The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
The Blood-Brain Barrier (BBB) significantly impedes drug delivery to the central nervous system. Nanotechnology, especially surface-functionalized lipid nanoparticles, offers innovative approaches to overcome this barrier. However, choosing an effective functionalization strategy is challenging due...
| Autores: | , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:dnet:recercat____::eb95ed7edea47b5177474e1b5460d9fe |
| Acesso em linha: | https://hdl.handle.net/2445/229019 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cervell Nanopartícules Barrera hematoencefàlica Brain Nanoparticles Blood-brain barrier |
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The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-BarrierVargas, RonnySuñé Pou, MarcLizano-Barrantes, CatalinaRomero Obon, MiquelValència Clua, KevinNarváez-Narváez, DavidSuñé i Negre, Josep M. (Josep Maria)Pérez Lozano, PilarGarcía Montoya, EncarnaMartinez-Martinez, NoeliaHernández-Munain, CristinaSuñé, CarlosCervellNanopartículesBarrera hematoencefàlicaBrainNanoparticlesBlood-brain barrierThe Blood-Brain Barrier (BBB) significantly impedes drug delivery to the central nervous system. Nanotechnology, especially surface-functionalized lipid nanoparticles, offers innovative approaches to overcome this barrier. However, choosing an effective functionalization strategy is challenging due to the lack of detailed comparative analysis in current literature. Our systematic review examined various functionalization strategies and their impact on BBB permeability from 2041 identified articles, of which 80 were included for data extraction. Peptides were the most common modification (18) followed by mixed strategies (12) proteins (9), antibodies (7), and other strategies (8). Interestingly, 26 studies showed BBB penetration with unmodified or modified nanoparticles using commonly applied strategies such as PEGylation or surfactant addition. Statistical analysis across 42 studies showed correlation between higher in vivo permeation improvements and nanoparticle type, size, and functionalization category. The highest ratios were found for nanostructured lipid carriers or biomimetic systems, in studies with particle sizes under 150 nm, and in those applying mixed functionalization strategies. The interstudy heterogeneity we observed highlights the importance of adopting standardized evaluation protocols to enhance comparability. Our systematic review aims to provide a comparative insight and identify future research directions in the development of more effective lipid nanoparticle systems for drug delivery to the brain to help improve the treatment of neurological and psychiatric disorders and brain tumours.Elsevier B.V.2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion32 p.application/pdfhttps://hdl.handle.net/2445/229019Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2024.124686International Journal of Pharmaceutics, 2024https://doi.org/10.1016/j.ijpharm.2024.124686cc-by-nc-nd (c) Ronny Vargas, et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::eb95ed7edea47b5177474e1b5460d9fe2026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier |
| title |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier |
| spellingShingle |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier Vargas, Ronny Cervell Nanopartícules Barrera hematoencefàlica Brain Nanoparticles Blood-brain barrier |
| title_short |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier |
| title_full |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier |
| title_fullStr |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier |
| title_full_unstemmed |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier |
| title_sort |
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier |
| dc.creator.none.fl_str_mv |
Vargas, Ronny Suñé Pou, Marc Lizano-Barrantes, Catalina Romero Obon, Miquel València Clua, Kevin Narváez-Narváez, David Suñé i Negre, Josep M. (Josep Maria) Pérez Lozano, Pilar García Montoya, Encarna Martinez-Martinez, Noelia Hernández-Munain, Cristina Suñé, Carlos |
| author |
Vargas, Ronny |
| author_facet |
Vargas, Ronny Suñé Pou, Marc Lizano-Barrantes, Catalina Romero Obon, Miquel València Clua, Kevin Narváez-Narváez, David Suñé i Negre, Josep M. (Josep Maria) Pérez Lozano, Pilar García Montoya, Encarna Martinez-Martinez, Noelia Hernández-Munain, Cristina Suñé, Carlos |
| author_role |
author |
| author2 |
Suñé Pou, Marc Lizano-Barrantes, Catalina Romero Obon, Miquel València Clua, Kevin Narváez-Narváez, David Suñé i Negre, Josep M. (Josep Maria) Pérez Lozano, Pilar García Montoya, Encarna Martinez-Martinez, Noelia Hernández-Munain, Cristina Suñé, Carlos |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cervell Nanopartícules Barrera hematoencefàlica Brain Nanoparticles Blood-brain barrier |
| topic |
Cervell Nanopartícules Barrera hematoencefàlica Brain Nanoparticles Blood-brain barrier |
| description |
The Blood-Brain Barrier (BBB) significantly impedes drug delivery to the central nervous system. Nanotechnology, especially surface-functionalized lipid nanoparticles, offers innovative approaches to overcome this barrier. However, choosing an effective functionalization strategy is challenging due to the lack of detailed comparative analysis in current literature. Our systematic review examined various functionalization strategies and their impact on BBB permeability from 2041 identified articles, of which 80 were included for data extraction. Peptides were the most common modification (18) followed by mixed strategies (12) proteins (9), antibodies (7), and other strategies (8). Interestingly, 26 studies showed BBB penetration with unmodified or modified nanoparticles using commonly applied strategies such as PEGylation or surfactant addition. Statistical analysis across 42 studies showed correlation between higher in vivo permeation improvements and nanoparticle type, size, and functionalization category. The highest ratios were found for nanostructured lipid carriers or biomimetic systems, in studies with particle sizes under 150 nm, and in those applying mixed functionalization strategies. The interstudy heterogeneity we observed highlights the importance of adopting standardized evaluation protocols to enhance comparability. Our systematic review aims to provide a comparative insight and identify future research directions in the development of more effective lipid nanoparticle systems for drug delivery to the brain to help improve the treatment of neurological and psychiatric disorders and brain tumours. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2026 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/229019 |
| url |
https://hdl.handle.net/2445/229019 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2024.124686 International Journal of Pharmaceutics, 2024 https://doi.org/10.1016/j.ijpharm.2024.124686 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd (c) Ronny Vargas, et al., 2024 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by-nc-nd (c) Ronny Vargas, et al., 2024 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
32 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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