Prenatal exposure to organochlorine compounds and lung function during childhood
Introduction: Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function. We assessed the association between prenatal exposure to OCs and lung function during chi...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/43360 |
| Acceso en línea: | http://hdl.handle.net/10230/43360 http://dx.doi.org/10.1016/j.envint.2019.105049 |
| Access Level: | acceso abierto |
| Palabra clave: | Birth cohort Children Dichlorodiphenyldichloroethylene Lung function Organochlorine compounds Prenatal exposure |
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Prenatal exposure to organochlorine compounds and lung function during childhood |
| title |
Prenatal exposure to organochlorine compounds and lung function during childhood |
| spellingShingle |
Prenatal exposure to organochlorine compounds and lung function during childhood Abellan, Alicia Birth cohort Children Dichlorodiphenyldichloroethylene Lung function Organochlorine compounds Prenatal exposure |
| title_short |
Prenatal exposure to organochlorine compounds and lung function during childhood |
| title_full |
Prenatal exposure to organochlorine compounds and lung function during childhood |
| title_fullStr |
Prenatal exposure to organochlorine compounds and lung function during childhood |
| title_full_unstemmed |
Prenatal exposure to organochlorine compounds and lung function during childhood |
| title_sort |
Prenatal exposure to organochlorine compounds and lung function during childhood |
| dc.creator.none.fl_str_mv |
Abellan, Alicia Sunyer Deu, Jordi García Esteban, Raquel Basterrechea, Mikel Duarte Salles, Talita, 1985- Ferrero, Amparo García Aymerich, Judith Gascon Merlos, Mireia, 1984- Grimalt Obrador, Joan Lopez-Espinosa, Maria-José Zabaleta, Carlos Vrijheid, Martine Casas Sanahuja, Maribel |
| author |
Abellan, Alicia |
| author_facet |
Abellan, Alicia Sunyer Deu, Jordi García Esteban, Raquel Basterrechea, Mikel Duarte Salles, Talita, 1985- Ferrero, Amparo García Aymerich, Judith Gascon Merlos, Mireia, 1984- Grimalt Obrador, Joan Lopez-Espinosa, Maria-José Zabaleta, Carlos Vrijheid, Martine Casas Sanahuja, Maribel |
| author_role |
author |
| author2 |
Sunyer Deu, Jordi García Esteban, Raquel Basterrechea, Mikel Duarte Salles, Talita, 1985- Ferrero, Amparo García Aymerich, Judith Gascon Merlos, Mireia, 1984- Grimalt Obrador, Joan Lopez-Espinosa, Maria-José Zabaleta, Carlos Vrijheid, Martine Casas Sanahuja, Maribel |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Birth cohort Children Dichlorodiphenyldichloroethylene Lung function Organochlorine compounds Prenatal exposure |
| topic |
Birth cohort Children Dichlorodiphenyldichloroethylene Lung function Organochlorine compounds Prenatal exposure |
| description |
Introduction: Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function. We assessed the association between prenatal exposure to OCs and lung function during childhood. Methods: We included 1308 mother-child pairs enrolled in a prospective cohort study. Prenatal concentrations of p,p′-dichlorodiphenyltrichloroethane [p,p′-DDT], p,p′-dichlorodiphenyldichloroethylene [p,p′-DDE], hexachlorobenzene [HCB], and seven polychlorinated biphenyls [PCBs] were measured in cord blood. Spirometry was performed in the offspring at ages 4 (n = 636) and 7 years (n = 1192). Results: More than 80% of samples presented quantifiable levels of p,p′-DDE, HCB, PCB-138, PCB-153, and PCB-180; p,p′-DDE was the compound with the highest median concentrations. At 4 years, prenatal p,p′-DDE exposure was associated with a decrease in forced expiratory volume in 1 s (FEV1) in all quartiles of exposure (e.g., third quartile [0.23–0.34 ng/mL]: β for FEV1 −53.61 mL, 95% CI −89.87, −17.35, vs. the lowest). Prenatal p,p′-DDE levels also decreased forced vital capacity (FVC) and FEV1/FVC, but associations did not reach statistical significance in most exposure quartiles. At 7 years, p,p′-DDE was associated with a decrease in FVC and FEV1 in only the second quartile of exposure (e.g. β for FEV1 −36.96 mL, 95% CI −66.22, −7.70, vs. the lowest). Prenatal exposure to HCB was associated with decreased FVC and FEV1, but in only the second quartile and at 7 years (e.g. [0.07–0.14 ng/mL]: β for FEV1 −25.79 mL, 95% CI −55.98, 4.39, vs. the lowest). PCBs were not consistently associated with lung function. Conclusion: Prenatal exposure to p,p′-DDE may decrease lung function during childhood, especially FEV1 and at medium levels of exposure. Further and deeper knowledge on the impact of environmental chemicals during pregnancy on lung development is needed. |
