Marine Arthropods as a Source of Antimicrobial Peptides

Peptide therapeutics play a key role in the development of new medical treatments. The traditional focus on endogenous peptides has shifted from first discovering other natural sources of these molecules, to later synthesizing those with unique bioactivities. This review provides concise information...

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Detalles Bibliográficos
Autores: Saucedo-Vázquez, Juan Pablo, Gushque, Fernando, Vispo, Nelson Santiago, Rodriguez, Jenny, Gudiño-Gomezjurado, Marco Esteban, Albericio, Fernando, Tellkamp, Markus P., Alexis, Frank
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/278761
Acceso en línea:http://hdl.handle.net/10261/278761
https://api.elsevier.com/content/abstract/scopus_id/85136478974
Access Level:acceso abierto
Palabra clave:Shrimp
AMP
Antimicrobial peptides
Crustaceans
Defense system
Drug
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spelling Marine Arthropods as a Source of Antimicrobial PeptidesSaucedo-Vázquez, Juan PabloGushque, FernandoVispo, Nelson SantiagoRodriguez, JennyGudiño-Gomezjurado, Marco EstebanAlbericio, FernandoTellkamp, Markus P.Alexis, FrankShrimpAMPAntimicrobial peptidesCrustaceansDefense systemDrugPeptide therapeutics play a key role in the development of new medical treatments. The traditional focus on endogenous peptides has shifted from first discovering other natural sources of these molecules, to later synthesizing those with unique bioactivities. This review provides concise information concerning antimicrobial peptides derived from marine crustaceans for the development of new therapeutics. Marine arthropods do not have an adaptive immune system, and therefore, they depend on the innate immune system to eliminate pathogens. In this context, antimicrobial peptides (AMPs) with unique characteristics are a pivotal part of the defense systems of these organisms. This review covers topics such as the diversity and distribution of peptides in marine arthropods (crustacea and chelicerata), with a focus on penaeid shrimps. The following aspects are covered: the defense system; classes of AMPs; molecular characteristics of AMPs; AMP synthesis; the role of penaeidins, anti-lipopolysaccharide factors, crustins, and stylicins against microorganisms; and the use of AMPs as therapeutic drugs. This review seeks to provide a useful compilation of the most recent information regarding AMPs from marine crustaceans, and describes the future potential applications of these molecules.The work in the laboratory of the authors was funded in part by: Yachay Tech (Internal project CHEM19-10), the Universidad San Francisco de Quito, and the University of KwaZulu-Natal: National Research Foundation (NRF) (# 105892 and Blue Sky’s Research Programme # 120386) & Marató TV3 foundation Project BARNAPA (FA).Peer reviewedMultidisciplinary Digital Publishing Institute0000-0002-4314-63630000-0002-4081-39840000-0002-4773-07000000-0002-8609-08060000-0002-8946-04620000-0002-0597-7940Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/278761https://api.elsevier.com/content/abstract/scopus_id/85136478974reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésMarine drugshttps://doi.org/10.3390/md20080501Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2787612026-05-22T06:33:51Z
dc.title.none.fl_str_mv Marine Arthropods as a Source of Antimicrobial Peptides
title Marine Arthropods as a Source of Antimicrobial Peptides
spellingShingle Marine Arthropods as a Source of Antimicrobial Peptides
Saucedo-Vázquez, Juan Pablo
Shrimp
AMP
Antimicrobial peptides
Crustaceans
Defense system
Drug
title_short Marine Arthropods as a Source of Antimicrobial Peptides
title_full Marine Arthropods as a Source of Antimicrobial Peptides
title_fullStr Marine Arthropods as a Source of Antimicrobial Peptides
title_full_unstemmed Marine Arthropods as a Source of Antimicrobial Peptides
title_sort Marine Arthropods as a Source of Antimicrobial Peptides
dc.creator.none.fl_str_mv Saucedo-Vázquez, Juan Pablo
Gushque, Fernando
Vispo, Nelson Santiago
Rodriguez, Jenny
Gudiño-Gomezjurado, Marco Esteban
Albericio, Fernando
Tellkamp, Markus P.
Alexis, Frank
author Saucedo-Vázquez, Juan Pablo
author_facet Saucedo-Vázquez, Juan Pablo
Gushque, Fernando
Vispo, Nelson Santiago
Rodriguez, Jenny
Gudiño-Gomezjurado, Marco Esteban
Albericio, Fernando
Tellkamp, Markus P.
Alexis, Frank
author_role author
author2 Gushque, Fernando
Vispo, Nelson Santiago
Rodriguez, Jenny
Gudiño-Gomezjurado, Marco Esteban
Albericio, Fernando
Tellkamp, Markus P.
Alexis, Frank
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv 0000-0002-4314-6363
0000-0002-4081-3984
0000-0002-4773-0700
0000-0002-8609-0806
0000-0002-8946-0462
0000-0002-0597-7940
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Shrimp
AMP
Antimicrobial peptides
Crustaceans
Defense system
Drug
topic Shrimp
AMP
Antimicrobial peptides
Crustaceans
Defense system
Drug
description Peptide therapeutics play a key role in the development of new medical treatments. The traditional focus on endogenous peptides has shifted from first discovering other natural sources of these molecules, to later synthesizing those with unique bioactivities. This review provides concise information concerning antimicrobial peptides derived from marine crustaceans for the development of new therapeutics. Marine arthropods do not have an adaptive immune system, and therefore, they depend on the innate immune system to eliminate pathogens. In this context, antimicrobial peptides (AMPs) with unique characteristics are a pivotal part of the defense systems of these organisms. This review covers topics such as the diversity and distribution of peptides in marine arthropods (crustacea and chelicerata), with a focus on penaeid shrimps. The following aspects are covered: the defense system; classes of AMPs; molecular characteristics of AMPs; AMP synthesis; the role of penaeidins, anti-lipopolysaccharide factors, crustins, and stylicins against microorganisms; and the use of AMPs as therapeutic drugs. This review seeks to provide a useful compilation of the most recent information regarding AMPs from marine crustaceans, and describes the future potential applications of these molecules.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/278761
https://api.elsevier.com/content/abstract/scopus_id/85136478974
url http://hdl.handle.net/10261/278761
https://api.elsevier.com/content/abstract/scopus_id/85136478974
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Marine drugs
https://doi.org/10.3390/md20080501
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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