Behavioural and molecular effects of cannabidiolic acid in mice

Background: cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis Sativa plant. It has been shown to exert some therapeutic effects such as antiemetic, anti-inflammatory, anxiolytic or antidepressant, although some of them with controversy. Hypothesis/Purpose:...

Descripción completa

Detalles Bibliográficos
Autores: Alegre Zurano, Laia, Martín Sánchez, Ana, Valverde Granados, Olga
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/72152
Acceso en línea:https://hdl.handle.net/10230/72152
http://dx.doi.org/10.1016/j.lfs.2020.118271
http://hdl.handle.net/10230/72152
Access Level:acceso abierto
Palabra clave:Cannabidiolic acid
Cocaine
Behaviour
Inflammation
id ES_bc2bca368b33237783271e88620e2b8e
oai_identifier_str oai:recercat.cat:10230/72152
network_acronym_str ES
network_name_str España
repository_id_str
spelling Behavioural and molecular effects of cannabidiolic acid in miceAlegre Zurano, LaiaMartín Sánchez, AnaValverde Granados, OlgaCannabidiolic acidCocaineBehaviourInflammationBackground: cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis Sativa plant. It has been shown to exert some therapeutic effects such as antiemetic, anti-inflammatory, anxiolytic or antidepressant, although some of them with controversy. Hypothesis/Purpose: assess the potential effects of CBDA on different behaviours and on the modulation of neuroinflammatory markers in the prefrontal cortex (PFC). Study Design: the effects of CBDA were evaluated on cognitive, emotional, motivational and nociceptive behaviours in male CD1 mice. Methods: acute and/or chronic CBDA treatment (0.001-1 mg/kg i.p.) was evaluated in cognitive, emotional and nociceptive behavioural models, using the Y-maze, spontaneous locomotor activity, social interaction test, elevated plus maze, hot-plate test, formalin test and tail-suspension test in mice. We also assessed the effects of CBDA on the rewarding responses of cocaine in the conditioned place preference paradigm. PFC was dissected after acute and chronic CBDA treatments to evaluate inflammatory markers. Results: acute CBDA induced antinociceptive effects in the hot plate test. A 10-days chronic CBDA treatment also showed an effect on despair-like behaviour in the tail suspension test. CBDA did not show any other effect in the remaining behavioural tests assayed, including the cocaine-induced conditioned place preference (CPP). Regarding the biochemical analysis, chronic CBDA treatment diminished peroxisome proliferator-activated receptor gamma (PPAR-γ) and increased interleukin-6 (IL-6) protein levels in PFC. Conclusion: these results show that CBDA has “in vivo” limited effects modulating mice behaviour and highlight the lack of agreement regarding its therapeutic potential.Elsevier2026202620202026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72152http://dx.doi.org/10.1016/j.lfs.2020.118271http://hdl.handle.net/10230/72152reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésLife Sciences. 2020;259:118271© Elsevier http://dx.doi.org/10.1016/j.lfs.2020.118271info:eu-repo/semantics/openAccessoai:recercat.cat:10230/721522026-05-29T05:05:01Z
dc.title.none.fl_str_mv Behavioural and molecular effects of cannabidiolic acid in mice
title Behavioural and molecular effects of cannabidiolic acid in mice
spellingShingle Behavioural and molecular effects of cannabidiolic acid in mice
Alegre Zurano, Laia
Cannabidiolic acid
Cocaine
Behaviour
Inflammation
title_short Behavioural and molecular effects of cannabidiolic acid in mice
title_full Behavioural and molecular effects of cannabidiolic acid in mice
title_fullStr Behavioural and molecular effects of cannabidiolic acid in mice
title_full_unstemmed Behavioural and molecular effects of cannabidiolic acid in mice
title_sort Behavioural and molecular effects of cannabidiolic acid in mice
dc.creator.none.fl_str_mv Alegre Zurano, Laia
Martín Sánchez, Ana
Valverde Granados, Olga
author Alegre Zurano, Laia
author_facet Alegre Zurano, Laia
Martín Sánchez, Ana
Valverde Granados, Olga
author_role author
author2 Martín Sánchez, Ana
Valverde Granados, Olga
author2_role author
author
dc.subject.none.fl_str_mv Cannabidiolic acid
Cocaine
Behaviour
Inflammation
topic Cannabidiolic acid
Cocaine
Behaviour
Inflammation
description Background: cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis Sativa plant. It has been shown to exert some therapeutic effects such as antiemetic, anti-inflammatory, anxiolytic or antidepressant, although some of them with controversy. Hypothesis/Purpose: assess the potential effects of CBDA on different behaviours and on the modulation of neuroinflammatory markers in the prefrontal cortex (PFC). Study Design: the effects of CBDA were evaluated on cognitive, emotional, motivational and nociceptive behaviours in male CD1 mice. Methods: acute and/or chronic CBDA treatment (0.001-1 mg/kg i.p.) was evaluated in cognitive, emotional and nociceptive behavioural models, using the Y-maze, spontaneous locomotor activity, social interaction test, elevated plus maze, hot-plate test, formalin test and tail-suspension test in mice. We also assessed the effects of CBDA on the rewarding responses of cocaine in the conditioned place preference paradigm. PFC was dissected after acute and chronic CBDA treatments to evaluate inflammatory markers. Results: acute CBDA induced antinociceptive effects in the hot plate test. A 10-days chronic CBDA treatment also showed an effect on despair-like behaviour in the tail suspension test. CBDA did not show any other effect in the remaining behavioural tests assayed, including the cocaine-induced conditioned place preference (CPP). Regarding the biochemical analysis, chronic CBDA treatment diminished peroxisome proliferator-activated receptor gamma (PPAR-γ) and increased interleukin-6 (IL-6) protein levels in PFC. Conclusion: these results show that CBDA has “in vivo” limited effects modulating mice behaviour and highlight the lack of agreement regarding its therapeutic potential.
publishDate 2020
dc.date.none.fl_str_mv 2020
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/72152
http://dx.doi.org/10.1016/j.lfs.2020.118271
http://hdl.handle.net/10230/72152
url https://hdl.handle.net/10230/72152
http://dx.doi.org/10.1016/j.lfs.2020.118271
http://hdl.handle.net/10230/72152
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Life Sciences. 2020;259:118271
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.lfs.2020.118271
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.lfs.2020.118271
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418090033315840
score 15.81155

Similares en LA Referencia