The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier

The Blood-Brain Barrier (BBB) significantly impedes drug delivery to the central nervous system. Nanotechnology, especially surface-functionalized lipid nanoparticles, offers innovative approaches to overcome this barrier. However, choosing an effective functionalization strategy is challenging due...

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Autores: Vargas, Ronny, Suñé Pou, Marc, Lizano-Barrantes, Catalina, Romero Obon, Miquel, València Clua, Kevin, Narváez-Narváez, David, Suñé i Negre, Josep M. (Josep Maria), Pérez Lozano, Pilar, García Montoya, Encarna, Martinez-Martinez, Noelia, Hernández-Munain, Cristina, Suñé, Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::3c2486a173321ca7eb4bffcbb5a9fba0
Acceso en línea:https://hdl.handle.net/2445/229019
Access Level:acceso abierto
Palabra clave:Cervell
Nanopartícules
Barrera hematoencefàlica
Brain
Nanoparticles
Blood-brain barrier
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spelling The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-BarrierVargas, RonnySuñé Pou, MarcLizano-Barrantes, CatalinaRomero Obon, Miquel València Clua, KevinNarváez-Narváez, DavidSuñé i Negre, Josep M. (Josep Maria)Pérez Lozano, PilarGarcía Montoya, EncarnaMartinez-Martinez, NoeliaHernández-Munain, CristinaSuñé, CarlosCervellNanopartículesBarrera hematoencefàlicaBrainNanoparticlesBlood-brain barrierThe Blood-Brain Barrier (BBB) significantly impedes drug delivery to the central nervous system. Nanotechnology, especially surface-functionalized lipid nanoparticles, offers innovative approaches to overcome this barrier. However, choosing an effective functionalization strategy is challenging due to the lack of detailed comparative analysis in current literature. Our systematic review examined various functionalization strategies and their impact on BBB permeability from 2041 identified articles, of which 80 were included for data extraction. Peptides were the most common modification (18) followed by mixed strategies (12) proteins (9), antibodies (7), and other strategies (8). Interestingly, 26 studies showed BBB penetration with unmodified or modified nanoparticles using commonly applied strategies such as PEGylation or surfactant addition. Statistical analysis across 42 studies showed correlation between higher in vivo permeation improvements and nanoparticle type, size, and functionalization category. The highest ratios were found for nanostructured lipid carriers or biomimetic systems, in studies with particle sizes under 150 nm, and in those applying mixed functionalization strategies. The interstudy heterogeneity we observed highlights the importance of adopting standardized evaluation protocols to enhance comparability. Our systematic review aims to provide a comparative insight and identify future research directions in the development of more effective lipid nanoparticle systems for drug delivery to the brain to help improve the treatment of neurological and psychiatric disorders and brain tumours.Elsevier B.V.2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/229019Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2024.124686International Journal of Pharmaceutics, 2024https://doi.org/10.1016/j.ijpharm.2024.124686cc-by-nc-nd (c) Ronny Vargas, et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:ubarcelona__::3c2486a173321ca7eb4bffcbb5a9fba02026-05-27T06:46:51Z
dc.title.none.fl_str_mv The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
title The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
spellingShingle The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
Vargas, Ronny
Cervell
Nanopartícules
Barrera hematoencefàlica
Brain
Nanoparticles
Blood-brain barrier
title_short The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
title_full The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
title_fullStr The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
title_full_unstemmed The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
title_sort The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
dc.creator.none.fl_str_mv Vargas, Ronny
Suñé Pou, Marc
Lizano-Barrantes, Catalina
Romero Obon, Miquel
València Clua, Kevin
Narváez-Narváez, David
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
García Montoya, Encarna
Martinez-Martinez, Noelia
Hernández-Munain, Cristina
Suñé, Carlos
author Vargas, Ronny
author_facet Vargas, Ronny
Suñé Pou, Marc
Lizano-Barrantes, Catalina
Romero Obon, Miquel
València Clua, Kevin
Narváez-Narváez, David
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
García Montoya, Encarna
Martinez-Martinez, Noelia
Hernández-Munain, Cristina
Suñé, Carlos
author_role author
author2 Suñé Pou, Marc
Lizano-Barrantes, Catalina
Romero Obon, Miquel
València Clua, Kevin
Narváez-Narváez, David
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
García Montoya, Encarna
Martinez-Martinez, Noelia
Hernández-Munain, Cristina
Suñé, Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cervell
Nanopartícules
Barrera hematoencefàlica
Brain
Nanoparticles
Blood-brain barrier
topic Cervell
Nanopartícules
Barrera hematoencefàlica
Brain
Nanoparticles
Blood-brain barrier
description The Blood-Brain Barrier (BBB) significantly impedes drug delivery to the central nervous system. Nanotechnology, especially surface-functionalized lipid nanoparticles, offers innovative approaches to overcome this barrier. However, choosing an effective functionalization strategy is challenging due to the lack of detailed comparative analysis in current literature. Our systematic review examined various functionalization strategies and their impact on BBB permeability from 2041 identified articles, of which 80 were included for data extraction. Peptides were the most common modification (18) followed by mixed strategies (12) proteins (9), antibodies (7), and other strategies (8). Interestingly, 26 studies showed BBB penetration with unmodified or modified nanoparticles using commonly applied strategies such as PEGylation or surfactant addition. Statistical analysis across 42 studies showed correlation between higher in vivo permeation improvements and nanoparticle type, size, and functionalization category. The highest ratios were found for nanostructured lipid carriers or biomimetic systems, in studies with particle sizes under 150 nm, and in those applying mixed functionalization strategies. The interstudy heterogeneity we observed highlights the importance of adopting standardized evaluation protocols to enhance comparability. Our systematic review aims to provide a comparative insight and identify future research directions in the development of more effective lipid nanoparticle systems for drug delivery to the brain to help improve the treatment of neurological and psychiatric disorders and brain tumours.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/229019
url https://hdl.handle.net/2445/229019
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2024.124686
International Journal of Pharmaceutics, 2024
https://doi.org/10.1016/j.ijpharm.2024.124686
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Ronny Vargas, et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Ronny Vargas, et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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