Solution equilibria of cytosine- and guanine-rich sequences near the promoter region of the n-myc gene that contain stable hairpins within lateral loops

Cytosine-and guanine-rich regions of DNA are capable of forming complex structures named i-motifs and G-quadruplexes, respectively. In the present study the solution equilibria at nearly physiological conditions of a 34 -bases long cytosine-rich sequence and its complementary guanin e-rich strand co...

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Bibliographic Details
Authors: Benabou Zdaou, Sanae, Ferreira Aguilera, Rubén, Aviñó Andrés, Anna, González, Carlos, Lyonnais, Sébastien, Solà Vilarrubias, Maria, Eritja i Casadellà, Ramon, Jaumot Soler, Joaquim, Gargallo Gómez, Raimundo
Format: article
Status:Versión aceptada para publicación
Publication Date:2013
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/46204
Online Access:https://hdl.handle.net/2445/46204
Access Level:Open access
Keyword:ADN
RNA
Àcids nucleics
Anàlisi multivariable
Cromatografia
DNA
Nucleic acids
Multivariate analysis
Chromatography
Description
Summary:Cytosine-and guanine-rich regions of DNA are capable of forming complex structures named i-motifs and G-quadruplexes, respectively. In the present study the solution equilibria at nearly physiological conditions of a 34 -bases long cytosine-rich sequence and its complementary guanin e-rich strand corresponding to the first intron of the n-mycgene were studied. Both sequences , not yet studied, contain a 12 - base tract capable of forming stable hairpins inside the i-motif and G-quadruplex structures, respectively ...

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