Detector Characterization of a High-Resolution Ring for PET Imaging of Mice Heads with sub-200 ps TOF
[EN] Positron emission tomography (PET) stands out as a highly specific molecular imaging technique. However, its detection sensitivity remains a challenge. The implementation of time-of-flight (TOF) PET technology enhances sensitivity by precisely measuring the time lapse between the annihilation p...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/220073 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/220073 |
| Access Level: | acceso abierto |
| Palabra clave: | CTR, LYSO Pixelated detector Time-of-flight (TOF)-positron emission tomography (PET) TOFPET2 Transit time spread (TTS) Voronoi diagrams |
| Sumario: | [EN] Positron emission tomography (PET) stands out as a highly specific molecular imaging technique. However, its detection sensitivity remains a challenge. The implementation of time-of-flight (TOF) PET technology enhances sensitivity by precisely measuring the time lapse between the annihilation photons. Moreover, by characterizing scattered (Compton) events, the effective sensitivity of PET imaging might significantly be enhanced. In this work, we present the scatter subsystem of a 2 layers preclinical TOF-PET scanner for mice head imaging. The scatter subsystem is composed of eight identical modules based on analog silicon photomultipliers (SiPMs) coupled to crystal arrays of 24x24 LYSO pixels with 0.95 mm x0 .95 mm x 3 mm dimensions. The system has 29-mm bore and 50.8-mm axial length. An average CTR of 192 +/- 1 ps was obtained for the whole subsystem at the photopeak energy range after energy and timing corrections, and CTR values as good as 155 ps were found for some individual pixels. The transit time spread at the SiPM level was also studied and corrected, achieving a mean value of 41 ps of maximum time difference at the sensor corners with respect to the center. Voronoi diagrams were implemented to correct for position decoding. |
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