Cocoa diet and antibody immune response in preclinical studies

The ability of cocoa to interact with the immune system in vitro and in vivo has been described. In the latter context, a cocoa-enriched diet in healthy rats was able to modify the immune system's functionality. This fact could be observed in the composition and functionality of lymphoid tissue...

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Autores: Camps i Bossacoma, Mariona, Massot Cladera, Malen, Abril Gil, Maria del Mar, Franch i Masferrer, Àngels, Pérez-Cano, Francisco J., Castell, Margarida
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124529
Acceso en línea:https://hdl.handle.net/2445/124529
Access Level:acceso abierto
Palabra clave:Dieta
Cacau
Sistema immunològic
Diet
Cocoa
Immune system
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spelling Cocoa diet and antibody immune response in preclinical studiesCamps i Bossacoma, MarionaMassot Cladera, MalenAbril Gil, Maria del MarFranch i Masferrer, ÀngelsPérez-Cano, Francisco J.Castell, MargaridaDietaCacauSistema immunològicDietCocoaImmune systemThe ability of cocoa to interact with the immune system in vitro and in vivo has been described. In the latter context, a cocoa-enriched diet in healthy rats was able to modify the immune system's functionality. This fact could be observed in the composition and functionality of lymphoid tissues, such as the thymus, spleen, and lymph nodes. Consequently, immune effector mechanisms, such as antibody synthesis, were modified. A cocoa-enriched diet in young rats was able to attenuate the serum levels of immunoglobulin (Ig) G, IgM, and IgA and also the intestinal IgM and IgA secretion. Moreover, in immunized rats, the intake of cocoa decreased specific IgG1, IgG2a, IgG2c, and IgM concentrations in serum. This immune-regulator potential was then tested in disease models in which antibodies play a pathogenic role. A cocoa-enriched diet was able to partially prevent the synthesis of autoantibodies in a model of autoimmune arthritis in rats and was also able to protect against IgE and T helper 2-related antibody synthesis in two rat models of allergy. Likewise, a cocoa-enriched diet prevented an oral sensitization process in young rats. In this review, we will focus on the influence of cocoa on the acquired branch of the immune function. Therefore, we will focus on how a cocoa diet influences lymphocyte function both in the systemic and intestinal immune system. Likewise, its potential role in preventing some antibody-induced immune diseases is also included. Although further studies must characterize the particular cocoa components responsible for such effects and nutritional studies in humans need to be carried out, cocoa has potential as a nutraceutical agent in some hypersensitivity status.Frontiers Media2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/124529Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fnut.2017.00028Frontiers in Nutrition, 2017, vol. 4, p. 28https://doi.org/10.3389/fnut.2017.00028cc-by (c) Camps Bossacoma, Mariona et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1245292026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cocoa diet and antibody immune response in preclinical studies
title Cocoa diet and antibody immune response in preclinical studies
spellingShingle Cocoa diet and antibody immune response in preclinical studies
Camps i Bossacoma, Mariona
Dieta
Cacau
Sistema immunològic
Diet
Cocoa
Immune system
title_short Cocoa diet and antibody immune response in preclinical studies
title_full Cocoa diet and antibody immune response in preclinical studies
title_fullStr Cocoa diet and antibody immune response in preclinical studies
title_full_unstemmed Cocoa diet and antibody immune response in preclinical studies
title_sort Cocoa diet and antibody immune response in preclinical studies
dc.creator.none.fl_str_mv Camps i Bossacoma, Mariona
Massot Cladera, Malen
Abril Gil, Maria del Mar
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author Camps i Bossacoma, Mariona
author_facet Camps i Bossacoma, Mariona
Massot Cladera, Malen
Abril Gil, Maria del Mar
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author_role author
author2 Massot Cladera, Malen
Abril Gil, Maria del Mar
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Dieta
Cacau
Sistema immunològic
Diet
Cocoa
Immune system
topic Dieta
Cacau
Sistema immunològic
Diet
Cocoa
Immune system
description The ability of cocoa to interact with the immune system in vitro and in vivo has been described. In the latter context, a cocoa-enriched diet in healthy rats was able to modify the immune system's functionality. This fact could be observed in the composition and functionality of lymphoid tissues, such as the thymus, spleen, and lymph nodes. Consequently, immune effector mechanisms, such as antibody synthesis, were modified. A cocoa-enriched diet in young rats was able to attenuate the serum levels of immunoglobulin (Ig) G, IgM, and IgA and also the intestinal IgM and IgA secretion. Moreover, in immunized rats, the intake of cocoa decreased specific IgG1, IgG2a, IgG2c, and IgM concentrations in serum. This immune-regulator potential was then tested in disease models in which antibodies play a pathogenic role. A cocoa-enriched diet was able to partially prevent the synthesis of autoantibodies in a model of autoimmune arthritis in rats and was also able to protect against IgE and T helper 2-related antibody synthesis in two rat models of allergy. Likewise, a cocoa-enriched diet prevented an oral sensitization process in young rats. In this review, we will focus on the influence of cocoa on the acquired branch of the immune function. Therefore, we will focus on how a cocoa diet influences lymphocyte function both in the systemic and intestinal immune system. Likewise, its potential role in preventing some antibody-induced immune diseases is also included. Although further studies must characterize the particular cocoa components responsible for such effects and nutritional studies in humans need to be carried out, cocoa has potential as a nutraceutical agent in some hypersensitivity status.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124529
url https://hdl.handle.net/2445/124529
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnut.2017.00028
Frontiers in Nutrition, 2017, vol. 4, p. 28
https://doi.org/10.3389/fnut.2017.00028
dc.rights.none.fl_str_mv cc-by (c) Camps Bossacoma, Mariona et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Camps Bossacoma, Mariona et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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