Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF
BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coro...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| Repositorio: | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| OAI Identifier: | oai:i3pt.fundanetsuite.com:p2841 |
| Acceso en línea: | https://i3pt.portalinvestigacion.com/publicaciones/2841 |
| Access Level: | acceso abierto |
| Palabra clave: | Anticoagulation Antiplatelet therapy Bleeding Mortality Stroke |
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ES_bb9c6fae07097dcdec90316de3234a74 |
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oai:i3pt.fundanetsuite.com:p2841 |
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| network_name_str |
España |
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| dc.title.none.fl_str_mv |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF |
| title |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF |
| spellingShingle |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF Verheugt, FWA Anticoagulation Antiplatelet therapy Bleeding Mortality Stroke |
| title_short |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF |
| title_full |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF |
| title_fullStr |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF |
| title_full_unstemmed |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF |
| title_sort |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF |
| dc.creator.none.fl_str_mv |
Verheugt, FWA Ambrosio, G Atar, D Bassand, JP Camm, AJ Costabel, JP Fitzmaurice, DA Illingworth, L Goldhaber, SZ Goto, S Haas, S Jansky, P Kayani, G Stepinska, J Turpie, AGG van Eickels, M Kakkar, AK Hacke, W Mantovani, LG Misselwitz, F Pieper, KS Kayani, GR Fox, KAA Gersh, BJ Luciardi, HL Gibbs, H Brodmann, M Cools, F Barrett, ACP Connolly, SJ Spyropoulos, A Eikelboom, J Corbalan, R Hu, DY Nielsen, JD Ragy, H Raatikainen, P Le Heuzey, JY Darius, H Keltai, M Kakkar, S Sawhney, JPS Agnelli, G Koretsune, Y Diaz, CJS Ten Cate, H Panchenko, E Lim, TW Jacobson, B Oh, S Vinolas, X Rosenqvist, M Steffel, J Angchaisuksiri, P Oto, A Parkhomenko, A Al Mahmeed, W Fitzmaurice, D Chen, KN Zhao, YS Zhang, HQ Chen, JY Cao, SP Wang, DW Yang, YJ Li, WH Li, H Yin, YH Tao, GZ Yang, P Chen, YM He, SH Wang, Y Fu, GS Li, X Wu, TG Cheng, XS Yan, XW Zhao, RP Chen, MS Xiong, LG Chen, P Jiao, Y Guo, Y Xue, L Yang, ZM Jadhavm, P Sarma, R Kulkarni, G Chandwani, P Pothiwala, RA Purayil, MP Chawla, K Kothiwale, VA Raghuraman, B Vijan, VM Sawhney, J Bantwal, G Khan, A Meena, R Chopada, M Abraham, S Bisne, V Vijayaraghavan, G Roy, D Durgaprasad, R Shankar, AGR Kumar, S Jain, D Bhargava, K Kumar, V Nagamalesh, UM Rajput, RK Kanamori, S Yamamoto, K Kumagai, K Katsuda, Y Yoshida, K Toyota, F Mizuno, Y Misumi, I Noguchi, H Ando, S Suetsugu, T Minamoto, M Oda, H Adachi, S Chiba, K Norita, H Tsuruta, M Koyanagi, T Yamamoto, K Ando, H Higashi, T Okada, M Azakami, S Komaki, S Kumeda, K Murayama, T Matsumura, J Oba, Y Sonoda, R Goto, K Minoda, K Haraguchi, Y Suefuji, H Miyagi, H Kato, H Nakamura, T Nakamura, T Nandate, H Zaitsu, R Fujiura, Y Yoshimura, A Numata, H Ogawa, J Kamogawa, Y Murakami, K Wakasa, Y Yamasawa, M Maekawa, H Abe, S Kihara, H Tsunoda, S Saito, K Tachibana, H Oba, I Kuwahata, T Higa, S Gushiken, M Eto, T Chibana, H Fujisawa, K Shiga, Y Sumi, H Nagatomo, T Atsuchi, Y Nagoshi, T Sanno, K Hoshino, F Yokota, N Kameko, M Tabuchi, T Ishizawa, M Fujiura, Y Ikeda, D Seto, T Iwao, T Ishioka, N Oshiro, K Tsuchida, K Hatori, Y Takeuchi, M Takezawa, H Nagano, S Iwaki, M Nakamura, Y Miyamoto, N Taguchi, T Ashida, K Yoshizawa, N Agata, J Matsukawa, S Arasaki, O Fukuoka, S Murakami, H Mishima, K Hata, Y Sakuma, I Obunai, K Takamura, I Akutsu, M Unoki, T Go, Y Ikemura, M Morii, S Marusaki, S Doi, H Tanaka, M Kusu-moto, T Kakinoki, S Ogurusu, C Murata, K Shimoyama, M Nakatsuka, M Kitami, Y Nakamura, Y Oda, H Oyama, R Ageta, M Mita, T Nagao, K Mito, T Minami, J Abe, M Fujii, M Okawa, M Fujito, T Taniguchi, T Ko, T Kubo, H Imamaki, M Akiyama, M Ueda, T Odakura, H Inagaki, M Katsube, Y Nakata, A Tomimoto, S Shibuya, M Nakano, M Ito, K Matsuta, M Ishiguro, M Minagawa, T Wada, M Mukawa, H Mizuguchi, M Okuda, F Kimura, T Taga, K Techigawara, M Igarashi, M Watanabe, H Seo, T Hiramitsu, S Hosokawa, H Hoshiai, M Hibino, M Miyagawa, K Horie, H Sugishita, N Shiga, Y Soma, A Neya, K Yoshida, T Akahane, K Adachi, S Takanaka, C Matsui, S Kanda, H Kaneko, M Nagasaka, S Taguchi, A Toru, S Saito, K Miyashita, A Sasaguri, H Nariyama, J Hatsuno, T Iwase, T Sato, K Kawai, K Kotani, T Tsuji, T Sakai, H Nishino, K Ikeda, K Maeda, K Shinozuka, T Inoue, T Kawakami, K Kitazumi, H Takagi, T Hamaoka, M Kojima, J Sasaki, A Tsuchiya, Y Bet-suyaku, T Higuchi, K Honda, M Hasegawa, K Baba, T Mineoi, K Koeda, T Hirasawa, K Kumazaki, T Nakagomi, A Otaki, E Shindo, T Hirayama, H Sugimoto, C Yamagishi, T Mizuguchi, I Sezaki, K Niwa, I Takenaka, K Iiji, O Taya, K Kitazawa, H Ueda, S Kakuda, H Ono, T Oriso, S Kamata, J Nanke, T Maeda, I Matsuura, Y Teragawa, H Maruyama, Y Takei, K Hone, H Kito, TT Asano, H Matsushita, K Nakamura, M Washizuka, T Yoshida, T Sawano, M Arima, S Arai, H Shinohara, H Takai, H Furukawa, N Ota, A Yamamoto, K Aoki, K Yamamoto, T Kasai, T Suzuki, S Suzuki, S Shibata, N Watanabe, M Nishihata, Y Arino, T Okuyama, M Wakiyama, T Kato, T Sasagawa, Y Tana, T Hayashi, Y Hirota, S Abe, Y Saito, Y Uchiyama, H Takeda, H Ono, H Tohyo, S Hanazono, N Miyajima, S Shimono, H Aoyama, T Shozawa, Y Niijima, Y Murai, O Inaba, H Nomura, K Nozoe, M Suzuki, K Furukawa, T Shiraiwa, T Ito, N Nagai, S Sato, K Nakahara, S Shimoyama, Y Ohara, N Kozuka, T Okita, H Endo, M Goto, T Hirose, M Nagata, E Nakanishi, N Mori, T Seki, S Okamoto, K Moriai, O Emura, Y Fukuda, T Date, H Kawakami, S Nagai, S Ueyama, Y Fudo, T Imaizumi, M Ogawa, T Take, S Ikeda, H Nishioka, H Sakamoto, N Ikeoka, K Wakaki, N Abe, M Doiuchi, J Kira, T Tada, M Tsuzaki, K Miura, N Fujisawa, Y Furumoto, W Suzuki, S Fujisawa, A Nakamura, R Komatsu, H Fujiki, R Kawano, S Nishizawa, K Kato, Y Azuma, J Yasui, K Amano, T Sekine, Y Honzawa, T Koshibu, Y Sakamoto, Y Seta, Y Miyaguchi, S Morishita, K Samejima, Y Sasaki, T Iseki, F Kobayashi, T Kano, H Kim, J Yamaguchi, H Takagi, Y Pearce, YO Suzuki, Y Fukui, T Nakayama, T Kanai, H Kawano, Y Ino, T Miyoshi, H Miyamoto, Y Shigekiyo, M Ono, S Okamoto, Y Ubukata, S Kodera, K