Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application

This article belongs to the Special Issue Liposomal and Ethosomal Gels: From Design to Application (2nd Edition).

Detalles Bibliográficos
Autores: Vergara, Daniela, Vega, Benjamín, Sanhueza, Claudia, Bustamante, Mariela, Acevedo, Francisca, López, Olga
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/421516
Acceso en línea:http://hdl.handle.net/10261/421516
Access Level:acceso abierto
Palabra clave:Thermosensitive hydrogel
Liposome
Curcumin
Delivery system
Topical administration
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spelling Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin ApplicationVergara, DanielaVega, BenjamínSanhueza, ClaudiaBustamante, MarielaAcevedo, FranciscaLópez, OlgaThermosensitive hydrogelLiposomeCurcuminDelivery systemTopical administrationThis article belongs to the Special Issue Liposomal and Ethosomal Gels: From Design to Application (2nd Edition).A novel co-encapsulation platform based on curcumin-loaded liposomes (Cur-Lip) incorporated into thermosensitive hydrogels (TSH) was developed to address the physicochemical and biological limitations of topical curcumin (Cur) delivery. Response Surface Methodology (RSM) was used to optimize Pluronic® F-127, glycerol, and alginate concentrations with respect to gelation time and viscosity. The optimized formulation (22% Pluronic® F-127, 5% glycerol, and 0.5% alginate) exhibited rapid time sol–gel transition (~86 s), suitable viscosity (~377 mPa·s), excellent model fitting (R2 = 0.99) and prediction accuracy. Three formulations (TSH, Cur-TSH, and Cur-Lip-TSH) were subsequently prepared and displayed appropriate thermoresponsive behavior. The Cur-Lip system showed high encapsulation efficiency (~78%). Upon incorporation into the TSH, Cur-Lip-TSH displayed increased viscosity and mechanical strength at physiological temperature. In vitro studies confirmed its cytocompatibility toward human keratinocytes, significant antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa, and no irritation potential as assessed by the Hen’s Egg Test on the Chorioallantoic Membrane assay (HET-CAM). Overall, Cur-Lip-TSH represents a safe and robust thermosensitive platform that provides a foundation for future studies on controlled curcumin release and topical performance.This research was funded by the Agencia Nacional de Investigación y Desarrollo (ANID) from the Chilean Government through FONDECYT Iniciación Project No. 11240998.Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Nacional de Investigación y Desarrollo (Chile)Vergara, Daniela [0009-0009-0654-2322]Acevedo, Francisca [0000-0002-7060-0656]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2026202620262026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/421516reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/gels12020181https://doi.org/10.3390/gels12020181Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4215162026-05-22T06:33:51Z
dc.title.none.fl_str_mv Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
title Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
spellingShingle Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
Vergara, Daniela
Thermosensitive hydrogel
Liposome
Curcumin
Delivery system
Topical administration
title_short Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
title_full Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
title_fullStr Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
title_full_unstemmed Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
title_sort Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application
dc.creator.none.fl_str_mv Vergara, Daniela
Vega, Benjamín
Sanhueza, Claudia
Bustamante, Mariela
Acevedo, Francisca
López, Olga
author Vergara, Daniela
author_facet Vergara, Daniela
Vega, Benjamín
Sanhueza, Claudia
Bustamante, Mariela
Acevedo, Francisca
López, Olga
author_role author
author2 Vega, Benjamín
Sanhueza, Claudia
Bustamante, Mariela
Acevedo, Francisca
López, Olga
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Nacional de Investigación y Desarrollo (Chile)
Vergara, Daniela [0009-0009-0654-2322]
Acevedo, Francisca [0000-0002-7060-0656]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Thermosensitive hydrogel
Liposome
Curcumin
Delivery system
Topical administration
topic Thermosensitive hydrogel
Liposome
Curcumin
Delivery system
Topical administration
description This article belongs to the Special Issue Liposomal and Ethosomal Gels: From Design to Application (2nd Edition).
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/421516
url http://hdl.handle.net/10261/421516
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/gels12020181
https://doi.org/10.3390/gels12020181
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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