Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices

In this study, differences in autonomic reactivity to mental stress between Major Depressive Disorder (MDD) patients and healthy control (HC) subjects are assessed by nonlinear cardiorespiratory coupling indices derived from the Real Wavelet Biphase. The degree and strength of Quadratic Phase Coupli...

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Authors: Kontaxis, Spyridon, Laguna, Pablo, García Pages, Esther, Posadas-de Miguel, Mar, Siddi, Sara, Luisa Bernal, Maria, Maria Haro, Josep, Aguiló, Jordi, de la Camara, Concepción, Bailón, Raquel, Gil, Eduardo
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Universidad de Zaragoza
Repository:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:121352
Online Access:http://zaguan.unizar.es/record/121352
Access Level:Open access
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spelling Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indicesKontaxis, SpyridonLaguna, PabloGarcía Pages, EstherPosadas-de Miguel, MarSiddi, SaraLuisa Bernal, MariaMaria Haro, JosepAguiló, Jordide la Camara, ConcepciónBailón, RaquelGil, EduardoIn this study, differences in autonomic reactivity to mental stress between Major Depressive Disorder (MDD) patients and healthy control (HC) subjects are assessed by nonlinear cardiorespiratory coupling indices derived from the Real Wavelet Biphase. The degree and strength of Quadratic Phase Coupling (QPC) between interacting oscillations of Heart Rate Variability (HRV) and respiration are quantified before, during and after the execution of acognitive task. Results show that the QPC strength and QPC degree between the respiration and the respiratory sinus arrhythmia component of HRV were lower in HC compared to MDD during stress, suggesting that the parasympathetic branch was less inhibited in MDD patients. During recovery, only in HC group, this degree of QPC increased, while the respiratory rate was reduced, compared to the basal stage. The degree of QPC between the respiration and components of HRV in the low frequency band ([0.04, 0.15] Hz) increased in HC during stress, compared to the basal stage, while remained unchanged in MDD patients. These results imply that depression is associated with blunted autonomic reactivity to mental stress2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/121352reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/AEI-FEDER/RTI2018-097723-B-I00info:eu-repo/grantAgreement/ES/DGA-FSE/LMP44-18info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS groupinfo:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBNinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1213522026-05-29T13:59:51Z
dc.title.none.fl_str_mv Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
title Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
spellingShingle Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
Kontaxis, Spyridon
title_short Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
title_full Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
title_fullStr Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
title_full_unstemmed Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
title_sort Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices
dc.creator.none.fl_str_mv Kontaxis, Spyridon
Laguna, Pablo
García Pages, Esther
Posadas-de Miguel, Mar
Siddi, Sara
Luisa Bernal, Maria
Maria Haro, Josep
Aguiló, Jordi
de la Camara, Concepción
Bailón, Raquel
Gil, Eduardo
author Kontaxis, Spyridon
author_facet Kontaxis, Spyridon
Laguna, Pablo
García Pages, Esther
Posadas-de Miguel, Mar
Siddi, Sara
Luisa Bernal, Maria
Maria Haro, Josep
Aguiló, Jordi
de la Camara, Concepción
Bailón, Raquel
Gil, Eduardo
author_role author
author2 Laguna, Pablo
García Pages, Esther
Posadas-de Miguel, Mar
Siddi, Sara
Luisa Bernal, Maria
Maria Haro, Josep
Aguiló, Jordi
de la Camara, Concepción
Bailón, Raquel
Gil, Eduardo
author2_role author
author
author
author
author
author
author
author
author
author
description In this study, differences in autonomic reactivity to mental stress between Major Depressive Disorder (MDD) patients and healthy control (HC) subjects are assessed by nonlinear cardiorespiratory coupling indices derived from the Real Wavelet Biphase. The degree and strength of Quadratic Phase Coupling (QPC) between interacting oscillations of Heart Rate Variability (HRV) and respiration are quantified before, during and after the execution of acognitive task. Results show that the QPC strength and QPC degree between the respiration and the respiratory sinus arrhythmia component of HRV were lower in HC compared to MDD during stress, suggesting that the parasympathetic branch was less inhibited in MDD patients. During recovery, only in HC group, this degree of QPC increased, while the respiratory rate was reduced, compared to the basal stage. The degree of QPC between the respiration and components of HRV in the low frequency band ([0.04, 0.15] Hz) increased in HC during stress, compared to the basal stage, while remained unchanged in MDD patients. These results imply that depression is associated with blunted autonomic reactivity to mental stress
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/121352
url http://zaguan.unizar.es/record/121352
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/AEI-FEDER/RTI2018-097723-B-I00
info:eu-repo/grantAgreement/ES/DGA-FSE/LMP44-18
info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
repository.name.fl_str_mv
repository.mail.fl_str_mv
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