Oriuchi, T Matsumoto, N Inagaki, K Iseki, A Yoshida, T Goda, T Katsuki, T Sato, A Mori, E Tsubokura, T Shudo, H Fujimoto, S Katsuya, T Furukawa, Y Hosokawa, H Narumi, J Yamamoto, K Owari, M Inakura, T Anno, T Shirakawa, K Ching, CK Foo, D Wong, K Yuyang, T Park, HN Kim, WS Lee, H Jang, SW Kim, DH Kim, J Ryu, D Shim, J Kim, DK Choi, DJ Oh, YS Cho, MC Kim, HL Jeon, HK Shin, DG Park, SW Park, HK Han, SJ Sung, JH Park, HW Nam, GB On, YK Lim, HE Kwak, J Cha, TJ Hong, TJ Park, SH Yoon, JH Kim, NH Kim, KS Jung, BC Hwang, GS Kim, CJ Rungaramsin, S Katekangplu, P Khunrong, P Bunyapipat, T Wongcharoen, W Kaewsuwanna, P Siriwattana, K Tiyanon, W Pattanaprichakul, S Likittanasombat, K Cholsaringkarl, D Boonyapisit, W Cheewatanakornkul, S Silaruks, S Hutayanon, P Chawanadelert, S Chattranukulchai, P Chatlaong, B Santanakorn, Y Kanokphatcharakun, K Mongkolwongroj, P Jai-Aue, S Komson, O Altun, A Aydinlar, A Topsakal, R Ongen, Z Acikel, S Sahin, DY Yilmaz, O Yilmaz, MB Pekdemir, H Demir, M Sucu, M Sahiner, L Ersanli, M Okuyan, E Aras, D Rolandi, F Ingaramo, AC Sambadaro, GA Caputi, VF Luciardi, H 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Fernandez, CAA Navarro, EM Alia, JJM Gonzalez, MB Oliva, MAM Sanmartin, JI Gonzalez, MJ Alvarez, MDR Melenchon, JH Vera, TR Navarro, MJ Caamano, MV Tones, MFA Gomez, GM Romo, AI Diaz, MAP Wirdby, A Linden, J Henriksson, K Elmersson, M Egilsson, A Borjesson, U Svard, G Liu, B Lindh, A Olsson, LB Gustaysson, M Andersson, L Benson, L Bothin, C Hajimirsadeghi, A Martinsson, B Ericsson, M Ohlsson, A Lindvall, H Svensson, P Thorne, K Handel, H Platonov, P Bernsten, F Timberg, I Crisby, M Karlsson, JE Andersson, A Malmqvist, L Engdahl, J Thulin, J Hot-Bjelak, A Jensen, S Stalby, P Debrunner, J Beer, JH Shah, D Rudyk, I Tseluyko, V Karpenko, O Zhurba, S Kraiz, I Parkhomenko, O Kupnovytska, I Seredyuk, N Mostovoy, Y Ushakov, O Koval, O Kovalskiy, I Svyshchenko, Y Sychov, O Stanislavchuk, M Yagensky, A Tykhonova, S Fushtey, I Murdoch, W Chauhan, N Goodwin, D Lumley, L Patel, R Saunders, P Wong, B Cameron, A Patel, N Jhittay, P Ross, A Kainth, MS Ladha, K Douglas, K Pickavance, G McDonnell, J Handscombe, L Gooding, T Wagner, H Bradshaw, C Bromham, C Jones, K Suryani, S Coates, R Sarai, B Willcock, W Sircar, S Cairns, J Gilliand, A Bilas, R Strieder, E Hutchinson, P Wakeman, A Stokes, M Kirby, G Vishwanathan, B Bird, N Evans, P Clark, M Bisatt, J Litchfield, J Fisher, E Fooks, T Kelsall, R Paul, N Alborough, E Aziz, M Ramesh, C Wilson, P Franklin, S Fairhead, S Thompson, J Chowan, H Taylor, G Tragen, D Parfitt, M Seamark, C Paul, C Richardson, M Jefferies, A Sharp, H Jones, H Giles, C Bramley, M Williams, P Aldegather, J Wetherell, S Lumb, W Evans, P Scouller, F Macey, N Rogers, S Stipp, Y West, R Pinney, P Wadeson, P Matthews, J Pandya, P Gallagher, A Railton, T Davies, E McClure, J Jacobs, M Hutton, C Thompson, R Sinha, B Butter, K Barrow, S Little, H Russell, D Choudhary, U Haq, I Ainsworth, P Jones, C Weeks, P Eden, J Gibbons, L Glencross, J MacLeod, A Poland, K Mulolland, C Warke, A Conn, P Burns, D Smith, R Kamath, R Webster, J Hodgins, I Vercoe, S Roome, P Pinnock, H Patel, J Ali, A Hart, N Davies, R De-Sousa, N Neden, C Danielsen, M Sharma, P Galloway, S Hawkins, C Oliver, R Aylward, M Pattni, M Irvine, G Ahmad, S Rothwell, C Choudhary, F Khalaque, S Short, S Peters, S Coulson, W Roberts, N Butler, A Coates, S Ward, B Jackson, D Walton, S Shepherd, D Wong, T Boon, M Deacon, M Cornelius, D Davies, S Ben Frankel Hargreaves, N Choi, H Sumner, J Myhill, T Estifanos, S Geatch, D Wilkinson, J Veale, R Forshaw, K Hirst, R Zaman, K Liley, C Wastling, R McEleny, P Beattie, A Cooke, P Wong, M Pugsley, M Dooldeniya, C Rogers, G Bennett, J Jacobs, P Muvva, R Adam, M Fox, R Thomas, N Cartwright, S Reed, R Randfield, S ACourt, C Flynn, A Halpin, A Dobson, S Lomax, L Nadaph, M Goram, J Stoddart, H Simmons, P Shewring, J Bowen-Simpkins, E Rickenbach, M Munro, I Blenkhorn, A Singh, B Astridge, P van Gaal, W Abhayaratna, W Thomson, P Lehman, R Kilian, J Coulshed, D Catanchin, A Colquhoun, D Kiat, H Eccleston, D French, J Ayres, B Blombery, P Phan, T Rogers, J O'Donnell, D Cheol, S Carroll, P Starmer, G Arstall, M Binnekamp, M Lee, A Luton, R Gupta, M Pandey, AS Cheung, S Leader, R Beaudry, P Ayala-Paredes, F Berlingieri, J Heath, J Poirier, G du Preez, M Schweitzer, B Nadeau, R Dhillon, R Hruczkowski, T Lavoie, A Parkash, R Cha, J Coutu, B MacDonald, P Ramjattan, B Bonet, J Vizel, S Angaran, P Fikry, S Mowafy, A Katta, A Tawfik, M Nawar, M Sobhy, M Abou Seif, SK Khairy, T Abd El-Aziz, A Taha, N Reda, A Elbahry, A Setiha, M El Din, MG Elkhadem, M El-Etreby, A Kettles, D Bayat, J Siebert, H Horak, A Kelfkens, Y Garda, R Pillay, T Guerra, M van Zyl, L Theron, H Murray, A Louw, R Greyling, D Mntla, P Ismail, S Ahmed, F Engelbrecht, J Maharajh, S Oosthuysen, W Loghdey, R Ueckermann, V Al Naeemi, A Yousef, G Bazargani, N Alomairi, M Maruthanayagam, R Singh, R Naguib, A Ibrahim, M Agrawal, A Nathani, M Esheiba, EM Wassef, A Gupta, R Cox, M Beach, S Duffy, P Falkowski, S Ferrick, K Franco, M Kutayli, WM Quick, A Sharma, N Wilson, V Miller, S Alberts, M Blumberg, E Canosa, R Gutowski, T Ison, R Garcia, J Mullen, P Noveck, H Rama, P Reddy, R Williams, M Nishijima, D Ferdinand, K Hague, I Mendelson, R Pitta, S Theodoro, D Treasure, C Moustafa, M Cader, C Pharr, W Oropallo, A Platt, G Gujral, J Welker, J Koura, F |
| author |
Verheugt, FWA |
| author_facet |
