How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?

Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to...

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Autores: González-García, Pablo, Alonso-Sardón, Montserrat, Rodríguez-Alonso, Beatriz, Almeida, Hugo, Romero-Alegría, Ángela, Vega-Rodríguez, Víctor José, López-Bernús, Amparo, Muñoz-Bellido, Juan Luis, Muro, Antonio, Pardo Lledias, Javier, Belhassen-García, Moncef
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/280448
Acesso em linha:http://hdl.handle.net/10261/280448
Access Level:acceso abierto
Palavra-chave:Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
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network_name_str España
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spelling How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?González-García, PabloAlonso-Sardón, MontserratRodríguez-Alonso, BeatrizAlmeida, HugoRomero-Alegría, ÁngelaVega-Rodríguez, Víctor JoséLópez-Bernús, AmparoMuñoz-Bellido, Juan LuisMuro, AntonioPardo Lledias, JavierBelhassen-García, MoncefAspergillosisHuman aspergillosisInvasive fungal diseasesCase fatality rateSpainBackground: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997–1998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence/association significantly increased case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19.Peer reviewedMolecular Diversity Preservation InternationalVega-Rodríguez, Víctor José [0000-0001-9294-564X]Muñoz-Bellido, Juan Luis [0000-0002-5981-8785]Muro, Antonio [0000-0003-0244-4740]Belhassen-García, Moncef [0000-0002-2230-1256]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/280448reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/jof8060576Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2804482026-05-22T06:33:51Z
dc.title.none.fl_str_mv How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
title How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
spellingShingle How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
González-García, Pablo
Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
title_short How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
title_full How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
title_fullStr How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
title_full_unstemmed How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
title_sort How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
dc.creator.none.fl_str_mv González-García, Pablo
Alonso-Sardón, Montserrat
Rodríguez-Alonso, Beatriz
Almeida, Hugo
Romero-Alegría, Ángela
Vega-Rodríguez, Víctor José
López-Bernús, Amparo
Muñoz-Bellido, Juan Luis
Muro, Antonio
Pardo Lledias, Javier
Belhassen-García, Moncef
author González-García, Pablo
author_facet González-García, Pablo
Alonso-Sardón, Montserrat
Rodríguez-Alonso, Beatriz
Almeida, Hugo
Romero-Alegría, Ángela
Vega-Rodríguez, Víctor José
López-Bernús, Amparo
Muñoz-Bellido, Juan Luis
Muro, Antonio
Pardo Lledias, Javier
Belhassen-García, Moncef
author_role author
author2 Alonso-Sardón, Montserrat
Rodríguez-Alonso, Beatriz
Almeida, Hugo
Romero-Alegría, Ángela
Vega-Rodríguez, Víctor José
López-Bernús, Amparo
Muñoz-Bellido, Juan Luis
Muro, Antonio
Pardo Lledias, Javier
Belhassen-García, Moncef
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Vega-Rodríguez, Víctor José [0000-0001-9294-564X]
Muñoz-Bellido, Juan Luis [0000-0002-5981-8785]
Muro, Antonio [0000-0003-0244-4740]
Belhassen-García, Moncef [0000-0002-2230-1256]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
topic Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
description Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997–1998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence/association significantly increased case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/280448
url http://hdl.handle.net/10261/280448
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/jof8060576
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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