Gil Rodríguez, Almudena
Tubío Fungueiriño, María
Pozo Rodríguez, Marta
Carracedo Álvarez, Ángel
Maroñas Amigo, Olalla
Fernández Prieto, Montserrat
author_role author
author2 Conde Pumpido Zubizarreta, Sabela
Brenlla Lorenzo, Carla
Gerpe Rieiro, Eva
Gil Rodríguez, Almudena
Tubío Fungueiriño, María
Pozo Rodríguez, Marta
Carracedo Álvarez, Ángel
Maroñas Amigo, Olalla
Fernández Prieto, Montserrat
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS)
dc.subject.none.fl_str_mv ADHD
Methylphenidate
Stimulants
Sensory profile
Sensory processing
Pharmacogenetics
topic ADHD
Methylphenidate
Stimulants
Sensory profile
Sensory processing
Pharmacogenetics
description Methylphenidate (MPH) is the first-line treatment for Attention-Deficit/Hyperactivity Disorder (ADHD), a condition that disrupts daily functioning. Research indicates that individuals with ADHD often experience sensory processing impairments, regardless of co-occurring conditions. Given the growing interest in pharmacogenetics to personalise treatments and minimise side effects, this study aims to characterise the sensory profiles of in child and youth ADHD patients treated with MPH and investigate potential pharmacogenetic biomarkers that could be associated with treatment outcomes or sensory-related side effects. Following PRISMA guidelines, a systematic review focused on sensory profiles in ADHD patients receiving MPH and the pharmacogenetic biomarkers that might explain their sensory processing while on MPH treatment was conducted using four major databases (PubMed, Web of Science, PsycINFO, and Scopus) to include studies from the past 25 years. After screening 568 articles, seven studies met the inclusion criteria. None of them aimed to study pharmacogenetic biomarkers related to sensory outcomes. Findings showed that ADHD children treated with MPH had improved pain perception and postural balance but worse odour discrimination compared to unmedicated patients. Other sensory factors, such as noise sensitivity and odour identification, did not yield statistically significant results. Further research is needed to understand the mechanisms behind sensory processing differences, as well as the impact of factors such as sex and co-medication. Furthermore, the gap in understanding pharmacogenetic biomarkers for sensory responses suggests new research questions, which could ultimately improve diagnostic and therapeutic strategies for ADHD and sensory-related disorders.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-09-02
2025
2025-09-02
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/43741
url https://hdl.handle.net/10347/43741
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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