Anthocyanin metabolites in human urine after the intake of new functional beverages

Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consum...

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Detalles Bibliográficos
Autores: Agulló, Vicente, Villaño Valencia, Débora, García-Viguera, Cristina, Domínguez-Perles, Raúl
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/47745
Acceso en línea:https://hdl.handle.net/2454/47745
Access Level:acceso abierto
Palabra clave:Dietary intervention
Maqui
Juice
Anthocyanins
Bioavailability
UHPLC-ESI-QqQ-MS/MS
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spelling Anthocyanin metabolites in human urine after the intake of new functional beveragesAgulló, VicenteVillaño Valencia, DéboraGarcía-Viguera, CristinaDomínguez-Perles, RaúlDietary interventionMaquiJuiceAnthocyaninsBioavailabilityUHPLC-ESI-QqQ-MS/MSSugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases.This research was funded by the Spanish MINECO, grant number AGL2016-75332-C2-1-R and AGL-2016-75332-C2-2-R. VA was funded by a FPI grant (BES-2017-079754) of the Spanish MINECO. The APC was funded by the projects AGL2016-75332-C2-1-R.MDPIAgronomía, Biotecnología y AlimentaciónAgronomia, Bioteknologia eta ElikaduraInstitute on Innovation and Sustainable Development in Food Chain - ISFOOD2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/47745reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/MINECO//AGL2016-75332-C2-1-Rinfo:eu-repo/grantAgreement/MINECO//AGL2016-75332-C2-2-R© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/477452026-06-17T12:41:47Z
dc.title.none.fl_str_mv Anthocyanin metabolites in human urine after the intake of new functional beverages
title Anthocyanin metabolites in human urine after the intake of new functional beverages
spellingShingle Anthocyanin metabolites in human urine after the intake of new functional beverages
Agulló, Vicente
Dietary intervention
Maqui
Juice
Anthocyanins
Bioavailability
UHPLC-ESI-QqQ-MS/MS
title_short Anthocyanin metabolites in human urine after the intake of new functional beverages
title_full Anthocyanin metabolites in human urine after the intake of new functional beverages
title_fullStr Anthocyanin metabolites in human urine after the intake of new functional beverages
title_full_unstemmed Anthocyanin metabolites in human urine after the intake of new functional beverages
title_sort Anthocyanin metabolites in human urine after the intake of new functional beverages
dc.creator.none.fl_str_mv Agulló, Vicente
Villaño Valencia, Débora
García-Viguera, Cristina
Domínguez-Perles, Raúl
author Agulló, Vicente
author_facet Agulló, Vicente
Villaño Valencia, Débora
García-Viguera, Cristina
Domínguez-Perles, Raúl
author_role author
author2 Villaño Valencia, Débora
García-Viguera, Cristina
Domínguez-Perles, Raúl
author2_role author
author
author
dc.contributor.none.fl_str_mv Agronomía, Biotecnología y Alimentación
Agronomia, Bioteknologia eta Elikadura
Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
dc.subject.none.fl_str_mv Dietary intervention
Maqui
Juice
Anthocyanins
Bioavailability
UHPLC-ESI-QqQ-MS/MS
topic Dietary intervention
Maqui
Juice
Anthocyanins
Bioavailability
UHPLC-ESI-QqQ-MS/MS
description Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/47745
url https://hdl.handle.net/2454/47745
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO//AGL2016-75332-C2-1-R
info:eu-repo/grantAgreement/MINECO//AGL2016-75332-C2-2-R
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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