Verheugt, FWA Ambrosio, G Atar, D Bassand, JP Camm, AJ Costabel, JP Fitzmaurice, DA Illingworth, L Goldhaber, SZ Goto, S Haas, S Jansky, P Kayani, G Stepinska, J Turpie, AGG van Eickels, M Kakkar, AK Hacke, W Mantovani, LG Misselwitz, F Pieper, KS Kayani, GR Fox, KAA Gersh, BJ Luciardi, HL Gibbs, H Brodmann, M Cools, F Barrett, ACP Connolly, SJ Spyropoulos, A Eikelboom, J Corbalan, R Hu, DY Nielsen, JD Ragy, H Raatikainen, P Le Heuzey, JY Darius, H Keltai, M Kakkar, S Sawhney, JPS Agnelli, G Koretsune, Y Diaz, CJS Ten Cate, H Panchenko, E Lim, TW Jacobson, B Oh, S Vinolas, X Rosenqvist, M Steffel, J Angchaisuksiri, P Oto, A Parkhomenko, A Al Mahmeed, W Fitzmaurice, D Chen, KN Zhao, YS Zhang, HQ Chen, JY Cao, SP Wang, DW Yang, YJ Li, WH Li, H Yin, YH Tao, GZ Yang, P Chen, YM He, SH Wang, Y Fu, GS Li, X Wu, TG Cheng, XS Yan, XW Zhao, RP Chen, MS Xiong, LG Chen, P Jiao, Y Guo, Y Xue, L Yang, ZM Jadhavm, P Sarma, R Kulkarni, G Chandwani, P Pothiwala, RA Purayil, MP Chawla, K Kothiwale, VA Raghuraman, B Vijan, VM Sawhney, J Bantwal, G Khan, A Meena, R Chopada, M Abraham, S Bisne, V Vijayaraghavan, G Roy, D Durgaprasad, R Shankar, AGR Kumar, S Jain, D Bhargava, K Kumar, V Nagamalesh, UM Rajput, RK Kanamori, S Yamamoto, K Kumagai, K Katsuda, Y Yoshida, K Toyota, F Mizuno, Y Misumi, I Noguchi, H Ando, S Suetsugu, T Minamoto, M Oda, H Adachi, S Chiba, K Norita, H Tsuruta, M Koyanagi, T Ando, H Higashi, T Okada, M Azakami, S Komaki, S Kumeda, K Murayama, T Matsumura, J Oba, Y Sonoda, R Goto, K Minoda, K Haraguchi, Y Suefuji, H Miyagi, H Kato, H Nakamura, T Nandate, H Zaitsu, R Fujiura, Y Yoshimura, A Numata, H Ogawa, J Kamogawa, Y Murakami, K Wakasa, Y Yamasawa, M Maekawa, H Abe, S Kihara, H Tsunoda, S Saito, K Tachibana, H Oba, I Kuwahata, T Higa, S Gushiken, M Eto, T Chibana, H Fujisawa, K Shiga, Y Sumi, H Nagatomo, T Atsuchi, Y Nagoshi, T Sanno, K Hoshino, F Yokota, N Kameko, M Tabuchi, T Ishizawa, M Ikeda, D Seto, T Iwao, T Ishioka, N Oshiro, K Tsuchida, K Hatori, Y Takeuchi, M Takezawa, H Nagano, S Iwaki, M Nakamura, Y Miyamoto, N Taguchi, T Ashida, K Yoshizawa, N Agata, J Matsukawa, S Arasaki, O Fukuoka, S Murakami, H Mishima, K Hata, Y Sakuma, I Obunai, K Takamura, I Akutsu, M Unoki, T Go, Y Ikemura, M Morii, S Marusaki, S Doi, H Tanaka, M Kusu-moto, T Kakinoki, S Ogurusu, C Murata, K Shimoyama, M Nakatsuka, M Kitami, Y Oyama, R Ageta, M Mita, T Nagao, K Mito, T Minami, J Abe, M Fujii, M Okawa, M Fujito, T Taniguchi, T Ko, T Kubo, H Imamaki, M Akiyama, M Ueda, T Odakura, H Inagaki, M Katsube, Y Nakata, A Tomimoto, S Shibuya, M Nakano, M Ito, K Matsuta, M Ishiguro, M Minagawa, T Wada, M Mukawa, H Mizuguchi, M Okuda, F Kimura, T Taga, K Techigawara, M Igarashi, M Watanabe, H Seo, T Hiramitsu, S Hosokawa, H Hoshiai, M Hibino, M Miyagawa, K Horie, H Sugishita, N Soma, A Neya, K Yoshida, T Akahane, K Takanaka, C Matsui, S Kanda, H Kaneko, M Nagasaka, S Taguchi, A Toru, S Miyashita, A Sasaguri, H Nariyama, J Hatsuno, T Iwase, T Sato, K Kawai, K Kotani, T Tsuji, T Sakai, H Nishino, K Ikeda, K Maeda, K Shinozuka, T Inoue, T Kawakami, K Kitazumi, H Takagi, T Hamaoka, M Kojima, J Sasaki, A Tsuchiya, Y Bet-suyaku, T Higuchi, K Honda, M Hasegawa, K Baba, T Mineoi, K Koeda, T Hirasawa, K Kumazaki, T Nakagomi, A Otaki, E Shindo, T Hirayama, H Sugimoto, C Yamagishi, T Mizuguchi, I Sezaki, K Niwa, I Takenaka, K Iiji, O Taya, K Kitazawa, H Ueda, S Kakuda, H Ono, T Oriso, S Kamata, J Nanke, T Maeda, I Matsuura, Y Teragawa, H Maruyama, Y Takei, K Hone, H Kito, TT Asano, H Matsushita, K Nakamura, M Washizuka, T Sawano, M Arima, S Arai, H Shinohara, H Takai, H Furukawa, N Ota, A Aoki, K Yamamoto, T Kasai, T Suzuki, S Shibata, N Watanabe, M Nishihata, Y Arino, T Okuyama, M Wakiyama, T Kato, T Sasagawa, Y Tana, T Hayashi, Y Hirota, S Abe, Y Saito, Y Uchiyama, H Takeda, H Ono, H Tohyo, S Hanazono, N Miyajima, S Shimono, H Aoyama, T Shozawa, Y Niijima, Y Murai, O Inaba, H Nomura, K Nozoe, M Suzuki, K Furukawa, T Shiraiwa, T Ito, N Nagai, S 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Jang, SW Kim, DH Ryu, D Shim, J Kim, DK Choi, DJ Oh, YS Cho, MC Kim, HL Jeon, HK Shin, DG Park, SW Park, HK Han, SJ Sung, JH Park, HW Nam, GB On, YK Lim, HE Kwak, J Cha, TJ Hong, TJ Park, SH Yoon, JH Kim, NH Kim, KS Jung, BC Hwang, GS Kim, CJ Rungaramsin, S Katekangplu, P Khunrong, P Bunyapipat, T Wongcharoen, W Kaewsuwanna, P Siriwattana, K Tiyanon, W Pattanaprichakul, S Likittanasombat, K Cholsaringkarl, D Boonyapisit, W Cheewatanakornkul, S Silaruks, S Hutayanon, P Chawanadelert, S Chattranukulchai, P Chatlaong, B Santanakorn, Y Kanokphatcharakun, K Mongkolwongroj, P Jai-Aue, S Komson, O Altun, A Aydinlar, A Topsakal, R Ongen, Z Acikel, S Sahin, DY Yilmaz, O Yilmaz, MB Pekdemir, H Demir, M Sucu, M Sahiner, L Ersanli, M Okuyan, E Aras, D Rolandi, F Ingaramo, AC Sambadaro, GA Caputi, VF Luciardi, H Berman, SG Dragotto, P Kleiban, AJ Centurion, N Guerrero, RAA Di Paola, LA Dran, RD Egido, J Fosco, MJ Sinisi, VA Cartasegna, LR Vilamajo, OG Ramos, JL Sassone, S Zapata, G Conde, D 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JV Fierro, OF Briones, IR Pons, JLL Lopez, HA Ruiz, RO Brito, CGC Valenzuela, EJJRC Sanchez, RR Ruiz, AEB Ruiz, OML Nava, RA Cerda, JDM Campos, PF Gonzalez, MB Lenz, K Hagn, C Foechterle, J Drexel, H Huber, K Podczeck-Schweighofer, A Winkler, M Schneeweiss, B Gegenhuber, A Lang, W Eichinger-Hasenauer, S Kaserer, P Sykora, J Rasch, H Strohmer, B Capiau, L Vervoort, G Wollaert, B Hollanders, G Vercammen, J Faes, D Balthazar, Y Delforge, M Xhaet, O Striekwold, H Thoeng, J Hermans, K Mairesse, G Anne, W Blankoff, I Beutels, M Verstraete, S Vandergoten, P Purnode, P Godart, P Boussy, T Desfontaines, P Heyse, A Voet, J De Wolf, A Zidkova, E Spacek, R Machova, V Ludka, O Olsr, J Kotik, L Racz, B Ferkl, R Hubac, J Kotik, I Monhart, Z Burianova, H Jerabek, O Pisova, J Petrova, I Dedek, V Honkova, M Podrazil, P Reichert, P Spinar, J Novak, M Durdil, V Plocova, K Lastuvka, J Nielsen, J Husted, S Dominguez, H Hintze, U Rasmussen, S Sygehus, N Bremmelgaard, A Markenvard, J Borger, J Solgaard, J 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Vishwanathan, B Bird, N Evans, P Clark, M Bisatt, J Litchfield, J Fisher, E Fooks, T Kelsall, R Paul, N Alborough, E Aziz, M Ramesh, C Wilson, P Franklin, S Fairhead, S Thompson, J Chowan, H Taylor, G Tragen, D Parfitt, M Seamark, C Paul, C Richardson, M Jefferies, A Sharp, H Jones, H Giles, C Bramley, M Williams, P Aldegather, J Wetherell, S Lumb, W Scouller, F Macey, N Rogers, S Stipp, Y West, R Pinney, P Wadeson, P Matthews, J Pandya, P Gallagher, A Railton, T Davies, E McClure, J Jacobs, M Hutton, C Thompson, R Sinha, B Butter, K Barrow, S Little, H Russell, D Choudhary, U Haq, I Ainsworth, P Jones, C Weeks, P Eden, J Gibbons, L Glencross, J MacLeod, A Poland, K Mulolland, C Warke, A Conn, P Burns, D Smith, R Kamath, R Webster, J Hodgins, I Vercoe, S Roome, P Pinnock, H Patel, J Ali, A Hart, N Davies, R De-Sousa, N Neden, C Danielsen, M Sharma, P Galloway, S Hawkins, C Oliver, R Aylward, M Pattni, M Irvine, G Ahmad, S Rothwell, C Choudhary, F Khalaque, S Short, S Peters, S Coulson, W Roberts, N Butler, A Coates, S Ward, B Jackson, D Walton, S Shepherd, D Wong, T Boon, M Deacon, M Cornelius, D Davies, S Ben Frankel Hargreaves, N Choi, H Sumner, J Myhill, T Estifanos, S Geatch, D