Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)

Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides from seven years old children of a birth cohort study (n=199; PHIME cohort of Trieste, Italy) have been measured. Six OP and two PYR metabolites have been investigated, 2-diethylamino-6-methylpyrimidin-4-ol (DEAMPY, pirimiph...

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Autores: Bravo, Natalia, Grimalt, Joan O., Bocca, Beatrice, Pino, Anna, Bin, Maura, Brumatti, Liza Vecchi, Rosolen, Valentina, Barbone, Fabio, Ronfani, Luca, Alimonti, Alessandro, Calamandrei, Gemma
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/201978
Acceso en línea:http://hdl.handle.net/10261/201978
Access Level:acceso abierto
Palabra clave:Children
Estimated daily intakes
Human biomonitoring
Organophosphate pesticides
Pyrethroids
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/4
Ensure healthy lives and promote well-being for all at all ages
Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all
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spelling Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)Bravo, NataliaGrimalt, Joan O.Bocca, BeatricePino, AnnaBin, MauraBrumatti, Liza VecchiRosolen, ValentinaBarbone, FabioRonfani, LucaAlimonti, AlessandroCalamandrei, GemmaChildrenEstimated daily intakesHuman biomonitoringOrganophosphate pesticidesPyrethroidshttp://metadata.un.org/sdg/3http://metadata.un.org/sdg/4Ensure healthy lives and promote well-being for all at all agesEnsure inclusive and equitable quality education and promote lifelong learning opportunities for allUrinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides from seven years old children of a birth cohort study (n=199; PHIME cohort of Trieste, Italy) have been measured. Six OP and two PYR metabolites have been investigated, 2-diethylamino-6-methylpyrimidin-4-ol (DEAMPY, pirimiphos metabolite) was the one found at higher concentrations, median 3.4 ng/mL specific gravity adjusted (SG adjusted), followed by 4-nitrophenol (PNP, median 1.4 ng/mL SG adjusted) and 3,5,6-trichloro-2-pyridinol (TCPY, median 0.36 ng/mL SG adjusted), parathion and chlorpyriphos metabolites, respectively. TCPY concentrations were low in comparison to other distributions of OP metabolites in children from other studies. Accordingly, the PHIME cohort showed a distinct OP metabolite distribution with high concentrations of pirimiphos and parathion. Another specific characteristic of this cohort was the high concentration of 3-phenoxybenzoic acid (3-BPA, median 0.36 ng/mL SG adjusted), a general metabolite of PYR pesticides. Evaluation of anthropometric and socio-demographic characteristics of children and families only showed a positive association between family educational level and urinary concentrations of DEAMPY metabolite (p<0.05), which could reflect distinct dietary habits depending on the educational level. Estimated daily intakes were evaluated, all studied metabolites were found within safe levels. © 2019 Elsevier Inc.Authors are grateful to the women who participated in our study as well as the people who helped in the recruitment in the different countries. This work was supported by the EU through its Sixth Framework Programme for RTD project PHIME (contract no FOOD-CT-2006- 016253), by GRANT LIFE 2012 ENV/GR/001040 "Crome Life - Cross Mediterranean Environment and Health Network”, by European Union projects HEALS (FP7-ENV-2013- 603946) and Neurosome (H2020-MSCA-ITN-2017 SEP-210411486), by RC 12/12 of Institute for Maternal and Child Health -IRCCS “Burlo Garofolo” – Trieste – Italy funded by the Italian Ministry of Health.Peer reviewedElsevierEuropean CommissionBravo, Natalia [0000-0002-1460-6500]Grimalt, Joan O. [0000-0002-7391-5768]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/201978reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/603946https://doi.org/10.1016/j.envres.2019.05.039Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2019782026-05-22T06:33:51Z
dc.title.none.fl_str_mv Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
title Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
spellingShingle Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
Bravo, Natalia
Children
Estimated daily intakes
Human biomonitoring
Organophosphate pesticides
Pyrethroids
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/4
Ensure healthy lives and promote well-being for all at all ages
Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all
title_short Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
title_full Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
title_fullStr Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
title_full_unstemmed Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
title_sort Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)
dc.creator.none.fl_str_mv Bravo, Natalia
Grimalt, Joan O.
Bocca, Beatrice
Pino, Anna
Bin, Maura
Brumatti, Liza Vecchi
Rosolen, Valentina
Barbone, Fabio
Ronfani, Luca
Alimonti, Alessandro
Calamandrei, Gemma
author Bravo, Natalia
author_facet Bravo, Natalia
Grimalt, Joan O.
Bocca, Beatrice
Pino, Anna
Bin, Maura
Brumatti, Liza Vecchi
Rosolen, Valentina
Barbone, Fabio
Ronfani, Luca
Alimonti, Alessandro
Calamandrei, Gemma
author_role author
author2 Grimalt, Joan O.
Bocca, Beatrice
Pino, Anna
Bin, Maura
Brumatti, Liza Vecchi
Rosolen, Valentina
Barbone, Fabio
Ronfani, Luca
Alimonti, Alessandro
Calamandrei, Gemma
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Bravo, Natalia [0000-0002-1460-6500]
Grimalt, Joan O. [0000-0002-7391-5768]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Children
Estimated daily intakes
Human biomonitoring
Organophosphate pesticides
Pyrethroids
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/4
Ensure healthy lives and promote well-being for all at all ages
Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all
topic Children
Estimated daily intakes
Human biomonitoring
Organophosphate pesticides
Pyrethroids
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/4
Ensure healthy lives and promote well-being for all at all ages
Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all
description Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides from seven years old children of a birth cohort study (n=199; PHIME cohort of Trieste, Italy) have been measured. Six OP and two PYR metabolites have been investigated, 2-diethylamino-6-methylpyrimidin-4-ol (DEAMPY, pirimiphos metabolite) was the one found at higher concentrations, median 3.4 ng/mL specific gravity adjusted (SG adjusted), followed by 4-nitrophenol (PNP, median 1.4 ng/mL SG adjusted) and 3,5,6-trichloro-2-pyridinol (TCPY, median 0.36 ng/mL SG adjusted), parathion and chlorpyriphos metabolites, respectively. TCPY concentrations were low in comparison to other distributions of OP metabolites in children from other studies. Accordingly, the PHIME cohort showed a distinct OP metabolite distribution with high concentrations of pirimiphos and parathion. Another specific characteristic of this cohort was the high concentration of 3-phenoxybenzoic acid (3-BPA, median 0.36 ng/mL SG adjusted), a general metabolite of PYR pesticides. Evaluation of anthropometric and socio-demographic characteristics of children and families only showed a positive association between family educational level and urinary concentrations of DEAMPY metabolite (p<0.05), which could reflect distinct dietary habits depending on the educational level. Estimated daily intakes were evaluated, all studied metabolites were found within safe levels. © 2019 Elsevier Inc.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/201978
url http://hdl.handle.net/10261/201978
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/603946
https://doi.org/10.1016/j.envres.2019.05.039
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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