Ionizing radiation biomarkers in epidemiological studies - An update

Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mG...

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Autores: Hall, Janet, Jeggo, Penny A., West, Catharine, Gomolka, Maria, Quintens, Roel, Badie, Christophe, Laurent, Olivier, Aerts, Ann, Anastasov, Nataša, Azimzadeh, Omid, Azizova, Tamara, Baatout, Sarah, Baselet, Bjorn, Benotmane, Mohammed A., Blanchardon, Eric, Guéguen, Yann, Haghdoost, Siamak, Harms-Ringhdahl, Mats, Hess, Julia, Kreuzer, Michaela, Laurier, Dominique, Macaeva, Ellina, Manning, Grain, Pernot, Eileen, Ravanat, Jean-Luc, Sabatier, Laure, Tack, Karine, Tapio, Soile, Zitzelsberger, Horst, Cardis, Elisabeth
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/34940
Acceso en línea:http://hdl.handle.net/10230/34940
http://dx.doi.org/10.1016/j.mrrev.2017.01.001
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Radiació ionitzant
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spelling Ionizing radiation biomarkers in epidemiological studies - An updateHall, JanetJeggo, Penny A.West, CatharineGomolka, MariaQuintens, RoelBadie, ChristopheLaurent, OlivierAerts, AnnAnastasov, NatašaAzimzadeh, OmidAzizova, TamaraBaatout, SarahBaselet, BjornBenotmane, Mohammed A.Blanchardon, EricGuéguen, YannHaghdoost, SiamakHarms-Ringhdahl, MatsHess, JuliaKreuzer, MichaelaLaurier, DominiqueMacaeva, EllinaManning, GrainPernot, EileenRavanat, Jean-LucSabatier, LaureTack, KarineTapio, SoileZitzelsberger, HorstCardis, ElisabethMarcadors bioquímicsRadiació ionitzantRecent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30-60mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted. One biomarker identified in the final stages of development and as a priority for further research is radiation specific mRNA transcript profiles.Research in many of the authors’ laboratories has in-part been supported by the EU FP7 (Grant Number 249689) for the Network of Excellence DoReMi (Low Dose Research towards Multidisciplinary Integration)Elsevier201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34940http://dx.doi.org/10.1016/j.mrrev.2017.01.001reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésMutation Research. 2017 Jan - Mar;771:59-84info:eu-repo/grantAgreement/EC/FP7/249689© Elsevier http://dx.doi.org/10.1016/j.mrrev.2017.01.001info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/349402026-06-12T07:21:37Z
dc.title.none.fl_str_mv Ionizing radiation biomarkers in epidemiological studies - An update
title Ionizing radiation biomarkers in epidemiological studies - An update
spellingShingle Ionizing radiation biomarkers in epidemiological studies - An update
Hall, Janet
Marcadors bioquímics
Radiació ionitzant
title_short Ionizing radiation biomarkers in epidemiological studies - An update
title_full Ionizing radiation biomarkers in epidemiological studies - An update
title_fullStr Ionizing radiation biomarkers in epidemiological studies - An update
title_full_unstemmed Ionizing radiation biomarkers in epidemiological studies - An update
title_sort Ionizing radiation biomarkers in epidemiological studies - An update
dc.creator.none.fl_str_mv Hall, Janet
Jeggo, Penny A.
West, Catharine
Gomolka, Maria
Quintens, Roel
Badie, Christophe
Laurent, Olivier
Aerts, Ann
Anastasov, Nataša
Azimzadeh, Omid
Azizova, Tamara
Baatout, Sarah
Baselet, Bjorn
Benotmane, Mohammed A.
Blanchardon, Eric
Guéguen, Yann
Haghdoost, Siamak
Harms-Ringhdahl, Mats
Hess, Julia
Kreuzer, Michaela
Laurier, Dominique
Macaeva, Ellina
Manning, Grain
Pernot, Eileen
Ravanat, Jean-Luc
Sabatier, Laure
Tack, Karine
Tapio, Soile
Zitzelsberger, Horst
Cardis, Elisabeth
author Hall, Janet
author_facet Hall, Janet
Jeggo, Penny A.
West, Catharine
Gomolka, Maria
Quintens, Roel
Badie, Christophe
Laurent, Olivier
Aerts, Ann
Anastasov, Nataša
Azimzadeh, Omid
Azizova, Tamara
Baatout, Sarah
Baselet, Bjorn
Benotmane, Mohammed A.
Blanchardon, Eric
Guéguen, Yann
Haghdoost, Siamak
Harms-Ringhdahl, Mats
Hess, Julia
Kreuzer, Michaela
Laurier, Dominique
Macaeva, Ellina
Manning, Grain
Pernot, Eileen
Ravanat, Jean-Luc
Sabatier, Laure
Tack, Karine
Tapio, Soile
Zitzelsberger, Horst
Cardis, Elisabeth
author_role author
author2 Jeggo, Penny A.
West, Catharine
Gomolka, Maria
Quintens, Roel
Badie, Christophe
Laurent, Olivier
Aerts, Ann
Anastasov, Nataša
Azimzadeh, Omid
Azizova, Tamara
Baatout, Sarah
Baselet, Bjorn
Benotmane, Mohammed A.
Blanchardon, Eric
Guéguen, Yann
Haghdoost, Siamak
Harms-Ringhdahl, Mats
Hess, Julia
Kreuzer, Michaela
Laurier, Dominique
Macaeva, Ellina
Manning, Grain
Pernot, Eileen
Ravanat, Jean-Luc
Sabatier, Laure
Tack, Karine
Tapio, Soile
Zitzelsberger, Horst
Cardis, Elisabeth
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Radiació ionitzant
topic Marcadors bioquímics
Radiació ionitzant
description Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30-60mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted. One biomarker identified in the final stages of development and as a priority for further research is radiation specific mRNA transcript profiles.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34940
http://dx.doi.org/10.1016/j.mrrev.2017.01.001
url http://hdl.handle.net/10230/34940
http://dx.doi.org/10.1016/j.mrrev.2017.01.001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Mutation Research. 2017 Jan - Mar;771:59-84
info:eu-repo/grantAgreement/EC/FP7/249689
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.mrrev.2017.01.001
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.mrrev.2017.01.001
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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