Wilkinson, J Veale, R Forshaw, K Hirst, R Zaman, K Liley, C Wastling, R McEleny, P Beattie, A Cooke, P Wong, M Pugsley, M Dooldeniya, C Rogers, G Bennett, J Jacobs, P Muvva, R Adam, M Fox, R Thomas, N Cartwright, S Reed, R Randfield, S ACourt, C Flynn, A Halpin, A Dobson, S Lomax, L Nadaph, M Goram, J Stoddart, H Simmons, P Shewring, J Bowen-Simpkins, E Rickenbach, M Munro, I Blenkhorn, A Singh, B Astridge, P van Gaal, W Abhayaratna, W Thomson, P Lehman, R Kilian, J Coulshed, D Catanchin, A Colquhoun, D Kiat, H Eccleston, D French, J Ayres, B Blombery, P Phan, T Rogers, J O'Donnell, D Cheol, S Carroll, P Starmer, G Arstall, M Binnekamp, M Lee, A Luton, R Gupta, M Pandey, AS Cheung, S Leader, R Beaudry, P Ayala-Paredes, F Berlingieri, J Heath, J Poirier, G du Preez, M Schweitzer, B Nadeau, R Dhillon, R Hruczkowski, T Lavoie, A Parkash, R Cha, J Coutu, B MacDonald, P Ramjattan, B Bonet, J Vizel, S Angaran, P Fikry, S Mowafy, A Katta, A Tawfik, M Nawar, M Sobhy, M Abou Seif, SK Khairy, T Abd El-Aziz, A Taha, N Reda, A Elbahry, A Setiha, M El Din, MG Elkhadem, M El-Etreby, A Kettles, D Bayat, J Siebert, H Horak, A Kelfkens, Y Garda, R Pillay, T Guerra, M van Zyl, L Theron, H Murray, A Louw, R Greyling, D Mntla, P Ismail, S Ahmed, F Engelbrecht, J Maharajh, S Oosthuysen, W Loghdey, R Ueckermann, V Al Naeemi, A Yousef, G Bazargani, N Alomairi, M Maruthanayagam, R Singh, R Naguib, A Ibrahim, M Agrawal, A Nathani, M Esheiba, EM Wassef, A Gupta, R Cox, M Beach, S Duffy, P Falkowski, S Ferrick, K Franco, M Kutayli, WM Quick, A Sharma, N Wilson, V Miller, S Alberts, M Blumberg, E Canosa, R Gutowski, T Ison, R Garcia, J Mullen, P Noveck, H Rama, P Reddy, R Williams, M Nishijima, D Ferdinand, K Hague, I Mendelson, R Pitta, S Theodoro, D Treasure, C Moustafa, M Cader, C Pharr, W Oropallo, A Platt, G Gujral, J Welker, J Koura, F |
| author_role |
author |
| author2 |
Ambrosio, G Atar, D Bassand, JP Camm, AJ Costabel, JP Fitzmaurice, DA Illingworth, L Goldhaber, SZ Goto, S Haas, S Jansky, P Kayani, G Stepinska, J Turpie, AGG van Eickels, M Kakkar, AK Hacke, W Mantovani, LG Misselwitz, F Pieper, KS Kayani, GR Fox, KAA Gersh, BJ Luciardi, HL Gibbs, H Brodmann, M Cools, F Barrett, ACP Connolly, SJ Spyropoulos, A Eikelboom, J Corbalan, R Hu, DY Nielsen, JD Ragy, H Raatikainen, P Le Heuzey, JY Darius, H Keltai, M Kakkar, S Sawhney, JPS Agnelli, G Koretsune, Y Diaz, CJS Ten Cate, H Panchenko, E Lim, TW Jacobson, B Oh, S Vinolas, X Rosenqvist, M Steffel, J Angchaisuksiri, P Oto, A Parkhomenko, A Al Mahmeed, W Fitzmaurice, D Chen, KN Zhao, YS Zhang, HQ Chen, JY Cao, SP Wang, DW Yang, YJ Li, WH Li, H Yin, YH Tao, GZ Yang, P Chen, YM He, SH Wang, Y Fu, GS Li, X Wu, TG Cheng, XS Yan, XW Zhao, RP Chen, MS Xiong, LG Chen, P Jiao, Y Guo, Y Xue, L Yang, ZM Jadhavm, P Sarma, R Kulkarni, G Chandwani, P Pothiwala, RA Purayil, MP Chawla, K Kothiwale, VA Raghuraman, B Vijan, VM Sawhney, J Bantwal, G Khan, A Meena, R Chopada, M Abraham, S Bisne, V Vijayaraghavan, G Roy, D Durgaprasad, R Shankar, AGR Kumar, S Jain, D Bhargava, K Kumar, V Nagamalesh, UM Rajput, RK Kanamori, S Yamamoto, K Kumagai, K Katsuda, Y Yoshida, K Toyota, F Mizuno, Y Misumi, I Noguchi, H Ando, S Suetsugu, T Minamoto, M Oda, H Adachi, S Chiba, K Norita, H Tsuruta, M Koyanagi, T Ando, H Higashi, T Okada, M Azakami, S Komaki, S Kumeda, K Murayama, T Matsumura, J Oba, Y Sonoda, R Goto, K Minoda, K Haraguchi, Y Suefuji, H Miyagi, H Kato, H Nakamura, T Nandate, H Zaitsu, R Fujiura, Y Yoshimura, A Numata, H Ogawa, J Kamogawa, Y Murakami, K Wakasa, Y Yamasawa, M Maekawa, H Abe, S Kihara, H Tsunoda, S Saito, K Tachibana, H Oba, I Kuwahata, T Higa, S Gushiken, M Eto, T Chibana, H Fujisawa, K Shiga, Y Sumi, H Nagatomo, T Atsuchi, Y Nagoshi, T Sanno, K Hoshino, F Yokota, N Kameko, M Tabuchi, T Ishizawa, M Ikeda, D Seto, T Iwao, T Ishioka, N Oshiro, K Tsuchida, K Hatori, Y Takeuchi, M Takezawa, H Nagano, S Iwaki, M Nakamura, Y Miyamoto, N Taguchi, T Ashida, K Yoshizawa, N Agata, J Matsukawa, S Arasaki, O Fukuoka, S Murakami, H Mishima, K Hata, Y Sakuma, I Obunai, K Takamura, I Akutsu, M Unoki, T Go, Y Ikemura, M Morii, S Marusaki, S Doi, H Tanaka, M Kusu-moto, T Kakinoki, S Ogurusu, C Murata, K Shimoyama, M Nakatsuka, M Kitami, Y Oyama, R Ageta, M Mita, T Nagao, K Mito, T Minami, J Abe, M Fujii, M Okawa, M Fujito, T Taniguchi, T Ko, T Kubo, H Imamaki, M Akiyama, M Ueda, T Odakura, H Inagaki, M Katsube, Y Nakata, A Tomimoto, S Shibuya, M Nakano, M Ito, K Matsuta, M Ishiguro, M Minagawa, T Wada, M Mukawa, H Mizuguchi, M Okuda, F Kimura, T Taga, K Techigawara, M Igarashi, M Watanabe, H Seo, T Hiramitsu, S Hosokawa, H Hoshiai, M Hibino, M Miyagawa, K Horie, H Sugishita, N Soma, A Neya, K Yoshida, T Akahane, K Takanaka, C Matsui, S Kanda, H Kaneko, M Nagasaka, S Taguchi, A Toru, S Miyashita, A Sasaguri, H Nariyama, J Hatsuno, T Iwase, T Sato, K Kawai, K Kotani, T Tsuji, T Sakai, H Nishino, K Ikeda, K Maeda, K Shinozuka, T Inoue, T Kawakami, K Kitazumi, H Takagi, T Hamaoka, M Kojima, J Sasaki, A Tsuchiya, Y Bet-suyaku, T Higuchi, K Honda, M Hasegawa, K Baba, T Mineoi, K Koeda, T Hirasawa, K Kumazaki, T Nakagomi, A Otaki, E Shindo, T Hirayama, H Sugimoto, C Yamagishi, T Mizuguchi, I Sezaki, K Niwa, I Takenaka, K Iiji, O Taya, K Kitazawa, H Ueda, S Kakuda, H Ono, T Oriso, S Kamata, J Nanke, T Maeda, I Matsuura, Y Teragawa, H Maruyama, Y Takei, K Hone, H Kito, TT Asano, H Matsushita, K Nakamura, M Washizuka, T Sawano, M Arima, S Arai, H Shinohara, H Takai, H Furukawa, N Ota, A Aoki, K Yamamoto, T Kasai, T Suzuki, S Shibata, N Watanabe, M Nishihata, Y Arino, T Okuyama, M Wakiyama, T Kato, T Sasagawa, Y Tana, T Hayashi, Y Hirota, S Abe, Y Saito, Y Uchiyama, H Takeda, H Ono, H Tohyo, S Hanazono, N Miyajima, S Shimono, H Aoyama, T Shozawa, Y Niijima, Y Murai, O Inaba, H Nomura, K Nozoe, M Suzuki, K Furukawa, T Shiraiwa, T Ito, N Nagai, S Nakahara, S Shimoyama, Y Ohara, N Kozuka, T Okita, H Endo, M Goto, T Hirose, M Nagata, E Nakanishi, N Mori, T Seki, S Okamoto, K Moriai, O Emura, Y Fukuda, T Date, H Kawakami, S Ueyama, Y Fudo, T Imaizumi, M Ogawa, T Take, S Ikeda, H Nishioka, H Sakamoto, N Ikeoka, K Wakaki, N Doiuchi, J Kira, T Tada, M Tsuzaki, K Miura, N Fujisawa, Y Furumoto, W Fujisawa, A Nakamura, R Komatsu, H Fujiki, R Kawano, S Nishizawa, K Kato, Y Azuma, J Yasui, K Amano, T Sekine, Y Honzawa, T Koshibu, Y Sakamoto, Y Seta, Y Miyaguchi, S Morishita, K Samejima, Y Sasaki, T