A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy

Anthracycline-based cancer chemotherapy (ACC) causes myocardial fibrosis, a lesion contributing to left ventricular dysfunction (LVD). We investigated whether the procollagen-derived type-I C-terminal-propeptide (PICP): (1) associates with subclinical LVD (sLVD) at 3-months after ACC (3m-post-ACC);...

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Detalhes bibliográficos
Autores: Fuente-Villena, A. (Ana) de la|||/items/cdf4cb33-e112-4491-9043-fa0f43b6ecea, Santisteban-Eslava, M. (Marta)|||/items/563d2cef-8a22-4110-97f4-8e16eac15419, Lupón, J. (Josep)|||/items/2033f405-944c-481f-ae52-def2a825c23d, Aramendia, J.M. (José Manuel)|||/items/2e93a3c3-48eb-4a03-9a90-9dc6e7be7a61, Díaz-Dorronsoro, I. (Inés)|||/items/eb812d3a-1796-4950-b894-c77b1b522c41, Santaballa, A. (Ana)|||/items/8ef9f524-e335-4f4c-bcac-42eb489645ab, Hernándiz, A. (Amparo)|||/items/748bcd51-c3f4-4d47-8751-c188eee7f692, Sepúlveda, P. (Pilar)|||/items/6812bc9d-bb9a-4561-89bc-40e4434b0799, Cediel, G. (Germán)|||/items/f9133520-f751-4e7d-b666-5908e3c122ad, Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0, Lopez-Picazo, J.M. (José María)|||/items/1a2fbd26-96ec-4587-b2d2-8f6ea1f707de, Mazo-Vega, M.M. (Manuel María)|||/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e, Rabago, G. (Gregorio)|||/items/80ea8921-99e9-46db-b2f0-5bf236e53534, Gavira-Gómez, J.J. (Juan José)|||/items/a253ead5-4ef7-4b80-9aab-43b47605270e, Garcia-Bolao, I. (Ignacio)|||/items/c29cdf3e-401f-4293-b138-6843f6f6bf5b, Diez, J. (Javier)|||/items/adeda0be-cebc-4240-899c-ab26f05dea9c, Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515, Bayes-Genis, A. (Antoni)|||/items/896bbeec-9322-439b-a042-fd865eaa7f6f, Ravassa-Albéniz, S. (Susana)|||/items/df0c1eb3-9f45-4d77-a7a5-aca2bcf425e1
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/68718
Acesso em linha:https://hdl.handle.net/10171/68718
Access Level:acceso abierto
Palavra-chave:Anthracycline-based chemotherapy
Biomarkers
Cardiotoxicity
Global longitudinal strain
Myocardial fibrosis
Área del Cáncer de Mama
Descrição
Resumo:Anthracycline-based cancer chemotherapy (ACC) causes myocardial fibrosis, a lesion contributing to left ventricular dysfunction (LVD). We investigated whether the procollagen-derived type-I C-terminal-propeptide (PICP): (1) associates with subclinical LVD (sLVD) at 3-months after ACC (3m-post-ACC); (2) predicts cardiotoxicity 1-year after ACC (12m-post-ACC) in breast cancer patients (BC-patients); and (3) associates with LVD in ACC-induced heart failure patients (ACC-HF-patients). Echocardiography, serum PICP and biomarkers of cardiomyocyte damage were assessed in two independent cohorts of BC-patients: CUN (n = 87) at baseline, post-ACC, and 3m and 12m (n = 65)-post-ACC; and HULAFE (n = 70) at baseline, 3m and 12m-post-ACC. Thirty-seven ACC-HF-patients were also studied. Global longitudinal strain (GLS)-based sLVD (3m-post-ACC) and LV ejection fraction (LVEF)-based cardiotoxicity (12m-post-ACC) were defined according to guidelines. BC-patients: all biomarkers increased at 3m-post-ACC versus baseline. PICP was particularly increased in patients with sLVD (interaction-p < 0.001) and was associated with GLS (p < 0.001). PICP increase at 3m-post-ACC predicted cardiotoxicity at 12m-post-ACC (odds-ratio ≥ 2.95 per doubling PICP, p ≤ 0.025) in both BC-cohorts, adding prognostic value to the early assessment of GLS and LVEF. ACC-HF-patients: PICP was inversely associated with LVEF (p = 0.004). In ACC-treated BC-patients, an early increase in PICP is associated with early sLVD and predicts cardiotoxicity 1 year after ACC. PICP is also associated with LVD in ACC-HF-patients.

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