| publishDate |
2019 |
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2019 2020 2020 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/43360 http://dx.doi.org/10.1016/j.envint.2019.105049 |
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http://hdl.handle.net/10230/43360 http://dx.doi.org/10.1016/j.envint.2019.105049 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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Environment International. 2019;131:105049 info:eu-repo/grantAgreement/EC/FP7/261357 info:eu-repo/grantAgreement/EC/FP7/282957 |
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http://creativecommons.org/licenses/BY/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/BY/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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Prenatal exposure to organochlorine compounds and lung function during childhoodAbellan, AliciaSunyer Deu, JordiGarcía Esteban, RaquelBasterrechea, MikelDuarte Salles, Talita, 1985-Ferrero, AmparoGarcía Aymerich, JudithGascon Merlos, Mireia, 1984-Grimalt Obrador, JoanLopez-Espinosa, Maria-JoséZabaleta, CarlosVrijheid, MartineCasas Sanahuja, MaribelBirth cohortChildrenDichlorodiphenyldichloroethyleneLung functionOrganochlorine compoundsPrenatal exposureIntroduction: Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function. We assessed the association between prenatal exposure to OCs and lung function during childhood. Methods: We included 1308 mother-child pairs enrolled in a prospective cohort study. Prenatal concentrations of p,p′-dichlorodiphenyltrichloroethane [p,p′-DDT], p,p′-dichlorodiphenyldichloroethylene [p,p′-DDE], hexachlorobenzene [HCB], and seven polychlorinated biphenyls [PCBs] were measured in cord blood. Spirometry was performed in the offspring at ages 4 (n = 636) and 7 years (n = 1192). Results: More than 80% of samples presented quantifiable levels of p,p′-DDE, HCB, PCB-138, PCB-153, and PCB-180; p,p′-DDE was the compound with the highest median concentrations. At 4 years, prenatal p,p′-DDE exposure was associated with a decrease in forced expiratory volume in 1 s (FEV1) in all quartiles of exposure (e.g., third quartile [0.23–0.34 ng/mL]: β for FEV1 −53.61 mL, 95% CI −89.87, −17.35, vs. the lowest). Prenatal p,p′-DDE levels also decreased forced vital capacity (FVC) and FEV1/FVC, but associations did not reach statistical significance in most exposure quartiles. At 7 years, p,p′-DDE was associated with a decrease in FVC and FEV1 in only the second quartile of exposure (e.g. β for FEV1 −36.96 mL, 95% CI −66.22, −7.70, vs. the lowest). Prenatal exposure to HCB was associated with decreased FVC and FEV1, but in only the second quartile and at 7 years (e.g. [0.07–0.14 ng/mL]: β for FEV1 −25.79 mL, 95% CI −55.98, 4.39, vs. the lowest). PCBs were not consistently associated with lung function. Conclusion: Prenatal exposure to p,p′-DDE may decrease lung function during childhood, especially FEV1 and at medium levels of exposure. Further and deeper knowledge on the impact of environmental chemicals during pregnancy on lung development is needed.Gipuzkoa: This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867 and FIS-PI09/00090), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). Sabadell: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; CP16/00128), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR 2009 SGR 501, Fundació La marató de TV3 (090430), EU Commission (261357). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Valencia: This study was funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Instituto de Salud Carlos III (G03/176; FIS-FEDER: PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/0663; Miguel Servet-FEDER CP11/00178, CP15/00025, and MSII16/00051), Alicia Koplowitz Foundation 2017, and Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249).Elsevier202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43360http://dx.doi.org/10.1016/j.envint.2019.105049reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnvironment International. 2019;131:105049info:eu-repo/grantAgreement/EC/FP7/261357info:eu-repo/grantAgreement/EC/FP7/282957© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).http://creativecommons.org/licenses/BY/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/433602026-06-12T07:21:37Z |
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