Iseki, F Kobayashi, T Kano, H Kim, J Yamaguchi, H Takagi, Y Pearce, YO Suzuki, Y Fukui, T Nakayama, T Kanai, H Kawano, Y Ino, T Miyoshi, H Miyamoto, Y Shigekiyo, M Ono, S Okamoto, Y Ubukata, S Kodera, K Oriuchi, T Matsumoto, N Inagaki, K Iseki, A Goda, T Katsuki, T Sato, A Mori, E Tsubokura, T Shudo, H Fujimoto, S Katsuya, T Furukawa, Y Narumi, J Owari, M Inakura, T Anno, T Shirakawa, K Ching, CK Foo, D Wong, K Yuyang, T Park, HN Kim, WS Lee, H Jang, SW Kim, DH Ryu, D Shim, J Kim, DK Choi, DJ Oh, YS Cho, MC Kim, HL Jeon, HK Shin, DG Park, SW Park, HK Han, SJ Sung, JH Park, HW Nam, GB On, YK Lim, HE Kwak, J Cha, TJ Hong, TJ Park, SH Yoon, JH Kim, NH Kim, KS Jung, BC Hwang, GS Kim, CJ Rungaramsin, S Katekangplu, P Khunrong, P Bunyapipat, T Wongcharoen, W Kaewsuwanna, P Siriwattana, K Tiyanon, W Pattanaprichakul, S Likittanasombat, K Cholsaringkarl, D Boonyapisit, W Cheewatanakornkul, S Silaruks, S Hutayanon, P Chawanadelert, S Chattranukulchai, P Chatlaong, B Santanakorn, Y Kanokphatcharakun, K Mongkolwongroj, P Jai-Aue, S Komson, O Altun, A Aydinlar, A Topsakal, R Ongen, Z Acikel, S Sahin, DY Yilmaz, O Yilmaz, MB Pekdemir, H Demir, M Sucu, M Sahiner, L Ersanli, M Okuyan, E Aras, D Rolandi, F Ingaramo, AC Sambadaro, GA Caputi, VF Luciardi, H Berman, SG Dragotto, P Kleiban, AJ Centurion, N Guerrero, RAA Di Paola, LA Dran, RD Egido, J Fosco, MJ Sinisi, VA Cartasegna, LR Vilamajo, OG Ramos, JL Sassone, S Zapata, G Conde, D Giacomi, G Fernandez, AA Berli, MA Ferroni, F Sobral, DC Jaber, J Armaganijan, LV Costantini, CRF Steffens, A de Souzaem, WKSB Neto, JDD Ribeiro, JM Teixeira, MS Rossi, P Pires, L Moreira, D Jorge, JCM Lorga, AM Bodanese, L Montera, MW Del Carlo, CH Saad, JA Costa, FAA Lopes, R de Aranjo, GR Manenti, ER Saraiva, JFK Braga, JCF Negri, A Moncada, C Precoma, D Roquette, F Reis, G Ramos, RA Figueiredo, EL Botelho, RV Tavares, CMF Finimundi, HC Kochi, A Franca, CCB Alban, F Rosito, GBA Moraes, JBDX Tumelero, RT Maia, L de Almeida, RS Borges, NCC Ferreira, LGG Fernandez, BAJS Montecinos, H Lanas, F Gomez, ML Astudillo, C Conejeros, C Cuevas, PM Forero, A Gutierrez, CB Aguilar, J Cardenas, SP Eggers, G Houzvic, C Rey, C Arriagada, G Vilches, GC Diaz, JJI Cantu, RL Zavala, MGR Jardines, RC Zavaleta, NE Rosas, EL Esperon, GAL Pozas, G Munoz, EC Her-nandez, NM Rendon, AL Hernandez, NG Ibarra, MD Carrillo, LRV Villezca, DL Herrera, CH Prieto, JJL Rodriguez, RG Espinosa, EV Martinez, DF Barcena, JV Fierro, OF Briones, IR Pons, JLL Lopez, HA Ruiz, RO Brito, CGC Valenzuela, EJJRC Sanchez, RR Ruiz, AEB Ruiz, OML Nava, RA Cerda, JDM Campos, PF Gonzalez, MB Lenz, K Hagn, C Foechterle, J Drexel, H Huber, K Podczeck-Schweighofer, A Winkler, M Schneeweiss, B Gegenhuber, A Lang, W Eichinger-Hasenauer, S Kaserer, P Sykora, J Rasch, H Strohmer, B Capiau, L Vervoort, G Wollaert, B Hollanders, G Vercammen, J Faes, D Balthazar, Y Delforge, M Xhaet, O Striekwold, H Thoeng, J Hermans, K Mairesse, G Anne, W Blankoff, I Beutels, M Verstraete, S Vandergoten, P Purnode, P Godart, P Boussy, T Desfontaines, P Heyse, A Voet, J De Wolf, A Zidkova, E Spacek, R Machova, V Ludka, O Olsr, J Kotik, L Racz, B Ferkl, R Hubac, J Kotik, I Monhart, Z Burianova, H Jerabek, O Pisova, J Petrova, I Dedek, V Honkova, M Podrazil, P Reichert, P Spinar, J Novak, M Durdil, V Plocova, K Lastuvka, J Nielsen, J Husted, S Dominguez, H Hintze, U Rasmussen, S Sygehus, N Bremmelgaard, A Markenvard, J Borger, J Solgaard, J Eriksen, E Lokkegaard, T Bruun, M Mertz, J Schou, M Olsen, M Viitanen, C Paganelli, F Ohayon, J Casassus, F Galinier, M Gottwalles, Y Loiselet, P Muller, JJ Koujan, MB Marquand, A Destrac, S Piot, O Delarche, N Cebron, JP Guenoun, M Guedj-Meynier, D Lokesh, AG Zuber, M Amarenco, P Ellie, E Kadouch, J Fournier, PY Huberman, JP Lemaire, N Rodier, G Vandamme, X Sibon, I Neau, JP Mahagne, MH Mielot, A Bonnefoy, M Churet, JB Navarre, V Sellem, F Monniot, G Boyes, JP Doucet, B Martelet, M Obadia, D Crousillat, B Mouallem, J Bearez, E Brugnaux, JP Fedorowsky, A Nazeyrollas, P Berneau, JB Chemin, F Schellong, S Koeniger, G Kopf, A Gerbaulet, U Kellner, BT Schaefer, T Purr, J Eissfeller, E Zauzig, HD Riegel, P Axthelm, C Heinz, GU Menke, H Pustelnik, A Zutz, S Eder, W Rehling, G Glatzel, D Ludwig, N Sandow, P Wiswedel, H Wildenauer, C Schoen, S Schwarz, T Babyesiza, A Kropp, M Zimny, HH Kahl, F Caspar, A Omankowsky, S Laessig, T Hartmann, HJ Lehmann, G Bindig, HW Hergdt, G Reimer, D Hauk, J Michel, H Dres, P Erdle, W Dorsch, W Dshabrailov, J Rapp, KA Vormann, R Mueller, T Mayer, P Horstmeier, U Eissing, V Hey, H Leuchtgens, H Lilienweiss, V Mueller, H Schubert, C Lauer, H Buchner, T Brauer, G Kamin, S Mueller, K Baumbach, S Abdel-Qader, M Ebert, HH Schwencke, C Bernhardt, P Karolyi, L Sievers, B Haverkamp, W Roehnisch, JU Vertes, A Szantai, G Matoltsy, A Kanakaridisz, N Boda, Z Kis, E Gaszner, B Juhasz, F Juhasz, G Kancz, S Laszlo, Z May, Z Merkely, B Noon, E Habon, T Polgar, P Szalai, G Vangel, S Nagy, A Engelthaler, G Ferenczi, J Egyutt, M Martini, G Cristina, LM Tirafern, E Santoro, R Testa, S Di Minno, G Moia, M Caimi, TM Tessitori, M Cappelli, R Poli, D Quintavalla, R Cosmi, F Fanelli, R Oriana, V Reggio, R Anti, RS Pancaldi, L De Cristofaro, R Guazzaloca, G De Blasio, A Uriate, JS Lillo, F Pogliani, EM Bilo, G Accogli, M Mariani, A Feola, M Raisaro, A Fattore, L Mauric, A Germini, F Tedeschi, L Settimi, M Nicoli, S Ricciarini, P Argena, A Ronchini, P Bulla, C Tradati, F Volpe, M Avino, MD Bongiorni, MG Seven, S Capucci, A Lodigiani, C Salomone, E Serviddio, G Tondo, C Golino, P Mazzone, C Iacopino, S Ruiter, JH Lucassen, A Adriaansen, H Bongaerts, M Pieterse, M van Guldener, C Herrman, J Nierop, SHKPR Hoogslag, P Hermans, W Groenemeijer, BE Terpstra, W Buiks, C Boersma, LVA Berge, E Sirnes, PA Gjertsen, E Hole, T Erga, K Hallaraker, A Skjelvan, G Ostrem, A Ghezai, B Svilaas, A Christersson, P Oien, T Henrichsen, SH Otterstad, JE Berg-Johansen, J Gieroba, A Biedrzycka, M Ogorek, M Wozakowska-Kaplon, B Loboz-Grudzien, K Jaroslaw Supinski, W Kuzniar, J Zaluska, R Hiczkiewicz, J Swiatkowska-Byczynska, L Kucharski, L Gruchala, M Minc, P Olszewski, M Kania, G Krzciuk, M Lajkowski, Z Ostrowska-Pomian, B Lewczuk, J Zinka, E Karczmarczyk, A Chmielnicka-Pruszczynska, M Wozniak-Skowerska, I Opolski, G Bronisz, M Glanowska, G Ruszkowski, P Skonieczny, G Sciborski, R Okopien, B Kukla, P Galbas, K Cymerman, K Jurowiecki, J