Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica

Antimicrobial resistance (AMR) is a global health concern, with natural ecosystems acting as reservoirs for resistant bacteria. We assessed AMR in Escherichia coli isolated from two wild sloth species in Costa Rica. E. coli from two-toed sloths (Choloepus hoffmanni), a species with greater mobility...

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Autores: Calvo Fernández, Cristina, Dolcet Negre, Marta M., Martín-Maldonado Jiménez, Bárbara, Pulido Vadillo, Mario, Montero, Natalia, Such, Roger, Gacía Vila, Encarnación, Delgado Blas, Jose F., González Zorn, Bruno
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/16249
Acceso en línea:https://hdl.handle.net/11268/16249
Access Level:acceso abierto
Palabra clave:Conservación de la fauna y flora silvestres
Costa Rica
Ecología
Goal 3: Ensure healthy lives and promote well-being for all at all ages
Goal 4: Quality education
Goal 13: Take urgent action to combat climate change and its impacts
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spelling Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa RicaCalvo Fernández, CristinaDolcet Negre, Marta M.Martín-Maldonado Jiménez, BárbaraPulido Vadillo, MarioMontero, NataliaSuch, RogerGacía Vila, EncarnaciónDelgado Blas, Jose F.González Zorn, BrunoConservación de la fauna y flora silvestresCosta RicaEcologíaGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 4: Quality educationGoal 13: Take urgent action to combat climate change and its impactsAntimicrobial resistance (AMR) is a global health concern, with natural ecosystems acting as reservoirs for resistant bacteria. We assessed AMR in Escherichia coli isolated from two wild sloth species in Costa Rica. E. coli from two-toed sloths (Choloepus hoffmanni), a species with greater mobility and a broader diet, showed resistance to sulfamethoxazole (25%), tetracycline (9.4%), chloramphenicol (6.3%), ampicillin (6.3%), trimethoprim (3.1%), and ciprofloxacin (3.1%), which correlated with the presence of resistance genes (tet(A), tet(B), blaTEM-1B, aph(3”)-Id, aph(6)-Id, sul2, qnrS1, floR and dfrA8). E. coli from three-toed sloths (Bradypus variegatus) showed 40% resistance to sulfamethoxazole despite no detected resistance genes, suggesting a regional effect. A significant negative correlation was found between AMR and distance to human-populated areas, highlighting anthropogenic impact on AMR spread. Notably, E. coli isolates from remote areas with no human impact indicate that some ecosystems remain unaffected. Preserving these areas is essential to protect environmental and public health20252025-09-2920252025-01-0120252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/11268/16249reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/162492026-06-11T12:41:27Z
dc.title.none.fl_str_mv Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
title Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
spellingShingle Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
Calvo Fernández, Cristina
Conservación de la fauna y flora silvestres
Costa Rica
Ecología
Goal 3: Ensure healthy lives and promote well-being for all at all ages
Goal 4: Quality education
Goal 13: Take urgent action to combat climate change and its impacts
title_short Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
title_full Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
title_fullStr Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
title_full_unstemmed Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
title_sort Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica
dc.creator.none.fl_str_mv Calvo Fernández, Cristina
Dolcet Negre, Marta M.
Martín-Maldonado Jiménez, Bárbara
Pulido Vadillo, Mario
Montero, Natalia
Such, Roger
Gacía Vila, Encarnación
Delgado Blas, Jose F.
González Zorn, Bruno
author Calvo Fernández, Cristina
author_facet Calvo Fernández, Cristina
Dolcet Negre, Marta M.
Martín-Maldonado Jiménez, Bárbara
Pulido Vadillo, Mario
Montero, Natalia
Such, Roger
Gacía Vila, Encarnación
Delgado Blas, Jose F.
González Zorn, Bruno
author_role author
author2 Dolcet Negre, Marta M.
Martín-Maldonado Jiménez, Bárbara
Pulido Vadillo, Mario
Montero, Natalia
Such, Roger
Gacía Vila, Encarnación
Delgado Blas, Jose F.
González Zorn, Bruno
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Conservación de la fauna y flora silvestres
Costa Rica
Ecología
Goal 3: Ensure healthy lives and promote well-being for all at all ages
Goal 4: Quality education
Goal 13: Take urgent action to combat climate change and its impacts
topic Conservación de la fauna y flora silvestres
Costa Rica
Ecología
Goal 3: Ensure healthy lives and promote well-being for all at all ages
Goal 4: Quality education
Goal 13: Take urgent action to combat climate change and its impacts
description Antimicrobial resistance (AMR) is a global health concern, with natural ecosystems acting as reservoirs for resistant bacteria. We assessed AMR in Escherichia coli isolated from two wild sloth species in Costa Rica. E. coli from two-toed sloths (Choloepus hoffmanni), a species with greater mobility and a broader diet, showed resistance to sulfamethoxazole (25%), tetracycline (9.4%), chloramphenicol (6.3%), ampicillin (6.3%), trimethoprim (3.1%), and ciprofloxacin (3.1%), which correlated with the presence of resistance genes (tet(A), tet(B), blaTEM-1B, aph(3”)-Id, aph(6)-Id, sul2, qnrS1, floR and dfrA8). E. coli from three-toed sloths (Bradypus variegatus) showed 40% resistance to sulfamethoxazole despite no detected resistance genes, suggesting a regional effect. A significant negative correlation was found between AMR and distance to human-populated areas, highlighting anthropogenic impact on AMR spread. Notably, E. coli isolates from remote areas with no human impact indicate that some ecosystems remain unaffected. Preserving these areas is essential to protect environmental and public health
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-09-29
2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11268/16249
url https://hdl.handle.net/11268/16249
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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