Miekus, P Myszka, W Mazur, S Lysek, R Baszak, J Rusicka-Piekarz, T Raczak, G Domanska, E Nessler, J Lesnik, J Eltishcheva, V Libis, R Kamalov, G Belenky, D Egorova, L Khokhlov, A Yakupov, E Zateyshchikov, D Barbarash, O Miller, O Mazur, E Zrazhevskiy, K Novikova, T Moiseeva, Y Polkanova, E Sobolev, K Rossovskaya, M Shapovalova, Y Kolesnikova, A Nikolaev, K Zemlianskaia, O Zateyshchikova, A Kostenko, V Popov, S Poltayskaya, M Edin, A Aleksandrova, E Drapkina, O Vishnevsky, A Nagibovich, O Chizhov, P Rachkova, S Sergeev, M Kurylo, B Ushakov, A Garcia, PA Fernandez, MFL Sanchez, LT Iparraguirre, ST Monserrat, PT Contreras, EM Rafecas, JI Carrasco, JM Pavia, PG Pajuelo, CG Diaz, LMR Alonso, LFI Ruiz, AG Klein, JM Juanatey, JRG Collado, IM Piquero, HP Cuixart, CB Escobar, EF Llibre, JBI Vicente, CC Gutierrez, MV Gonzalo, FE Fernandez, CAA Navarro, EM Alia, JJM Oliva, MAM Sanmartin, JI Gonzalez, MJ Alvarez, MDR Melenchon, JH Vera, TR Navarro, MJ Caamano, MV Tones, MFA Gomez, GM Romo, AI Diaz, MAP Wirdby, A Linden, J Henriksson, K Elmersson, M Egilsson, A Borjesson, U Svard, G Liu, B Lindh, A Olsson, LB Gustaysson, M Andersson, L Benson, L Bothin, C Hajimirsadeghi, A Martinsson, B Ericsson, M Ohlsson, A Lindvall, H Svensson, P Thorne, K Handel, H Platonov, P Bernsten, F Timberg, I Crisby, M Karlsson, JE Andersson, A Malmqvist, L Engdahl, J Thulin, J Hot-Bjelak, A Jensen, S Stalby, P Debrunner, J Beer, JH Shah, D Rudyk, I Tseluyko, V Karpenko, O Zhurba, S Kraiz, I Parkhomenko, O Kupnovytska, I Seredyuk, N Mostovoy, Y Ushakov, O Koval, O Kovalskiy, I Svyshchenko, Y Sychov, O Stanislavchuk, M Yagensky, A Tykhonova, S Fushtey, I Murdoch, W Chauhan, N Goodwin, D Lumley, L Patel, R Saunders, P Wong, B Cameron, A Patel, N Jhittay, P Ross, A Kainth, MS Ladha, K Douglas, K Pickavance, G McDonnell, J Handscombe, L Gooding, T Wagner, H Bradshaw, C Bromham, C Jones, K Suryani, S Coates, R Sarai, B Willcock, W Sircar, S Cairns, J Gilliand, A Bilas, R Strieder, E Hutchinson, P Wakeman, A Stokes, M Kirby, G Vishwanathan, B Bird, N Evans, P Clark, M Bisatt, J Litchfield, J Fisher, E Fooks, T Kelsall, R Paul, N Alborough, E Aziz, M Ramesh, C Wilson, P Franklin, S Fairhead, S Thompson, J Chowan, H Taylor, G Tragen, D Parfitt, M Seamark, C Paul, C Richardson, M Jefferies, A Sharp, H Jones, H Giles, C Bramley, M Williams, P Aldegather, J Wetherell, S Lumb, W Scouller, F Macey, N Rogers, S Stipp, Y West, R Pinney, P Wadeson, P Matthews, J Pandya, P Gallagher, A Railton, T Davies, E McClure, J Jacobs, M Hutton, C Thompson, R Sinha, B Butter, K Barrow, S Little, H Russell, D Choudhary, U Haq, I Ainsworth, P Jones, C Weeks, P Eden, J Gibbons, L Glencross, J MacLeod, A Poland, K Mulolland, C Warke, A Conn, P Burns, D Smith, R Kamath, R Webster, J Hodgins, I Vercoe, S Roome, P Pinnock, H Patel, J Ali, A Hart, N Davies, R De-Sousa, N Neden, C Danielsen, M Sharma, P Galloway, S Hawkins, C Oliver, R Aylward, M Pattni, M Irvine, G Ahmad, S Rothwell, C Choudhary, F Khalaque, S Short, S Peters, S Coulson, W Roberts, N Butler, A Coates, S Ward, B Jackson, D Walton, S Shepherd, D Wong, T Boon, M Deacon, M Cornelius, D Davies, S Ben Frankel Hargreaves, N Choi, H Sumner, J Myhill, T Estifanos, S Geatch, D Wilkinson, J Veale, R Forshaw, K Hirst, R Zaman, K Liley, C Wastling, R McEleny, P Beattie, A Cooke, P Wong, M Pugsley, M Dooldeniya, C Rogers, G Bennett, J Jacobs, P Muvva, R Adam, M Fox, R Thomas, N Cartwright, S Reed, R Randfield, S ACourt, C Flynn, A Halpin, A Dobson, S Lomax, L Nadaph, M Goram, J Stoddart, H Simmons, P Shewring, J Bowen-Simpkins, E Rickenbach, M Munro, I Blenkhorn, A Singh, B Astridge, P van Gaal, W Abhayaratna, W Thomson, P Lehman, R Kilian, J Coulshed, D Catanchin, A Colquhoun, D Kiat, H Eccleston, D French, J Ayres, B Blombery, P Phan, T Rogers, J O'Donnell, D Cheol, S Carroll, P Starmer, G Arstall, M Binnekamp, M Lee, A Luton, R Gupta, M Pandey, AS Cheung, S Leader, R Beaudry, P Ayala-Paredes, F Berlingieri, J Heath, J Poirier, G du Preez, M Schweitzer, B Nadeau, R Dhillon, R Hruczkowski, T Lavoie, A Parkash, R Cha, J Coutu, B MacDonald, P Ramjattan, B Bonet, J Vizel, S Angaran, P Fikry, S Mowafy, A Katta, A Tawfik, M Nawar, M Sobhy, M Abou Seif, SK Khairy, T Abd El-Aziz, A Taha, N Reda, A Elbahry, A Setiha, M El Din, MG Elkhadem, M El-Etreby, A Kettles, D Bayat, J Siebert, H Horak, A Kelfkens, Y Garda, R Pillay, T Guerra, M van Zyl, L Theron, H Murray, A Louw, R Greyling, D Mntla, P Ismail, S Ahmed, F Engelbrecht, J Maharajh, S Oosthuysen, W Loghdey, R Ueckermann, V Al Naeemi, A Yousef, G Bazargani, N Alomairi, M Maruthanayagam, R Singh, R Naguib, A Ibrahim, M Agrawal, A Nathani, M Esheiba, EM Wassef, A Gupta, R Cox, M Beach, S Duffy, P Falkowski, S Ferrick, K Franco, M Kutayli, WM Quick, A Sharma, N Wilson, V Miller, S Alberts, M Blumberg, E Canosa, R Gutowski, T Ison, R Garcia, J Mullen, P Noveck, H Rama, P Reddy, R Williams, M Nishijima, D Ferdinand, K Hague, I Mendelson, R Pitta, S Theodoro, D Treasure, C Moustafa, M Cader, C Pharr, W Oropallo, A Platt, G Gujral, J Welker, J Koura, F |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Anticoagulation Antiplatelet therapy Bleeding Mortality Stroke |
| topic |
Anticoagulation Antiplatelet therapy Bleeding Mortality Stroke |
| description |
BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes. METHODS: Adults with newly diagnosed atrial fibrillation and >= 1 investigator-defined stroke risk factor were enrolled in GARFIELD-AF between March 2010 and September 2015. The association between prior acute coronary syndromes and long-term outcomes was determined using a Cox proportional hazards model, adjusting for baseline risk factors, oral anticoagulation (OAC) +/- antiplatelet (AP) therapy, and usual care. RESULTS: Of 39,679 patients, 10.5% had a history of acute coronary syndromes. At 2-year follow-up, patients with prior acute coronary syndromes had higher adjusted risks of stroke/systemic embolism (hazard ratio [HR] 1.39; 95% confidence interval [CI], 1.08-1.78), major bleeding (HR 1.30; 95% CI, 0.95 -1.79), all-cause mortality (HR 1.34; 95% CI, 1.21 -1.49), cardiovascular mortality (HR 1.85; 95% CI, 1.51-2.26), and new acute coronary syndromes (HR 3.42; 95% CI, 2.62-4.45). Comparing antithrombotic therapy in the acute coronary syndromes vs no acute coronary syndromes groups, most patients received OAC +/- AP: 60.8% vs 66.1%, but AP therapy was more likely in the acute coronary syndromes group (68.1% vs 32.9%), either alone (34.9% vs 20.8%) or with OAC (33.2% vs 12.1%). Overall, 17.8% in the acute coronary syndromes group received dual AP therapy with (5.3%) or without OAC (12.5%). Among patients with moderate/high risk for stroke/systemic embolism, fewer in the acute coronary syndromes group received OAC with or without AP therapy (Congestive heart failure, Hypertension, Age 75 years, Diabetes mellitus, prior Stroke, TIA, or thromboembolism, Vascular disease, Age 65-74 years, Sex category [CHA(2)DS(2)-VASc] 2: 52.1% vs 64.6%; CHA(2)DS(2)-VASc >= 3: 62.0% vs 70.7%), and the majority with a Hypertension (uncontrolled systolic blood pressure >160 mm Hg), Abnormal renal or liver function, previous Stroke, Bleeding history or predisposition, Labile international normalized ratios, Elderly, and concomitant Drugs or alcohol excess (HAS-BLED) score >= 3 were on AP therapy (83.8% vs 65.5%). CONCLUSIONS: In GARFIELD-AF, previous acute coronary syndromes are associated with worse 2-year outcomes and a greater likelihood of under-treatment with OAC, while two-thirds of patients receive AP therapy. Major bleeding was more common with previous acute coronary syndromes, even after adjusting for all risk factors. (C) 2019 Elsevier Inc. All rights reserved. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://i3pt.portalinvestigacion.com/publicaciones/2841 |
| url |
https://i3pt.portalinvestigacion.com/publicaciones/2841 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
ELSEVIER SCIENCE INC |
| publisher.none.fl_str_mv |
ELSEVIER SCIENCE INC |
| dc.source.none.fl_str_mv |
American Journal of Medicine ISSN: 00029343 ISSNe: 15557162 reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí instname:Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| instname_str |
Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| reponame_str |
r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| collection |
r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869418041328009216 |
| spelling |
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AFVerheugt, FWAAmbrosio, GAtar, DBassand, JPCamm, AJCostabel, JPFitzmaurice, DAIllingworth, LGoldhaber, SZGoto, SHaas, SJansky, PKayani, GStepinska, JTurpie, AGGvan Eickels, MKakkar, AKHacke, WMantovani, LGMisselwitz, FPieper, KSKayani, GRFox, KAAGersh, BJLuciardi, HLGibbs, HBrodmann, MCools, FBarrett, ACPConnolly, SJSpyropoulos, AEikelboom, JCorbalan, RHu, DYNielsen, JDRagy, HRaatikainen, PLe Heuzey, JYDarius, HKeltai, MKakkar, SSawhney, JPSAgnelli, GKoretsune, YDiaz, CJSTen Cate, HPanchenko, ELim, TWJacobson, BOh, SVinolas, XRosenqvist, MSteffel, JAngchaisuksiri, POto, AParkhomenko, AAl Mahmeed, WFitzmaurice, DChen, KNZhao, YSZhang, HQChen, JYCao, SPWang, DWYang, YJLi, WHLi, HYin, YHTao, GZYang, PChen, YMHe, SHWang, YFu, GSLi, XWu, TGCheng, XSYan, XWZhao, RPChen, MSXiong, LGChen, PJiao, YGuo, YXue, LYang, ZMJadhavm, PSarma, RKulkarni, GChandwani, PPothiwala, RAPurayil, 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MNakamura, YMiyamoto, NTaguchi, TAshida, KYoshizawa, NAgata, JMatsukawa, SArasaki, OFukuoka, SMurakami, HMishima, KHata, YSakuma, IObunai, KTakamura, IAkutsu, MUnoki, TGo, YIkemura, MMorii, SMarusaki, SDoi, HTanaka, MKusu-moto, TKakinoki, SOgurusu, CMurata, KShimoyama, MNakatsuka, MKitami, YNakamura, YOda, HOyama, RAgeta, MMita, TNagao, KMito, TMinami, JAbe, MFujii, MOkawa, MFujito, TTaniguchi, TKo, TKubo, HImamaki, MAkiyama, MUeda, TOdakura, HInagaki, MKatsube, YNakata, ATomimoto, SShibuya, MNakano, MIto, KMatsuta, MIshiguro, MMinagawa, TWada, MMukawa, HMizuguchi, MOkuda, FKimura, TTaga, KTechigawara, MIgarashi, MWatanabe, HSeo, THiramitsu, SHosokawa, HHoshiai, MHibino, MMiyagawa, KHorie, HSugishita, NShiga, YSoma, ANeya, KYoshida, TAkahane, KAdachi, STakanaka, CMatsui, SKanda, HKaneko, MNagasaka, STaguchi, AToru, SSaito, KMiyashita, ASasaguri, HNariyama, JHatsuno, TIwase, TSato, KKawai, KKotani, TTsuji, TSakai, HNishino, KIkeda, KMaeda, KShinozuka, TInoue, TKawakami, KKitazumi, 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ESantoro, RTesta, SDi Minno, GMoia, MCaimi, TMTessitori, MCappelli, RPoli, DQuintavalla, RCosmi, FFanelli, ROriana, VReggio, RAnti, RSPancaldi, LDe Cristofaro, RGuazzaloca, GDe Blasio, AUriate, JSLillo, FPogliani, EMBilo, GAccogli, MMariani, AFeola, MRaisaro, AFattore, LMauric, AGermini, FTedeschi, LSettimi, MNicoli, SRicciarini, PArgena, ARonchini, PBulla, CTradati, FVolpe, MAvino, MDBongiorni, MGSeven, SCapucci, ALodigiani, CSalomone, EServiddio, GTondo, CGolino, PMazzone, CIacopino, SRuiter, JHLucassen, AAdriaansen, HBongaerts, MPieterse, Mvan Guldener, CHerrman, JNierop, SHKPRHoogslag, PHermans, WGroenemeijer, BETerpstra, WBuiks, CBoersma, LVABerge, ESirnes, PAGjertsen, EHole, TErga, KHallaraker, ASkjelvan, GOstrem, AGhezai, BSvilaas, AChristersson, POien, THenrichsen, SHOtterstad, JEBerg-Johansen, JGieroba, ABiedrzycka, MOgorek, MWozakowska-Kaplon, BLoboz-Grudzien, KJaroslawSupinski, WKuzniar, JZaluska, RHiczkiewicz, JSwiatkowska-Byczynska, LKucharski, LGruchala, MMinc, POlszewski, MKania, GKrzciuk, MLajkowski, ZOstrowska-Pomian, BLewczuk, JZinka, EKarczmarczyk, AChmielnicka-Pruszczynska, MWozniak-Skowerska, IOpolski, GBronisz, MOgorek, MGlanowska, GRuszkowski, PSkonieczny, GSciborski, ROkopien, BKukla, PGalbas, KCymerman, KJurowiecki, JMiekus, PMyszka, WMazur, SLysek, RBaszak, JRusicka-Piekarz, TRaczak, GDomanska, ENessler, JLesnik, JEltishcheva, VLibis, RKamalov, GBelenky, DEgorova, LKhokhlov, AYakupov, EZateyshchikov, DBarbarash, OMiller, OMazur, EZrazhevskiy, KNovikova, TMoiseeva, YPolkanova, ESobolev, KRossovskaya, MShapovalova, YKolesnikova, ANikolaev, KZemlianskaia, OZateyshchikova, AKostenko, VPopov, SPoltayskaya, MEdin, AAleksandrova, EDrapkina, OVishnevsky, ANagibovich, OChizhov, PRachkova, SSergeev, MKurylo, BUshakov, AGarcia, PAFernandez, MFLSanchez, LTIparraguirre, STMonserrat, PTContreras, EMRafecas, JICarrasco, JMPavia, PGPajuelo, CGDiaz, LMRAlonso, LFIRuiz, AGKlein, JMJuanatey, JRGCollado, IMPiquero, HPCuixart, CBEscobar, EFLlibre, JBIVicente, CCGutierrez, MVGonzalo, FEFernandez, CAANavarro, EMAlia, JJMGonzalez, MBOliva, MAMSanmartin, JIGonzalez, MJAlvarez, MDRMelenchon, JHVera, TRNavarro, MJCaamano, MVTones, MFAGomez, GMRomo, AIDiaz, MAPWirdby, ALinden, JHenriksson, KElmersson, MEgilsson, ABorjesson, USvard, GLiu, BLindh, AOlsson, LBGustaysson, MAndersson, LBenson, LBothin, CHajimirsadeghi, AMartinsson, BEricsson, MOhlsson, ALindvall, HSvensson, PThorne, KHandel, HPlatonov, PBernsten, FTimberg, ICrisby, MKarlsson, JEAndersson, AMalmqvist, LEngdahl, JThulin, JHot-Bjelak, AJensen, SStalby, PDebrunner, JBeer, JHShah, DRudyk, ITseluyko, VKarpenko, OZhurba, SKraiz, IParkhomenko, OKupnovytska, ISeredyuk, NMostovoy, YUshakov, OKoval, OKovalskiy, ISvyshchenko, YSychov, OStanislavchuk, MYagensky, ATykhonova, SFushtey, IMurdoch, WChauhan, NGoodwin, DLumley, LPatel, RSaunders, PWong, BCameron, APatel, NJhittay, PRoss, AKainth, MSLadha, KDouglas, KPickavance, GMcDonnell, JHandscombe, LGooding, TWagner, HBradshaw, CBromham, CJones, KSuryani, SCoates, RSarai, BWillcock, WSircar, SCairns, JGilliand, ABilas, RStrieder, EHutchinson, PWakeman, AStokes, MKirby, GVishwanathan, BBird, NEvans, PClark, MBisatt, JLitchfield, JFisher, EFooks, TKelsall, RPaul, NAlborough, EAziz, MRamesh, CWilson, PFranklin, SFairhead, SThompson, JChowan, HTaylor, GTragen, DParfitt, MSeamark, CPaul, CRichardson, MJefferies, ASharp, HJones, HGiles, CBramley, MWilliams, PAldegather, JWetherell, SLumb, WEvans, PScouller, FMacey, NRogers, SStipp, YWest, RPinney, PWadeson, PMatthews, JPandya, PGallagher, ARailton, TDavies, EMcClure, JJacobs, MHutton, CThompson, RSinha, BButter, KBarrow, SLittle, HRussell, DChoudhary, UHaq, IAinsworth, PJones, CWeeks, PEden, JGibbons, LGlencross, JMacLeod, APoland, KMulolland, CWarke, AConn, PBurns, DSmith, RKamath, RWebster, JHodgins, IVercoe, SRoome, PPinnock, HPatel, JAli, AHart, NDavies, RDe-Sousa, NNeden, CDanielsen, MSharma, PGalloway, SHawkins, COliver, RAylward, MPattni, MIrvine, GAhmad, SRothwell, CChoudhary, FKhalaque, SShort, SPeters, SCoulson, WRoberts, NButler, ACoates, SWard, BJackson, DWalton, SShepherd, DWong, TBoon, MDeacon, MCornelius, DDavies, SBen FrankelHargreaves, NChoi, HSumner, JMyhill, TEstifanos, SGeatch, DWilkinson, JVeale, RForshaw, KHirst, RZaman, KLiley, CWastling, RMcEleny, PBeattie, ACooke, PWong, MPugsley, MDooldeniya, CRogers, GBennett, JJacobs, PMuvva, RAdam, MFox, RThomas, NCartwright, SReed, RRandfield, SACourt, CFlynn, AHalpin, ADobson, SLomax, LNadaph, MGoram, JStoddart, HSimmons, PShewring, JBowen-Simpkins, ERickenbach, MMunro, IBlenkhorn, ASingh, BAstridge, Pvan Gaal, WAbhayaratna, WThomson, PLehman, RKilian, JCoulshed, DCatanchin, AColquhoun, DKiat, HEccleston, DFrench, JAyres, BBlombery, PPhan, TRogers, JO'Donnell, DCheol, SCarroll, PStarmer, GArstall, MBinnekamp, MLee, ALuton, RGupta, MPandey, ASCheung, SLeader, RBeaudry, PAyala-Paredes, FBerlingieri, JHeath, JPoirier, Gdu Preez, MSchweitzer, BNadeau, RDhillon, RHruczkowski, TLavoie, AParkash, RCha, JCoutu, BMacDonald, PRamjattan, BBonet, JVizel, SAngaran, PFikry, SMowafy, AKatta, ATawfik, MNawar, MSobhy, MAbou Seif, SKKhairy, TAbd El-Aziz, ATaha, NReda, AElbahry, ASetiha, MEl Din, MGElkhadem, MEl-Etreby, AKettles, DBayat, JSiebert, HHorak, AKelfkens, YGarda, RPillay, TGuerra, Mvan Zyl, LTheron, HMurray, ALouw, RGreyling, DMntla, PIsmail, SAhmed, FEngelbrecht, JMaharajh, SOosthuysen, WLoghdey, RUeckermann, VAl Naeemi, AYousef, GBazargani, NAlomairi, MMaruthanayagam, RSingh, RNaguib, AIbrahim, MAgrawal, ANathani, MEsheiba, EMWassef, AGupta, RCox, MBeach, SDuffy, PFalkowski, SFerrick, KFranco, MKutayli, WMQuick, ASharma, NWilson, VMiller, SAlberts, MBlumberg, ECanosa, RGutowski, TIson, RGarcia, JMullen, PNoveck, HRama, PReddy, RWilliams, MNishijima, DFerdinand, KHague, IMendelson, RPitta, STheodoro, DTreasure, CMoustafa, MCader, CPharr, WOropallo, APlatt, GGujral, JWelker, JKoura, FAnticoagulationAntiplatelet therapyBleedingMortalityStrokeBACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes. METHODS: Adults with newly diagnosed atrial fibrillation and >= 1 investigator-defined stroke risk factor were enrolled in GARFIELD-AF between March 2010 and September 2015. The association between prior acute coronary syndromes and long-term outcomes was determined using a Cox proportional hazards model, adjusting for baseline risk factors, oral anticoagulation (OAC) +/- antiplatelet (AP) therapy, and usual care. RESULTS: Of 39,679 patients, 10.5% had a history of acute coronary syndromes. At 2-year follow-up, patients with prior acute coronary syndromes had higher adjusted risks of stroke/systemic embolism (hazard ratio [HR] 1.39; 95% confidence interval [CI], 1.08-1.78), major bleeding (HR 1.30; 95% CI, 0.95 -1.79), all-cause mortality (HR 1.34; 95% CI, 1.21 -1.49), cardiovascular mortality (HR 1.85; 95% CI, 1.51-2.26), and new acute coronary syndromes (HR 3.42; 95% CI, 2.62-4.45). Comparing antithrombotic therapy in the acute coronary syndromes vs no acute coronary syndromes groups, most patients received OAC +/- AP: 60.8% vs 66.1%, but AP therapy was more likely in the acute coronary syndromes group (68.1% vs 32.9%), either alone (34.9% vs 20.8%) or with OAC (33.2% vs 12.1%). Overall, 17.8% in the acute coronary syndromes group received dual AP therapy with (5.3%) or without OAC (12.5%). Among patients with moderate/high risk for stroke/systemic embolism, fewer in the acute coronary syndromes group received OAC with or without AP therapy (Congestive heart failure, Hypertension, Age 75 years, Diabetes mellitus, prior Stroke, TIA, or thromboembolism, Vascular disease, Age 65-74 years, Sex category [CHA(2)DS(2)-VASc] 2: 52.1% vs 64.6%; CHA(2)DS(2)-VASc >= 3: 62.0% vs 70.7%), and the majority with a Hypertension (uncontrolled systolic blood pressure >160 mm Hg), Abnormal renal or liver function, previous Stroke, Bleeding history or predisposition, Labile international normalized ratios, Elderly, and concomitant Drugs or alcohol excess (HAS-BLED) score >= 3 were on AP therapy (83.8% vs 65.5%). CONCLUSIONS: In GARFIELD-AF, previous acute coronary syndromes are associated with worse 2-year outcomes and a greater likelihood of under-treatment with OAC, while two-thirds of patients receive AP therapy. Major bleeding was more common with previous acute coronary syndromes, even after adjusting for all risk factors. (C) 2019 Elsevier Inc. All rights reserved.ELSEVIER SCIENCE INC2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/2841American Journal of MedicineISSN: 00029343ISSNe: 15557162reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p28412026-06-21T15:30:37Z |
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